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Pioneering research

In the last decade, a number of research groups in Europe and the Americas have conducted studies into the safety and effectiveness of psychedelics for conditions such as depression and post-traumatic stress disorder (PTSD), but the Imperial Centre for Psychedelic Research is the first to gain this level of stature within a major academic institution.

When delivered safely and professionally, psychedelic therapy holds a great deal of promise for treating some very serious mental health conditions.

Dr Robin Carhart-Harris

Head of the Centre for Psychedelic Research

Ours was the first Centre in the world to investigate the brain effects of LSD using modern brain imaging and the first to study psilocybin – the active compound in magic mushrooms – for treating severe depression. These studies have laid the groundwork for larger trials that are now taking place around the world. Other pioneering work from the group includes breakthrough neuroimaging research with psilocybin, MDMA and DMT (the psychoactive compounds found in ecstasy and ayahuasca respectively).

Earlier this year the group began a new trial directly comparing psilocybin therapy with a conventional antidepressant drug in patients with depression – a study for which they are still recruiting volunteers. Building on this, they also plan to begin another new trial next year to explore the safety and feasibility of psilocybin for treating patients with anorexia.

Dr Carhart-Harris adds: “It may take a few years for psychedelic therapy to be available for patients, but research so far has been very encouraging. Early stage clinical research has shown that when delivered safely and professionally, psychedelic therapy holds a great deal of promise for treating some very serious mental health conditions and may one day offer new hope to vulnerable people with limited treatment options.”


If you are a student interested in conducting research with our Centre, please see the page join our research team.

Research publications

Citation

BibTex format

@article{Cofré:2019:10.3390/e21090884,
author = {Cofré, R and Videla, L and Rosas, F},
doi = {10.3390/e21090884},
journal = {Entropy},
pages = {1--28},
title = {An introduction to the non-equilibrium steady states of maximum entropy spike trains},
url = {http://dx.doi.org/10.3390/e21090884},
volume = {21},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Although most biological processes are characterized by a strong temporal asymmetry, several popular mathematical models neglect this issue. Maximum entropy methods provide a principled way of addressing time irreversibility, which leverages powerful results and ideas from the literature of non-equilibrium statistical mechanics. This tutorial provides a comprehensive overview of these issues, with a focus in the case of spike train statistics. We provide a detailed account of the mathematical foundations and work out examples to illustrate the key concepts and results from non-equilibrium statistical mechanics.
AU - Cofré,R
AU - Videla,L
AU - Rosas,F
DO - 10.3390/e21090884
EP - 28
PY - 2019///
SN - 1099-4300
SP - 1
TI - An introduction to the non-equilibrium steady states of maximum entropy spike trains
T2 - Entropy
UR - http://dx.doi.org/10.3390/e21090884
UR - https://www.mdpi.com/1099-4300/21/9/884
UR - http://hdl.handle.net/10044/1/73582
VL - 21
ER -