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- Xenopus laevis (left) and Xenopus tropicalis
- Photo by Robert Grainger, University of
Virginia
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Alignment of intelectin domains from a selection
of known and predicted intelectin proteins. Residues that are identical in all or nearly all
of the aligned
sequences are highlighted in green.
Residues that are similar are highlighted in
cyan. Cysteine residues are highlighted in
yellow.
Asparagine residues that are potential N-glycosylation sites are highlighted in
orange. Equivalent
conserved asparagine residues in other proteins that are not part of an Asn-Xxx-Ser/Thr
glycosylation motif are highlighted in
pale orange. Potential sites of GPI-anchor attachment are highlighted in
red. The fibrinogen-like
region is marked and the sequence of human human fibrinogen beta is aligned
below the intelectin sequences.
Human (HS) intelectin 1
Q8WWA0 intelectin 2
Q8WWU7 Mouse (MM) intelectin a
O88310 intelectin b
Q80ZA0 Xenopus laevis (XL) xCGL
Q91719 xEEL
Q800K0,
Q5PPM0 xSL
Q8JJD0 xSL2
Q8JJC9 Ctenopharyngodon idella (CId) intelectin
Q4U121 Lampetra/Lathenteron japonica (LJ) serum lectin
Q98TC9 intelectin B
Q4W8M6 Danio rerio (DR)
XP_696482
XP_693651
XP_682917 Halocynthia roretzi (HR) galactose-specific lectin, not
in databases, see references Ciona
intestinalis (CIn) CGL-like
Q69HM9
5106
12299 |
Fibrinogen-like
HS INTL1 RSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMR---GKCTVGDRWSSQQGSKAVY
HS INTL2 RSCKEIKERCHSAGDGLYFLRTKNGVVYQTFCDMTSGGGGWTLVASVHENDMR---GKCTVGDRWSSQQGNKADY
MM INTLA RSCKEIKQEHTKAQDGLYFLRTKNGVIYQTFCDMTTAGGGWTLVASVHENNMR---GKCTVGDRWSSQQGNRADY
MM INTLB RSCKEIKQEDTKAQDGLYFLRTENGVIYQTFCDMTTAGGGWTLVASVHENNLR---GRCTVGDRWSSQQGNRADY
XL XCGL RSCKEIKDSNEEAQDGIYTLTSSDGISYQTFCDMTTNGGGWTLVASVHENNMA---GKCTIGDRWSSQQGNRADY
XL XEEL RSCNEIKSSDSRAPDGIYTLATEDGESYQTFCDMTTNGGGWTLVASVHENNMF---GKCTVGDRWSTQQGNMLQN
XL serum RNCREIKEFNNNAEDGIYTLRTGGGISYQTFCDMTADGGGWTLVASVHENNMF---GKCTVGDRWTSQQGNDPNY
XL SL2 RNCKEIKDSDSSAKDGIYNLITANGETYQAFCDMTTDGGGWTLVASVHENNMF---GKCTVGDRWSSQQGNNINN
DR 696482 RSCRELLKKYGHKKDGLYYLRSKDNEVYQTYCDMSTNGGGWTLVASVHENNIH---GSCTVGDRWTSQQGSSSYH
DR 693651 RSCKEIRDKYHVYEDGLYYLISSRGVLYQTFCDMTTAGGGWTLVASVHENNMY---GKCTVGDRWSSEQGSNENR
DR 682917 RSCLQIKKNHGATQDGMYILTTESGTYYQTFCDMTTAGGGWTLVASVHENNIN---GKCSFGDRWSSQQGNDQSL
CId ITLN RSCLEIKENHGGTQDGIYILTTESGTYYQAFCDMSTAGGGWTLVASVHENNIK---GKCSVGDRWSSQQGNDQNL
LJ serum RSCKEIKLKTKTKEDGVYCLQTKSGQFYQAFCDMNTNGGGWTLVASVHENNIA---AKCAIGDRWSSQLGSNPAV
LJ ITLN B HSCLEIKEKTK-SERG----ETKSGQSYQAFCDMNTNGGGWTLVASVHENNIA---AKCATGDRWTSQQGSNSEV
HR Gal KSCKQIKQNILSSTNGIYYIHDNEIGIYSVYCNMDVAEGGWTLVASVHENNMK---GRCTTGDRWSSEQGNSADH
CIn 5106 ESCDDLREIESEDGIYN--IFDYGGSEYSVFCDMSTDGGGWTFVASIHENDMK---GRCTAGDKWSSERGNNHNN
CIn 12299 VYTIHDTSGIPYPVYCDMEADNGGWTLVASVHENYIGEEVGRCTVGDRCSSQQGNSPLR
CIn CGL RSCHEIRNHVSGVYTIK---PKGSIFPFKTYCEMQDQEGGWTLVASIHENNIH---GKCSPGDKWSSEQGGITAL
HS FIBB ...KECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVI...
HS INTL1 PEGDG--NWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLG
HS INTL2 PEGDG--NWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSALLRYRTNTGFLQRLG
MM INTLA PEGDG--NWANYNTFGSAEAATSDDYKNPGYFDIQAENLGIWHVPNKSPLHNWRKSSLLRYRTFTGFLQHLG
MM INTLB PEGDG--NWANYNTFGSAEGATSDDYKNPGYFDIQAENLGIWHVPNNSPLHTWRNSSLLRYRTFTGFLQRLG
XL XCGL PEGDG--NWANYNTFGSAGGATSDDYKNPGYYDIEAYNLGVWHVPNKTPLSVWRNSSLQRYRTTDGILFKHG
XL XEEL PEGDG--NWANYATFGLPEGATSDDYKNPGYYDIEAKNLALWHVPNKTPMVMWRNSSILRYRTQNGFLTEEG
XL serum PAGDG--NWANYATFGLPGGATSDDYKNPGYYDITSSNLGLWHVPNNTPFSHWRNNSLLRYRTQNNFFSAEG
XL SL2 PGGEG--NWANYATFGLPEGATGDDYKNPGYYDISAKDLAIWHVPNNTPMTSWRSSSLLRYRTSNGFFPSEG
DR 696482 PAGDG--SWSNKVLFGTAEAATNDDYKNPGYYDIKAKDIAVWHVHNDNELEFWKVASVLRYHTNSNFLTPFG
DR 693651 PIGEG--TWANKVTFGAAEAATSDDYKNPGYYDIAAQDVSVWHVPNNMELEHWSTGSILRYHTENHFLTLHG
DR 682917 PEGEA--SWANTATFGSAEGSTSDDYKNPGYYDISAQDVSVWHVPNNEQLKKWTSSAILRYHTESQFLKEHG
CId ITLN PEGDG--AWANTATFGSAESSTSDDYKNPGYYDITAQDVSVWHIPNDEQLRNWTSSAILRYHTESQFLRQHG
LJ serum GFVDGDRSWANLNTFGRVESATDDDYKNPGYFDVDAEDISVWHVPNGTPLAQWKISSIFRYHTATEFLTPLG
LJ ITLN B PFVDGDKNWANLNTFGVPESATDDDYKNPGYYDLEANDIAVWHVPNGTPLPLWKASSLFRYHTESKFLGAFG
HR Gal PHGDG--FWENMATHGSPVSASSDDYKSPGYFSLQAQDIMIYHVPNDTPLHGFETKALFKYYTTSHFLTKYG
CIn 5106 PHGDG--NWENSNTFGRIEYATREDYKNRAYFQLNASNLMVWYVPNNTSFSDYKPSAYIRYRTANKTLAKLG
CIn 12299 PEGDA--SWQNLNTFGRAVSATSDDYKSQAYFELQARDVMVWQVPNDTPLSEFSSEAYLKYRTTNGFLTRYG
CIn CGL T-GSG--NWANRNTFGNLEAVTSQDYKNSAYMDVNGSNVMLWHVRNGVRLSDLSRRAHFKYLTTDNVLLNNG
HS INTL1 HNLFGIYQKY-PVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALC
HS INTL2 HNLFGIYQKY-PVKYRSGKCWNDNGPAIPVVYDFGDAKKTASYYSPYGQREFVAGFVQFRVFNNERAANALC
MM INTLA HNLFGLYKKY-PVKYGEGKCWTDNGPALPVVYDFGDARKTASYYSPSGQREFTAGYVQFRVFNNERAASALC
MM INTLB HNLFGLYQKY-PVKYGEGKCWTDNGPAFPVVYDFGDAQKTASYYSPSGRNEFTAGYVQFRVFNNERAASALC
XL XCGL GNLFSLYRIY-PVKYGIGSCSKDSGPTVPVVYDLGSAKLTASFYSPDFRSQFTPGYIQFRPINTEKAALALC
XL XEEL GNLFELYKKY-PVKYDIGKCLADNGPAVPVVYDLGSAEKTASLYSPNGRSEFTPGFVQFRAVNTERATLALC
XL serum GNLFNLYQKY-PLKFGIGTCPKDHGPAVPIVYDLGNPDLTTKYYSPSGRREFTAGFVHFRVFNAEKAALALC
XL SL2 GNLFNLYKKY-PVIYNTGSCQTNNGPAVPVLYDFGDPKTTSMYYSPNGRGEFIAGFVQFRVFNTERAPLALC
DR 696482 GNLYHFFKKY-HLQYGIGTCN-DRGISVPIVYDIGSDMRVNELYGESVRADFDTGYVTFRVFNNYQEAYAMC
DR 693651 GNLFKLFTKF-PVRFGIGSCNIDNGPAVPIVYDTGNEESTKKLYGPSARTQFEPGFITFRVLNNEKAAMALC
DR 682917 GNLYHLFKKY-PVRFGAGQCKSDMGPSSSVVYDTGDKDSTSNLYGPSVRNEFESGFITFRVFNTDQSAMAMC
CId ITLN GNLYHLFKKY-PVRFRAGQCKSDTGAVSPVVYDTGDKDSTTKLYGPSAGKEFESGFITFRVFNSDQAAMAMC
LJ serum GNLYFLYKIFYPLVYGSGTCPASNGPAIPIVYDFGNTISVASQVCPACLGGTLQGYVHLRVFNNERAPFALC
LJ ITLN B GNLYSFFKNFFPLTYNSGSCPTNNGPAYPIVYDYGSDGVINSLICPNCISGTTPGFVQLRVFNNEKAPFAIC
HR Gal GNLQQLFKVHYPRISKVYNMGTDNGPAIPVTWERGNTNSIWNEIGTVIQAETEGGYVQFRAVNHEKNVFSLC
CIn 5106 GNLQEIFKSY-PIKYLPKANYKN-GPSAPVVFDHGNLTDLMKNSVPRFFSEVEFGYVQFRALNEEKSAFAFC
CIn 12299 SNMFKLYSVYYPVKSGVYTFPTDSGPSIPVVFDQGSTISLLVHLPTLALTGIEAGYIQFRAIDVHRDAFAFC
CIn CGL KSLQRLYRDHVPLKLSVG(240 residues)VGSRQLMNETIPATERKTVQFGEIQFRAYNSIGFPNALC
HS INTL1 AGMRV-TG-CNTEHHCIGGGGYFPEASPQQ--CGDFSGFDWSGYGTHVGYSS---------SREITEAAVLLFYR
HS INTL2 AGIKV-TG-CNTEHHCIGGGGFFPQGKPRQ--CGDFSAFDWDGYGTHVKSSC---------SREITEAAVLLFYR
MM INTLA AGVRV-TG-CNTEHHCIGGGGFFPEGNPVQ--CGDFASFDWDGYGTHNGYSS---------SRKITEAAVLLFYR
MM INTLB AGVRV-TG-CNTEHHCIGGGGFFPEFDPEE--CGDFAAFDANGYGTHIRYSN---------SREITEAAVLLFYR
XL XCGL PGMKM-ES-CNVEHVCIGGGGYFPEADPRQ--CGDFAAYDFNGYGTKKFNSA---------GIEITEAAVLLFYL
XL XEEL AGVKV-KG-CNVEHHCIGGGGYIPEASPRQ--CGDFAALDWDGYGTNLGWSA---------SKQIIEAAVMLFYR
XL serum AGVKV-TG-CNTEHHCIGGGGYFAEGNPKQ--CGDFTGFDWDGYGTHQDWSN---------SKEITEAAVLLFYR
XL SL2 PGIKV-TG-CNAEHHCIGGGGFIPEGNPVQ--CGDFAAFDWNGYGTGYAWSS---------TKAITEAAVLLMYR
DR 696482 SGVRP-KG-CYAQYYCIGGGGYFPNTF-----CSDFAYLNANNGATNGYGA----------SKEIINAAVFIFYR
DR 693651 SGAKP-TD-CNTEHFCIGGGGHFPEGYPKQ--CGDFTGFDWNGYGTNTEWSA---------SREITEAAVLLFYR
DR 682917 SGIKP-SG-CNTQHYCIGGGGFF--AQPEQ--CGDFTALD----------------LKET-FKQPTQSAVLLFYR
CId ITLN SGIKP-TE-CNPQHYCIGGG-YFPQ--RQQ--CGDFTGLD----------------LREAASKQLTESSVLLFYR
LJ serum SGLRVLDN-CNTEHYCIGGAGYVPEQTPRQ--CGDFSAFDWSGIGTHVEWSA---------SKSLLEAAVFIFYR
LJ ITLN B SGIKIVSN-CNPETFCIGGAGYVPQGNPRQ--CGDFGAFDWNGYGTGVEWSA---------SKKLLESAVLIYYR
HR Gal PGVRIKTGSGNVEHACIGSTSNNIGHLHEEDYCGDYAARDW-------KWSANVKS-----TETLIEAATLIFYR
CIn 5106 PGVRIVASNLNVEHFCVGSTSYHVGHKGIVGYCGDFSAFDW---------STAKA------SDKLIHTTFFLFYR
CIn 12299 PGVRNKPTFNHPSQSCIGSAGGTRHNF----YCGDFSGFYHNGHAVGTGWSA---------DATLLNSSFLLFYR
CIn CGL AGFSTISTF--PERMCLGGINTYRRV-RKQ--CGDFAA--WEGNLNQYQNSNPEIATESGRSRNEINSTILLFVK
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- This page last updated:
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Friday, 20 October 2006
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Animal
lectins home
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| Contact information: |
This site
is supported by: |
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- Kurt Drickamer
- Division of Molecular Biosciences
- Faculty of Natural Sciences
- Imperial College London
-
- Email:
k.drickamer@imperial.ac.uk
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