Group II - Type II receptors

Human sequence alignment
Joint human/mouse sequence alignment
Introduction
Mammalian proteins containing CTLDs
Introduction  Domain organization  Sequence alignments  Human database  Mouse database  Joint human/mouse database

 

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CYTOPLASMIC TAIL and TRANSMEMBRANE REGION
 
LSECtin                          MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVLWAVILSILL
IgFcR                                    MEEGQYSEIEELPRRRCC--RRGTQIVLLGLVTAALWAGLLTLLLLWHW
DC-SIGN          MSDSKEPRLQQLGLLEEE--------QLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLL----VQVS
DC-SIGNR         MSDSKEPRVQQLGLLEEDPTTSGIRLFPRDFQFQQIHGHKSSTGCLGHGALVLQLLSFMLLAGVLVAILVQVS
ASGPR-H1    MTKEYQDLQHLDNEESDHHQLR------------------KGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGS
ASGPR-H2    MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGS
ASGPR-M     MTRTYENFQYLENKVKVQGFK-------------------NGPLPLQSLLQRLRSGPCHLLLSLGLGLLLLVIICVVGF
DCIR                      MTSEITYAEVRFKNEFKSSGINTASSAASKERTAPLKSNTGFPKLLCASLLIFFLLLAISFFIAFVIFF
Dectin-2                                            MMQEQQPQSTEKRGWLSLRLWSVAGISIALLSACFIVSCVV
Mincle                                          MNSSKSSETQCTERGCF-SSQMFLWTVAGIPILFLSACFITRCVVTF
BDCA-2                                             MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVV
CLEC-6                                              MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLGVCFIASCLV
SRCL                             MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGY
Langerin                MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQAVLYP
 
POTENTIAL INTERNALISATION SIGNAL     TRANSMEMBRANE DOMAIN

 

NECK REGION: COILED-COIL and COLLAGEN-LIKE DOMAINS
 
LSECtin   SKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQN
 
IgFcR     DTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQ                  
                      ISQELEELRAEQQRLKSQDLE
                      LSWNLNGLQADLSSFKSQELNERNE
                      ASDLLERLREEVTKLRMELQVSSG
 
DC-SIGN   KVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQE
                         IYQELTQLKAAVGELPEKSKLQE
                         IYQELTRLKAAVGELPEKSKLQE
                         IYQELTWLKAAVGELPEKSKMQE
                         IYQELTRLKAAVGELPEKSKQQE
                         IYQELTRLKAAVGELPEKSKQQE
                         IYQELTRLKAAVGELPEK
DC-SIGNR  KVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQE
                         IYQELTQLKAAVGELPEKSKLQE
                         IYQELTRLKAAVGELPEKSKLQE
                         IYQELTRLKAAVGELPEKSKLQE
                         IYQELTRLKAAVGELPEKSKLQE
                         IYQELTELKAAVGELPEKSKLQE
                         IYQELTQLKAAVGELPDQSKQQQ
                         IYQELTDLKTAFE
 
 
ASGPR-H1  QN-----SQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRS
ASGPR-H2  QSEGHRGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRF
ASGPR-M   QN-----SKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAVHSEMLLR------------------------VQQLVQDLKK
                       
DCIR      QKYSQLLEKKTTKELVHTT
Dectin-2  TYHFTYGETGKRLSELHSYHSS
Mincle    RIFQTCDEKKFQLPENFTE
BDCA-2    PHNFMYSKTVKRLSKLREYQQYHPS
CLEC-6    THHNFSRCKRGTGVHKLEHHAK
 
SRCL        KVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSE
              LSTFRSDILDLRQQLREITEKTSKNKDT
              LEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQNQMYSHNV
          VIMNLNNLNLTQVQQRNL
              ITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDT
              LEDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIK
              FNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLTKHTDD
              LTSLNNTLANIRLDSVSLRMQQDLMRSR
          LDTEVANLSVIMEEMKLVDSKHGQL
              IKNFTILQ
 
SRCL      GPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKP
                GPQGPSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAV
 
 
Langerin  RFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVRSQFLKLKTSV
                EKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLENMSKLLKRQNDIL
 
 
Kupffer*  ANAEIQGLKENLQNTNALNSQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVLKRDLKMVTAQTQKANGRLDQTDTQIQVFKSEMENVNT
                LNAQIQVLNGHMKNASREIQTLKQGMK-NASALTSQTQMLDSNLQKASAEIQRLRGDLENTKALTMEIQQEQSRLKTLHVVITSQEQLQRTQS
 
              HEPTAD REPEAT     COLLAGENOUS DOMAIN

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CTLD - N-TERMINAL
 
LSECtin                   NSCEPCPTSWLSFEGSCYFFSVPKTT--WAAAQDHCADASAHLVIVGGLDEQGFLTRNT-RGRGY-WLGLRAVRHLGKVQ
IgFcR                     FVCNTCPEKWINFQRKCYYFGKGTKQ--WVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTG--SWIGLRNLDLKG
DC-SIGN                   RLCHPCPWEWTFFQGNCYFMSNSQRN--WHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEG
DC-SIGNR                  RLCRHCPKDWTFFQGNCYFMSNSQRN--WHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEG
ASGPR-H1  LSCQMAALQGNG----SERTCCPVNWVEHERSCYWFSRSGKA--WADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVN--TWMGLHD--QNG
ASGPR-H2  VACQMELLHSNG----SQRTCCPVNWVEHQGSCYWFSHSGKA--WAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFN--TWIGLTD--SDG
ASGPR-M   LTCQVATLNNNGEEASTEGTCCPVNWVEHQDSCYWFSHSGMS--WAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAY--TWMGLSD--PEG
DCIR      LECVKKNM----PVEETAWSCCPKNWKSFSSNCYFISTESAS--WQDCEKDCARMEAHLLVINTQEEQDFIFQNLQEES-AYFVGLSDPEGQR
Dectin-2  LTCFSEGV----STKVPAWGCCPASWKSFGSSCYFISSEEKV--WSKSEQNCVEMGAHLVVFNTEAEQNFIVQQLNESF-SYFLGLSDPQGNN
Mincle    LSCYNYGS-------GSVKNCCPLNWEYFQSSCYFFSTDTIS--WALSLKNCSAMGAHLVVINSQEEQEFLSYKKPKMR-EFFIGLSDQVVEG
BDCA-2    LTCVMEGK------DIEDWSCCPTPWTSFQSSCYFISTGMQS--WTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNS-SYFLGLSDPGGRR
CLEC-6    LKCIKEK-SELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKT--WAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRL-SYFLGLRDENAKG
SRCL          VPLALQNEPTPAPEDNSCPPHWKNFTDKCYYFSVEKEI--FEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRE-SHWIGLTDSEREN
Langerin                     QVVSQGWKYFKGNFYYFSLIPKT--WYSAEQFCVSRNSHLTSVTSESEQEFLYKTAGGLI--YWIGLTKAGMEG
Kupffer                      QMVLQGWKFNGGSLYYFSSVKKS--WHEAEQFCVSQGAHLASVASKEEQAFLVEFTSKVY--YWIGLTDRGTEG
 
 
 
CTLD - C-TERMINAL
 
LSECtin    GYQWVDGVSLSFS---------HWNQGEPND-----AWGRENCVMMLHTGL-----WNDAPCDSEKDGWICEKRHN-C
IgFcR      EFIWVDGSHVDYS---------NWAPGEPTS-----RSQGEDCVMMRGSGR-----WNDAFCDRKLGAWVCDRLAT-CTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS
DC-SIGN    TWQWVDGSPLLPSFKQ------YWNRGEPNN------VGEEDCAEFSGNG------WNDDKCNLAK-FWICKKSAASCSRDEEQFLSPAPATPNPPPA  
DC-SIGNR   TWQWVDGSPLSPSFQR------YWNSGEPNN------SGNEDCAEFSGSG------WNDNRCDVDN-YWICKKPAA-CFRDE
ASGPR-H1   PWKWVDGTDYETGFK-------NWRPEQPDDWYGHGLGGGEDCAHFTDDGR-----WNDDVCQRPY-RWVCETELDKASQEPPLL
ASGPR-H2   SWKWVDGTDYRHNYK-------NWAVTQPDNWHGHELGGSEDCVEVQPDGR-----WNDDFCLQVY-RWVCEKRRNATGEVA
ASGPR-M    AWKWVDGTDYATGFQ-------NWKPGQPDDWQGHGLGGGEDCAHFHPDGR-----WNDDVCQRPY-HWVCEAGLGQTSQESH
DCIR       HWQWVDQTPYNESST-------FWHPREPSD-------PNERCVVLNFRKSPKRWGWNDVNCLGPQ-RSVCEMMKIHL
Dectin-2   NWQWIDKTPYEKNVR-------FWHLGEPN-------HSAEQCASIVFWKPT-GWGWNDVICETRR-NSICEMNKIYL
Mincle     QWQWVDGTPLTKSLS-------FWDVGEPNN-----IATLEDCATMRDSSNP-RQNWNDVTCFLNY-FRICEMVGINPLNKGKSL
BDCA-2     HWQWVDQTPYNENVT-------FWHSGEPNN-------LDERCAIINFRSSE-EWGWNDIHCHVPQ-KSICKMKKIYI
CLEC-6     QWRWVDQTPFNPRRV-------FWHKNEPDN------SQGENCVVLVYNQD--KWAWNDVPCNFEA-SRICKIPGTTLN
SRCL       EWKWLDGTSPDYK---------NWKAGQPDNW-GHGHGPGEDCAGLIYAGQ-----WNDFQCEDVN-NFICEKDRETVLSSAL
Langerin   DWSWVDDTPFNKVQSAR-----FWIPGEPNN-----AGNNEHCGNIKAPSLQA---WNDAPCDKTF-LFICKRPYVPSEP
Kupffer    SWRWTDGTPFNAAQNKAPVVFGFWEKNQSDNWR-HKNGQTEDCVQIQQK-------WNDMTCDTPY-QWVCKK
 
CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)
 
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This page last updated:
Monday, 19 June 2006
Animal lectins home
Contact information: This site is supported by:
 
Kurt Drickamer
Division of Molecular Biosciences
Faculty of Natural Sciences
Imperial College London
 
Email: k.drickamer@imperial.ac.uk