Group III - Collectins

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

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SIGNAL SEQUENCE and CYSTEINE-RICH DOMAIN

 

MBP-A                     PSFPVLLLSVVTASCS-----KTKACADTQKTC-SMITCGIPVTN

MBP-C                 MSLFPSLPLLLLSMVAASYS-----ETVTCEDAQKTCPAVIACSSP

SP-A1                 MWLCPLALNLILMAASGAA-----------------CEVKDVCV

SP-A2                 MWLCPLALNLILMAASGAA-----------------CEVKDVCV

SP-D                  MLLFLLSALVLLTQPLGYLE--AEMKTYSHRTMPSAC-TLVMCSSVES

COL-L1        MNGFASLLRRNQFILLVLFLLQIQSLG------LDIDSRPTAEVC-ATHTISP

COL-K1        MRGNLALVGVLISLAFLSLLPSGHPQP------------AGDDAC-SVQILVP

 

 

 

COLLAGENOUS DOMAIN

 

MBP-A         GTPGRDGRDRPKGEKGEPGQGLRGLQGPPGKMGPPGNTGTSGIPGPRGQKGDRGDN

MBP-C         GINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKS

SP-A1         GSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLP

SP-A2         GSPGIPGTPGSHGLPGRDGRDGVKGDPGPPGPMGPPGETPCPPGNNGLPGAPGVPGERGEKGEAGERGPPGLP

SP-D          GLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGREGALGKQGNIGPQGKP

                 GPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLP

COL-L1        GPKGDDGEKGDPGEEGKHGKVGRMGPKGIKGELGDMGDRGNIGKTGPIGKKGDKGEKGLLGIPGEKGKAGTV

COL-K1        GLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLP

 

 

 

COILED-COIL NECK

 

MBP-A            SVAEAKLANLERKL*SLRSELDHTKKN*AFSLGKM

MBP-C           PDGDSSLAASERKALQTEMARIKKWLTFSLGKQ

SP-A1               AHLDEELQATLHDFRHQILQTRGALSLQGSIMT

SP-A2               AHLDEELQATLHDFRHQILQTRGALSLQGSIMT

SP-D                  DVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQS

COL-L1        CDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRE

COL-K1        CECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRE

 

HEPTAD REPEATS

 

 

CTLD

 

MBP-A         SGKKLFVTNGERMPFSKVKALCAGLQATVAAPKNAEENKAIQD----VAKDTAFLGITDEATEG

MBP-C         VGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQN----LIKEEAFLGITDEKTEG

SP-A1         VGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIAS-FVKKYNTYAYVGLTEGPSPG

SP-A2         VGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIAS-FVKKYNTYEYVGLTEGPSPG

SP-D          VGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQ-LVVAKNEAAFLSMTDSKTEG

COL-L1        TEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREG

COL-K1        TESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEG

 

MBP-A         QFMYLT-GGRLTYSNWKKDEPNDHGSGEDCVILLNNGLWNGISCTSSFIAICEFPA

MBP-C         QFVDLT-GNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI

SP-A1         DFRYSD-GTPVNYTNWYRGEPAGRG-KEQCVEMYTDGQWNDRNCLYSRLTICEF

SP-A2         DFRYSD-GTPVNYTNWYRGEPAGRG-KEQCVEMYTDGQWNDRNCLYSRLTICEF

SP-D          KFTYPT-GESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF

COL-L1        QYMFTDNTPLQNYSNWNEGEPSDPYGHEDCVEMLSSGRWNDTECHT MYFVCEFIKKKK

COL-K1        AFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

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This page last updated:	Wednesday, 18 October 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk