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  • Journal article
    Pauliah SS, Shankaran S, Wade A, Cady EB, Thayyil Set al., 2013,

    Therapeutic hypothermia for neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis

    , PLoS ONE, Vol: 8, ISSN: 1932-6203

    Although selective or whole body cooling combined with optimal intensive care improves outcomes following neonatal encephalopathy in high-income countries, the safety and efficacy of cooling in low-and middle-income countries is not known.Objective:We performed a systematic review and meta-analysis of all published randomised or quasi-randomised controlled trials of cooling therapy for neonatal encephalopathy in low-and middle-income countries.Results:Seven trials, comprising a total of 567 infants were included in the meta-analysis. Most study infants had mild (15%) or moderate encephalopathy (48%) and did not receive invasive ventilation (88%). Cooling devices included water-circulating cooling caps, frozen gel packs, ice, water bottles, and phase-changing material. No statistically significant reduction in neonatal mortality was seen with cooling (risk ratio: 0.74, 95% confidence intervals: 0.44 to 1.25). Data on other neonatal morbidities and long-term neurological outcomes were insufficient.Conclusion:Cooling therapy was not associated with a statistically significant reduction in neonatal mortality in low-and middle-income countries although the confidence intervals were wide and not incompatible with results seen in high-income countries. The apparent lack of treatment effect may be due to the heterogeneity and poor quality of the included studies, inefficiency of the low technology cooling devices, lack of optimal neonatal intensive care, sedation and ventilatory support, overuse of oxygen, or may be due to the intrinsic difference in the population, for example higher rates of perinatal infection, obstructed labor, intrauterine growth retardation and maternal malnutrition. Evaluation of the safety and efficacy of cooling in adequately powered randomised controlled trials is required before cooling is offered in routine clinical practice in low-and middle-income countries.

  • Journal article
    Soe A, Apampa B, Fernando B, Maaskant JM, Neubert A, Thayyil S, Vermeulen H, Ghaleb MAet al., 2013,

    Interventions for reducing medication errors in children in hospital

    , Cochrane Database of Systematic Reviews, Vol: 2013

    © 2013 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the effectiveness of interventions to reduce medication errors (MEs) in hospitalised children.

  • Journal article
    Addison S, Sebire NJ, Taylor AM, Abrams D, Peebless D, Mein C, Munroe PB, Thayyil Set al., 2012,

    High quality genomic DNA extraction from postmortem fetal tissue

    , JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 25, Pages: 2467-2469, ISSN: 1476-7058
  • Journal article
    Arthurs O, Thayyil S, Wade A, Chong WKK, Sebire NJ, Taylor AMet al., 2012,

    MR determination of neonatal spinal canal depth

    , EUROPEAN JOURNAL OF RADIOLOGY, Vol: 81, Pages: E813-E816, ISSN: 0720-048X
  • Journal article
    Sebire NJ, Weber MA, Thayyil S, Mushtaq I, Taylor A, Chitty LSet al., 2012,

    Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination ("keyhole autopsy"): feasibility and initial experience

    , JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, Vol: 25, Pages: 513-518, ISSN: 1476-7058
  • Journal article
    Thayyil S, De Vita E, Sebire NJ, Bainbridge A, Thomas D, Gunny R, Chong K, Lythgoe MF, Golay X, Robertson NJ, Cady EB, Taylor AMet al., 2012,

    Post-mortem cerebral magnetic resonance imaging T-1 and T-2 in fetuses, newborns and infants

    , EUROPEAN JOURNAL OF RADIOLOGY, Vol: 81, Pages: E232-E238, ISSN: 0720-048X
  • Journal article
    Thayyil S, Sebire NJ, Chitty LS, Wade A, Olsen O, Gunny RS, Offiah A, Saunders DE, Owens CM, Chong WKK, Robertson NJ, Taylor AMet al., 2011,

    Post mortem magnetic resonance imaging in the fetus, infant and child: a comparative study with conventional autopsy (MaRIAS Protocol)

    , BMC Pediatrics, Vol: 11, ISSN: 1471-2431

    Background:Minimally invasive autopsy by post mortem magnetic resonance (MR) imaging has been suggested as an alternative for conventional autopsy in view of the declining consented autopsy rates. However, large prospective studies rigorously evaluating the accuracy of such an approach are lacking. We intend to compare the accuracy of a minimally invasive autopsy approach using post mortem MR imaging with that of conventional autopsy in fetuses, newborns and children for detection of the major pathological abnormalities and/or determination of the cause of death.Methods/Design:We recruited 400 consecutive fetuses, newborns and children referred for conventional autopsy to one of the two participating hospitals over a three-year period. We acquired whole body post mortem MR imaging using a 1.5 T MR scanner (Avanto, Siemens Medical Solutions, Enlargen, Germany) prior to autopsy. The total scan time varied between 90 to 120 minutes. Each MR image was reported by a team of four specialist radiologists (paediatric neuroradiology, paediatric cardiology, paediatric chest & abdominal imaging and musculoskeletal imaging), blinded to the autopsy data. Conventional autopsy was performed according to the guidelines set down by the Royal College of Pathologists (UK) by experienced paediatric or perinatal pathologists, blinded to the MR data. The MR and autopsy data were recorded using predefined categorical variables by an independent person.Discussion:Using conventional post mortem as the gold standard comparator, the MR images will be assessed for accuracy of the anatomical morphology, associated lesions, clinical usefulness of information and determination of the cause of death. The sensitivities, specificities and predictive values of post mortem MR alone and MR imaging along with other minimally invasive post mortem investigations will be presented for the final diagnosis, broad diagnostic categories and for specific diagnosis of each system.Clinical Trial Registration:

  • Journal article
    Thayyil S, Shankaran S, Cowan F, Ayer M, Price D, Bainbridge A, Cady E, Marlow N, Costello A, Robertson N, Guhan Bet al., 2011,

    BRAIN INJURY FOLLOWING WHOLE BODY COOLING AFTER NEONATAL ENCEPHALOPATHY IN A SOUTH INDIAN NEONATAL UNIT

    , PEDIATRIC RESEARCH, Vol: 70, Pages: 33-33, ISSN: 0031-3998
  • Conference paper
    Addison S, Sebire NJ, Judge-Kronis L, Taylor AM, Abrams D, Scott R, Robertson NJ, Peebles D, Mein C, Munroe PB, Thayyil Set al., 2011,

    GENOMIC DEOXYRIBONUCLEIC ACID EXTRACTION FROM POST MORTEM FETAL TISSUE

    , Publisher: NATURE PUBLISHING GROUP, Pages: 406-406, ISSN: 0031-3998
  • Conference paper
    Chandrasekaran M, Thayyil S, Bainbridge A, Kendall G, Gunny R, Cady E, Marlow N, Robertson NJet al., 2011,

    PROGNOSTIC ACCURACY OF THALAMIC PROTON MAGNETIC RESONANCE SPECTROSCOPY FOLLOWING THERAPEUTIC HYPOTHERMIA IN NEONATAL ENCEPHALOPATHY

    , Publisher: NATURE PUBLISHING GROUP, Pages: 161-161, ISSN: 0031-3998

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