Group III - Collectins

Joint human/mouse sequence alignment

Human sequence alignment

Introduction

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SIGNAL SEQUENCE and CYSTEINE-RICH DOMAIN

 

human MBP-A                     PSFPVLLLSVVTASCS-----KTKACADTQKTC-SMITCGIPVTN

mouse MBP-A                        MLLLPLLPVLLCVVSVSSGSQTCEDTLKTC-SVIAC

human MBP-C                 MSLFPSLPLLLLSMVAASYS-----ETVTCEDAQKTCPAVIACSSP

mouse MBP-C                  MSIFTSFLLLCVVTVVYA-------ETLTEGVQNSCPVV-TCSSP

human SP-A1                MWLCPLALNLILMAASGAA------------------CEVKDVCV

human SP-A2                MWLCPLALNLILMAASGAA------------------CEVKDVCV

mouse SP-A                 MSLGSLAFTLFLTVVAGIK------------------CNGTEVCA

human SP-D                  MLLFLLSALVLLTQPLGYLE--AEMKTYSHRTMPSAC-TLVMCSSVES

mouse SP-D                   MLPFLSMLVLLVQPLGNLG--AEMKSLSQRSVPNTC-TLVMCSPTEN

human COL-L1        MNGFASLLRRNQFILLVLFLLQIQSLG------LDIDSRPTAEVC-ATHTISP

mouse COL-L1        MNGFRVLLRSNLSMLLLLALLHFQSLG------LDVDSRSAAEVC-ATHTISP

human COL-K1        MRGNLALVGVLISLAFLSLLPSGHPQP------------AGDDAC-SVQILVP

mouse COL-K1       MMMRDLALAGMLISLAFLSLLPSGCPQQ------------TTEDAC-SVQILVP 

COLLAGENOUS DOMAIN

 

human MBP-A       GTPGRDGRDRPKGEKGEPGQGLRGLQGPPGKMGPPGNTGTSGIPGPRGQKGDRGDN

mouse MBP-A       GRDGRDGPKGEKGEPGQGLRGLQGPPGKLGPPGSVGSPGSPGPKGQKGDHGDN

 

human MBP-C       GINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKS

mouse MBP-C       GLNGFPGKDGRDGAKGEKGEPGQGLRGLQGPPGKVGPTGPPGNPGLKGAVGPKGDRGDR

 

human SP-A1       GSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLP

human SP-A2       GSPGIPGTPGSHGLPGRDGRDGVKGDPGPPGPMGPPGETPCPPGNNGLPGAPGVPGERGEKGEAGERGPPGLP

mouse SP-A        GSPGIPGTPGNHGLPGRDGRDGIKGDPGPPGPMGPPGGMPGLPGRDGLPGAPGAPGEHGDKGEPGERGLPGFP

 

human SP-D        GLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDTGPSGPPGPPGVPGPAGREGALGKQGNIGPQGKP

                     GPKGEAGPKGEVGAPGMQGSAGARGLAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGESGLP

mouse SP-D        GLPGRDGRDGREGPRGEKGDPGLPGPMGLSGLQGPTGPVGPKGENGSAGEPGPKGERGLSGPPGLPGIPGPAGKEGPSGKQGNIGPQGKP

                     GPKGEAGPKGEVGAPGMQGSTGAKGSTGPKGERGAPGVQGAPGNAGAAGPAGPAGPQGAPGSRGPPGLKGDRGVPGDRGIKGESGLP

 

human COL-L1      GPKGDDGEKGDPGEEGKHGKVGRMGPKGIKGELGDMGDRGNIGKTGPIGKKGDKGEKGLLGIPGEKGKAGTV

mouse COL-L1      GPKGDDGERGDTGEEGKDGKVGRQGPKGVKGELGDMGAQGNIGKSGPIGKKGDKGEKGLLGIPGEKGKAGTI

 

human COL-K1      GLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGSVGRHGKIGPIGSKGEKGDSGDIGPPGPNGEPGLP

mouse COL-K1      GLKGDAGEKGDKGAPGRPGRVGPTGEKGDMGDKGQKGTVGRHGKIGPIGAKGEKGDSGDIGPPGPSGEPGIP 

 

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COILED-COIL NECK 

human MBP-A           SVAEAKLANLERKL*SLRSELDHTKKN*AFSLGKM

mouse MBP-A           RAIEEKLANMEAEIRILKSKLQLTNKLHAFSMGKK

 

human MBP-C          PDGDSSLAASERKALQTEMARIKKWLTFSLGKQ

mouse MBP-C          AEFDTSEIDSEIAALRSELRALRNWVLFSLSEK

 

human SP-A1              AHLDEELQATLHDFRHQILQTRGALSLQGSIMT

human SP-A2              AHLDEELQATLHDFRHQILQTRGALSLQGSIMT

mouse SP-A               AYLDEELQTASYEIKHQILQTMGVLSLQGSMLS

 

human SP-D                 DVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQS

mouse SP-D                 DSAALRQQMEALKGKLQRLEVAFSHYQKAALFPDGRS

 

human COL-L1       CDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRE

mouse COL-L1       CDCGRYRKFVGQLDISIARLKTSMKFVKNVIAGIRE

 

human COL-K1       CECSQLRKAIGEMDNQVSQLTSELKFIKNAVAGVRE

mouse COL-K1       CECSQLRKAIGEMDNQVTQLTTELKFIKNAVAGVRE

HEPTAD REPEATS

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CTLD - N-TERMINAL

 

human MBP-A        SGKKLFVTNGERMPFSKVKALCAGLQATVAAPKNAEENKAIQD----VAKDTAFLGITDEATEG

mouse MBP-A        SGKKLFVTNHEKMPFSKVKSLCTELQGTVAIPRNAEENKAIQE----VATGIAFLGITDEATEG

human MBP-C        VGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQN----LIKEEAFLGITDEKTEG

mouse MBP-C        VGKKYFVSSVKKMSLDRVKALCSEFQGSVATPRNAEENSAIQK----VAKDIAYLGITDVRVEG

human SP-A1        VGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIAS-FVKKYNTYAYVGLTEGPSPG

human SP-A2        VGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIAS-FVKKYNTYEYVGLTEGPSPG

mouse SP-A         VGDKVFSTNGQSVNFDTIREMCTRAGGHIAAPRNPEENEAIAS-ITKKYNTYPYLGVIEGQTPG

human SP-D         VGEKIFKTAGFVKPFTEAQLLCTQAGGQLASPRSAAENAALQQ-LVVAKNEAAFLSMTDSKTEG

mouse SP-D         VGDKIFRTADSEKPFEDAQEMCKQAGGQLASPRSATENAAIQQ-LITAHNKAAFLSMTDVGTEG

human COL-L1       TEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEAANTLIADYVAKSGFFRVFIGVNDLEREG

mouse COL-L1       TEEKFYYIVQEEKNYRESLTHCRIRGGMLAMPKDEVVNTLIADYVAKSGFFRVFIGVNDLEREG

human COL-K1       TESKIYLLVKEEKRYADAQLSCQGRGGTLSMPKDEAANGLMAAYLAQAGLARVFIGINDLEKEG

mouse COL-K1       TESKIYLLVKEEKRYADAQLSCQARGGTLSMPKDEAANGLMASYLAQAGLARVFIGINDLEKEG

 

 

CTLD - C-TERMINAL

 

human MBP-A        QFMYLT-GGRLTYSNWKKDEPNDHGSGEDCVILLNNGLWNGISCTSSFIAICEFPA

mouse MBP-A        QFMYVT-GGRLTYSNWKKDEPNNHGSGEDCVIILDNGLWNDISCQASFKAVCEFPA

human MBP-C        QFVDLT-GNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI

mouse MBP-C        SFEDLT-GNRVRYTNWNDGEPNNTGDGEDCVVILGNGKWNDVPCSDSFLAICEFSD

human SP-A1        DFRYSD-GTPVNYTNWYRGEPAGRG-KEQCVEMYTDGQWNDRNCLYSRLTICEF

human SP-A2        DFRYSD-GTPVNYTNWYRGEPAGRG-KEQCVEMYTDGQWNDRNCLYSRLTICEF

mouse SP-A         DFHYLD-GASVNYTNWYPGEPRGRG-KEKCVEMYTDGKWNDKGCLQYRLAICEF

human SP-D         KFTYPT-GESLVYSNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF

mouse SP-D         KFTYPT-GEPLVYSNWAPGEPNNNGGAENCVEIFTNGQWNDKACGEQRLVICEF

human COL-L1       QYMFTDNTPLQNYSNWNEGEPSDPYGHEDCVEMLSSGRWNDTECHT-MYFVCEFIKKKK

mouse COL-L1       QYVFTDNTPLQNYSNWKEEEPSDPSGHEDCVEMLSSGRWNDTECHLTMYFVCEFVKKKK

human COL-K1       AFVYSDHSPMRTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHTTMYFMCEFDKENM

mouse COL-K1       AFVYSDRSPMQTFNKWRSGEPNNAYDEEDCVEMVASGGWNDVACHITMYFMCEFDKENL

 

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

 

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This page last updated:	Wednesday, 18 October 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk