CPSE Webinar Series

At the CPSE Annual Industrial Consortium meeting in December 2016, there was a lot of enthusiasm for a webinar series that would be available to our consortium members, showcasing some of the work that goes on at CPSE from both University College London and Imperial College London. We are delighted to be hosting the webinar by Professor Mantalaris.

Bioprocess systems engineering: Transferring traditional process engineering principles to industrial biotechnology - the date of the webinar will be announced soon.

Professor Athanasios (Sakis) Mantalaris

Professor Athanasios (Sakis) Mantalaris is Professor of BioSystems Engineering in the Department of Chemical Engineering at Imperial College London and a member of the  Centre for Process Systems Engineering (CPSE). He received his PhD (2000) in Chemical Engineering from the University of  Rochester.  His expertise is in modelling of biological systems and bioprocesses with a focus on mammalian cell culture systems, stem cell bioprocessing, and tissue engineering. He has published over 160 original manuscripts, co-edited one book, and holds   several patents with several more pending. He has received several awards including the Junior Moulton Award for best paper by the Institute of Chemical Engineers (IChemE) in 2004. In 2012, he was elected Fellow of the American Institute for Medical & Biological Engineering and in 2013 he was awarded a European Research Council (ERC) Advanced Award. In 2015, he was awarded the Donald Medal by the Institution of Chemical Engineers (IChemE) for his contributions to  biochemical engineering.

Abstract: The complexity of the regulatory network and the interactions that occur in the intracellular environment of microorganisms highlight the importance in developing tractable mechanistic models of cellular functions and systematic approaches for modelling biological systems. To this end, the existing process systems engineering approaches can serve as a vehicle for understanding, integrating and designing biological systems and processes. Here, we review the application of a holistic approach for the development of mathematical models of biological systems, from the initial conception of the model to its final application in model-based control and optimisation. We also discuss the use of mechanistic models that account for gene regulation, in an attempt to advance the empirical expressions traditionally used to describe micro-organism growth kinetics, and we highlight current and future challenges in mathematical biology. The modelling research framework discussed herein could prove beneficial for the design of optimal bioprocesses, employing rational and feasible approaches towards the efficient production of chemicals and pharmaceuticals.

The date of the webinar will be announced soon. The talk is  for one-hour online session: 40 minutes' presentation + 20 minutes' Q&A. 

You can also watch previous webinars here.