@article{Montaldo:2016:10.1186/s12880-016-0137-9,
author = {Montaldo, P and Addison, S and Oliveira, V and Lally, PJ and Taylor, AM and Sebire, NJ and Thayyil, S and Arthurs, OJ},
doi = {10.1186/s12880-016-0137-9},
journal = {BMC MEDICAL IMAGING},
title = {Quantification of Maceration Changes using Post Mortem MRI in Fetuses},
url = {http://dx.doi.org/10.1186/s12880-016-0137-9},
volume = {16},
year = {2016}
}

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TY  - JOUR
AB  - BackgroundPost mortem imaging is playing an increasingly important role in perinatal autopsy, andcorrect interpretation of imaging changes is paramount. This is particularly importantfollowing intra-uterine fetal death, where there may be fetal maceration. The aim of thisstudy was to investigate whether any changes seen on a whole body fetal post mortemmagnetic resonance imaging (PMMR) correspond to maceration at conventionalautopsy.Methods: We performed pre-autopsy PMMR in 75 fetuses using a 1.5 Tesla SiemensAvanto MR scanner (Erlangen, Germany). PMMR images were reported blinded to theclinical history and autopsy data using a numerical severity scale (0 = no macerationchanges to 2 = severe maceration changes) for 6 different visceral organs (total 12).The degree of maceration at autopsy was categorized according to severity on anumerical scale (1 = no maceration to 4 = severe maceration). We also generatedquantitative maps to measure the liver and lung T2.Results: The mean PMMR maceration score correlated well with the autopsymaceration score (R2=0.93). A PMMR score of ≥ 4.5 had a sensitivity of 91%,specificity of 64%, for detecting moderate or severe maceration at autopsy. Liver andlung T2 were increased in fetuses with maceration scores of 3-4 in comparison tothose with 1-2 (liver p=0.03, lung p=0.02).Conclusions: There was a good correlation between PMMR maceration score and theextent of maceration seen at conventional autopsy. This score may be useful ininterpretation of fetal PMMR.
AU  - Montaldo,P
AU  - Addison,S
AU  - Oliveira,V
AU  - Lally,PJ
AU  - Taylor,AM
AU  - Sebire,NJ
AU  - Thayyil,S
AU  - Arthurs,OJ
DO  - 10.1186/s12880-016-0137-9
PY  - 2016///
SN  - 1471-2342
TI  - Quantification of Maceration Changes using Post Mortem MRI in Fetuses
T2  - BMC MEDICAL IMAGING
UR  - http://dx.doi.org/10.1186/s12880-016-0137-9
UR  - http://hdl.handle.net/10044/1/31285
VL  - 16
ER  - 

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