Group II - Type II
receptors
- Joint human/mouse sequence alignment
|
Mammalian
proteins containing CTLDs
|
If alignments appear scrambled please maximize the width of
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* pseudogene
- CYTOPLASMIC TAIL and TRANSMEMBRANE
REGION
-
- human LSECtin MDTTRYSKWGGSSEEVPGGPWGRWVHWSRRPLFLALAVLVTTVLWAVILSILL
-
mouse LSECtin MNTGEYNKLGSAIEEVSRGQLGRWECYKQRLFFLVLALLVATVLWALILSTLL
- human CD23
MEEGQYSEIEELPRRRCC--RRGTQIVLLGLVTAALWAGLLTLLLLWHW
-
mouse CD23 MEENEYSGYWEPPRKRCCCARRGTQLMLVGLLSTAMWAGLLALLLLWHW
- human DC-SIGN MSDSKEPRLQQLGLLEEE---------QLRGLGFRQTRGYKSLAGCLGH--GPLVLQLLSFTLLAG----LLVQVS
- human DC-SIGNR
MSDSKEPRVQQLGLLEEDPTT-SGIRLFPRDFQFQQIHGHKSSTGCLGH--GALVLQLLSFMLLAGVLVAILVQVS
-
mouse SIGNR1
MSDSTEAKMQPLSSMDDDELMVSGSRYSIKSSRLRPNSGIKCLAGCSGHSQVPLVLQLLSFLFLAGLLLIILFQVS
-
mouse SIGNR3
MSDSMESKTQQVVIPEDEECLMSGTRYSDISSRLQTKFGIKSLAEYTKQSRNPLVLQLLSFLFLAGLLLIILILVS
-
mouse SIGNR4
MRAPQMGSLGFLDKGH--IPLVLQLLFLILFTGLLVAIIIQVS
-
mouse SIGNR5
MSDSKEMGKRQLRPLDEELLTSSHTRHSIKGFGFQTNSGFSSFTGCLVHSQVPLALQVLFLAVCSVLLVVILVKVY
- mouse SIGNR7 MAGEPEFHQPKNHEEEVTSGEQGFAEHDPEGLVCSSKSLQGHLTQVPWLLLLLISLGLFLLMLATLVQVS
- mouse SIGNR8 MAGEPEFHQSKNHEEEVTSGEQGFAEHDPEGLICSSKSLQGHLTQVPWLLLLLISLGLFLLMLATLVQVS
-
- human Langerin
MT-VE-K-EAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQAVLYP
-
mouse Langerin
MPEAEMKEEAPEAHFTVDKQNISLWPREPPPKQDLSPVLRKPLCICVAFTCLALVLVTSIVLQAVFYP
-
mouse Kupffer
MKEAELNRDMARYCTDNQCVSLQPQGLGPKSAALMAPRTLRHVQVILALMVVTVIFSLLALFVV
-
- human ASGPR-H1 MTKEYQDLQHLDNEESDHHQLR------------------KGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGS
-
mouse ASGPR-H1 MTKDYQDFQHLDNDNDHHQLRR-------------------GPPPTPRLLQRLCSGSRLLLLSSSLSILLLVVVCVITS
- human ASGPR-H2 MAKDFQDIQQLSSEENDHPFHQGEGPGTRRLNPRRGNPFLKGPPPAQPLAQRLCSMVCFSLLALSFNILLLVVICVTGS
-
mouse ASGPR-H2
MEKDCQDIQQLDSEENDHQLSGDDEHGSHVQDPRIENPHWKGQPLSRPFPQRLCSTFRLSLLALAFNILLLVVICVVSS
-
mouse MGL1
MIYENLQNSRIEEKTQEPGK---------------------APSQSFLWRILSWTHLLLFSLGLSLLLLVVVSVIGS
- mouse MGL2
MTMRYENFQNLEREEKNQEMRNGDKKGGMESPKF-------ALIPSQSFLWRILSWTHLLLFSLGLSLLLLVVISVIGS
- human MGL MTRTYENFQYLENKVKVQGFKN-------------------GPLPLQSLLQRLRSGPCHLLLSLGLGLLLLVIICVVGF
- human SRCL
MKDDFAEEEEVQSFGYKRFGI--------------QEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGY
-
mouse SRCL
MKDDFAEEEEVQSFGYKRFGI--------------HEGTQCTKCINNWALKFSIVLLYILCALLTITVAILGY
- human DCIR
MTSEITYAEVRFKNEFKSSGINTAS----------------SAASKERTAPLKSNTGFPKLLCASLLIFFLLLAISFFIAFVIFF
-
mouse DCIR1
MASEITYAEVKFKNESNSLHTYSES----------------PAAPREKPIRDLRKPGSPSLLLTSLMLLLLLLAITFLVAFIIYF
- mouse DCIR2
MASEITYAEVRITNESDSLDTYSKC----------------PAAPREKPIRDLRKPGSPSLLLTSLMLLLLLLAITFLVAFIIYF
mouse
DCIR3 MFSENIYVNTNFKNKVDSSDIDTDS----------------WPAPQRKNTSQKSCHKFSKVLFTSLIIYFLLLTILFSGALITLF
mouse
DCIR4 MALPNIYTDVNFKNQPVSSGLISDSSSCTVSDS--------SSALPKKTTIHKSNPGFPR-LLLALWIFFLLLAILFSVALIILF-
mouse DCAR1 MMQERPAQG--QVVCWSLRLWMAALISILLLSTCFIASCVV
mouse
DCAR2 MVQERQLQG--KAVSWSLRLWSAAVISILLLSTCFIASCV-
human
Dectin-2 MMQEQQPQSTEKRGWLSLRLWSVAGISIALLSACFIVSCVV-
mouse
Dectin-2 MVQERQSQG--KGVCWTLRLWSAAVISMLLLSTCFIASCVV
human BDCA-2
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVV- human MCL
MGLEKPQSKLEGGMHPQLIPSVIAVVFILLLGVCFIASCLV
-
mouse MCL
MWLEESQMKSKGTRHPQLIPCVFAVVSISFLSACFISTCLV
-
human Mincle
MNSSKSSETQCTERGCF-SSQMFLWTVAGIPILFLSACFITRCVVTF
-
mouse Mincle
MNSTKSPASHHTERGCFKNSQVLSWTIAGASILFLSGCFITRCVVTY
-
- POTENTIAL INTERNALIZATION
SIGNAL
TRANSMEMBRANE DOMAIN
ITIM
POSITIVELY-CHARGED RESIDUE IN TM REGION
Return
to top ↑
- NECK REGION: COILED-COIL and
COLLAGEN-LIKE DOMAINS
-
- human LSECtin
SKASTERAALLDGHDLLRTNASKQTAALGALKEEVGDCHSCCSGTQAQLQTTRAELGEAQAKLMEQESALRELRERVTQGLAEAGRGREDVRTELFRALEAVRLQN
-
mouse LSECtin
SSASSKLRVLLSHQDLLRTNASEQKMTLSSLKDDIGACRNCCSVTKAQLQTTLAEFKDIQAKLMEQESILKELQERVTQDLAKASRDRENIRSELFQALEAVKRQN
-
human CD23
DTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQ
-
ISQELEELRAEQQRLKSQDLE
-
LSWNLNGLQADLSSFKSQELNERNE
-
ASDLLERLREEVTKLRMELQVSSG
-
-
mouse CD23
ETEKNLKQLGDTAIQNVSHVTKDLQKFQSNQLAQKSQ
-
VVQMSQNLQELQAEQKQMKAQDSRLSQN
-
LTGLQEDLRNAQSQNSKLSQNLNRLQDDLVN
-
IKSLGLNEKRTASDSLEKLQEEVAKLWIEILISKG
-
- human DC-SIGN KVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQE
-
IYQELTQLKAAVGELPEKSKLQE
-
IYQELTRLKAAVGELPEKSKLQE
-
IYQELTWLKAAVGELPEKSKMQE
-
IYQELTRLKAAVGELPEKSKQQE
-
IYQELTRLKAAVGELPEKSKQQE
-
IYQELTRLKAAVGELPEK
- human DC-SIGNR
KVPSSLSQEQSEQDAIYQNLTQLKAAVGELSEKSKLQE
-
IYQELTQLKAAVGELPEKSKLQE
-
IYQELTRLKAAVGELPEKSKLQE
-
IYQELTRLKAAVGELPEKSKLQE
-
IYQELTRLKAAVGELPEKSKLQE
-
IYQELTELKAAVGELPEKSKLQE
-
IYQELTQLKAAVGELPDQSKQQQ
-
IYQELTDLKTAFE
-
-
mouse SIGNR1
KTPNTERQKEQEKILQELTQLTDELTSRIPISQGKNES
-
MQAKITEQLMQLKTELLSRIPIFQGQNES
-
IQEKISEQLMQLKAELLSKISSFPVKDDS
-
KQEKIYQQLVQMKTELF
-
-
mouse SIGNR2
MRMHTRLQFLKRVSNVAYSHGQEQAKKEKVYKEMTQLKSQIN
-
mouse SIGNR3
KVPSS-E-VQNKIY-QELM-----QLKAEVHD
- mouse SIGNR4
KMPSS-EEIQWEHTKQEKMYKDLSQLKSEV-D
-
mouse SIGNR5 KIPSSQEENN-----QMNVYQELTQLKAGV-D
-
mouse SIGNR7
RIRAYSQGQTQDQQGSSSLDKVAVPREQTHSGLEQIQQIQQQLTQFNASLA
- mouse SIGNR8
RIRAYSQGQTQDQQGSSSLDKVAVPREQTHSGLEQIQQIQQQLTQFNASLGPRQKGEEKPATELSVCSVA
- mouse SIGNR6*
ASQQVFLHVFALRNGRTPGKGIPQLLGPVVVSWASEMFPWMTMRVQAPSIQISSDRTQPLNNGLTRQAVCSNPHLMINTVEGLMATGSVEAFPALVLPFVVEYDPD
-
DNGKYRKHQGEKDNKEESQATQGRWW*CHLWQLQIIHRGQEYILM*LFFFWGPHSSQLKQLEGNDIMVSREIPSDGGSAEVIALGEPDPGHLNAVPPLMFAINIHH
-
YHQMPLDIANHVEDLSTFNVFIVFSCPRGNSQEHDQEKLHIQQKLDQLKA
-
- human Langerin RFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVRSQFLKLKTSV
-
EKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLENMSKLLKRQNDIL
-
-
mouse Langerin RLMGKILDVKSDAQMLKGRVDNISTLGSDLKTERGRVDDAEVQMQIVNTTLKRVRSQILSLETSM
-
KIANDQLQILTMSWGEVDSLSAKIPELKRDLDKASALNTKVQGLQNSLENVNKLLKQQSDIL
-
-
- human Kupffer* ANAEIQGLKENLQNTNALNSQTQAFIKSSFDNTSAEIQFLRGHLERAGDEIHVLKRDLKMVTAQTQKANGRLDQTDTQIQVFKSEMENVNT
-
LNAQIQVLNGHMKNASREIQTLKQGMK-NASALTSQTQMLDSNLQKASAEIQRLRGDLENTKALTMEIQQEQSRLKTLHVVITSQEQLQRTQS
-
- mouse Kupffer ASQPWRPEWNKEPPSLLLRGSNNSGHDNHSQFVRETEMQVAIQRLRDYEENSSSCHKEVQILKYQMDNVSSLVQLLGSHLEDVNADILQTKD
-
VLKESGALALETQALRSSLEVASADIHSLRGDLEKANAMTSQTRGLLKSSTENTSAELHVLGRGLEEAQSEIQALRGSLQSANDLSSQTQGF
-
LQHSMDNISAQIQTVRDGMERAGEKMNSLKKELETLTAQTQKANGHLEQTDAQIQGLKAELKSTSSLNSRIEVVNGQMKDASRELQTLRRDL
- SDVSALKSNVQMLQSNLQRAKTEMQTLKADLQATKALTAKIQGEQNRLGALQEAVAAQKQEQKTQNQVL
-
-
- human ASGPR-H1 QN-----SQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRS
-
mouse ASGPR-H1 QN-----SQLREDLLALRQNFSNLTVSTEDQVKALSTQGSSVGRKMKLVESKLEKQQKDLTEDHSSLLLHVKQLVSDVRS
- human ASGPR-H2 QSEGHRGAQLQAELRSLKEAFSNFSSSTLTEVQAISTHGGSVGDKITSLGAKLEKQQQDLKADHDALLFHLKHFPVDLRF
-
mouse ASGPR-H2 QS-----IQLQEEFRTLKETFSNFSSSTLMEFGALDTLGGSTNAILTSWLAQLEEKQQQLKADHSTLLFHLKHFPMDLRT
-
mouse MGL1 QN-----SQLRRDLGTLRATLDNTTSKIKAEFQSLDSRADSFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTVEKREQALKTDLSDLTDHVQQLRKDLKA
- mouse MGL2 QN-----SQLRRDLGTLRAILDNTTSKIKAEFQSLDSRADNFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTLEKREQALKTDLSDLTDHVQQLETDLKA
- human MGL QN-----SKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAVHSEMLLR------------------------VQQLVQDLKK
- human SRCL KVVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSE
-
LSTFRSDILDLRQQLREITEKTSKNKDT
-
LEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTNLQQDTSVLQGNLQNQMYSHNV
-
VIMNLNNLNLTQVQQRNL
-
ITNLQRSVDDTSQAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDT
-
LEDMNSQLNSFTGQMENITTISQANEQNLKDLQDLHKDAENRTAIK
-
FNQLEERFQLFETDIVNIISNISYTAHHLRTLTSNLNEVRTTCTDTLTKHTDD
-
LTSLNNTLANIRLDSVSLRMQQDLMRSR
-
LDTEVANLSVIMEEMKLVDSKHGQL
-
IKNFTILQ
-
-
mouse SRCL
KVVEKMDNVSDGMETSHQTYDNKLTAVESDLKKLGDQAGKKALSTNSE
-
LSTFRSDILDLRQQLQEITEKTSKNKDT
-
LEKLQANGDSLVDRQSQLKETLQNNSFLITTVNKTLQAYNGYVTNLQQDTNVLQGNLQSQMYSQSV
-
VIMNLNNLNLTQVQQRNL
-
ISNLQQSVDDTSLAIQRIKNDFQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDT
-
LEDMNSQLSSFTGQMDNITTISQANEQSLKDLQDLHKDTENRTAVK
-
FSQLEERFQVFETDIVNIISNISYTAHHLRTLTSNLNDVWTTCTDTLTRHTDD
-
LTSLNNTLVNIRLDSISLRMQQDMMRSK
-
LDTEVANLSVVMEEMKLVDSKHGQL
-
IKNFTILQ
-
- human SRCL
GPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKP
-
GPQGPSGDPGPPGPPGKEGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAV
-
-
mouse SRCL
GPPGPRGPKGDRGSQGPPGPTGNKGQKGEKGEPGPPGPAGERGTIGPVGPPGERGSKGSKGSQGPKGSRGSPGKP
-
GPQGPSGDPGPPGPPGKDGLPGPQGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAM
-
- human DCIR QKYSQLLEKKTTKELVHTT
-
mouse DCIR1
QKYSQLLEEKKAAKNIMHNE
- mouse DCIR2
QKYSQLLEEKEAAKNIMYKE
mouse DCIR3
TKYSQLLEEKMIIKELNYTE
mouse DCIR4
QMYSDLLEEKYTLERLNHAR- mouse
DCAR1 TYQLMMNKPNRRLSELHTYHSN
human
Dectin-2 TYHFTYGETGKRLSELHSYHSS
-
mouse Dectin-2 TYQFIMDQPSRRLYELHTYHSS
human BDCA-2
PHNFMYSKTVKRLSKLREYQQYHPS
- human MCL THHNFSRCKRGTGVHKLEHHAK
-
mouse MCL
THHYFLRWTRGSVVKLSDYHTR
-
human Mincle RIFQTCDEKKFQLPENFTE
-
mouse Mincle
RSSQISGQNLQPHRNIKE
-
-
-
HEPTAD REPEAT
COLLAGENOUS DOMAIN
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CTLD -
N-TERMINAL-
- human LSECtin
NSCEPCPTSWLSFEGSCYFFSVPKTT--WAAAQDHCADASAHLVIVGGLDEQGFLTRNT-RGRGY-WLGLRAVRHLGKVQ
-
mouse LSECtin
SSCEQCPPSWLPFQGSCYYFSETQAT--WDTAQSYCGGQGAHLVIVRGLNEQGFLSQHT-RGRGY-WLGLRAVRHLNKIQ
-
human CD23
FVCNTCPEKWINFQRKCYYFGKGTKQ--WVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTG--SWIGLRNLDLKG
-
mouse CD23
TACNICPKNWLHFQQKCYYFGKGSKQ--WIQARFACSDLQGRLVSIHSQKEQDFLMQHINKKD--SWIGLQDLNMEG
- human DC-SIGN
RLCHPCPWEWTFFQGNCYFMSNSQRN--WHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEG
- human DC-SIGNR
RLCRHCPKDWTFFQGNCYFMSNSQRN--WHDSVTACQEVRAQLVVIKTAEEQNFLQLQTSRSNRFSWMGLSDLNQEG
-
mouse SIGNR1
RLCRLCPWDWTFLLGNCYFFSKSQRN--WNDAVTACKEVKAQLVIINSDEEQTFLQ-QTSKAKGPTWMGLSDLKKEA
-
mouse SIGNR2
RLCRPCPWDWTVFQGNCYFFSKFQQN--WNDSVNACRKLDAQLVVIKSDDEQSFLQ-QTSKEKGYAWMGLSDLKHEG
-
mouse SIGNR3
GLCQPCARDWTFFNGSCYFFSKSQRN--WHNSTTACQELGAQLVIIETDEEQTFLQ-QTSKARGPTWMGLSDMHNEA
-
mouse SIGNR4
RLCRLCPWDWTFFNGNCYFFSKSQRD--WHDSMTACKEMGAQLVIIKSHEEQSFLQ-QTSKKNSYTWMGLSDLNKEG
-
mouse SIGNR5
RLCRSCPWDWTHFQGSCYFFSVAQKS--WNDSATACHNVGAQLVVIKSDEEQNFLQ-QTSKKRGYTWMGLIDMSKES
-
mouse SIGNR7
GLCRPCPWDWELFQGSCYLFSRTLGS--WETSASSCEDLGAHLVIVNSVSEQQFLKYWHIRKNQLTWIGLSDHRSEG
- mouse SIGNR8
GLCRPCPWDWELFQGSCYLFSRTLGS--WETSASSCEDLGAHLVIVNSVSEQRFMKYWNVRKNQRSWIGLSDHIHEG
-
mouse SIGNR6*
GLCYFFSTFQKI--WRESVTACKDMGANLVSIESDEEQNFFH-RTSKKKGTTWLGLSDSKEEG
- human Langerin
QVVSQGWKYFKGNFYYFSLIPKT--WYSAEQFCVSRNSHLTSVTSESEQEFLYKTAGGLIY--WIGLTKAGMEG
-
mouse Langerin
EMVARGWKYFSGNFYYFSRTPKT--WYSAEQFCISRKAHLTSVSSESEQKFLYKAADGIPH--WIGLTKAGSEG
- human Kupffer*
QMVLQGWKFNGGSLYYFSSVKKS--WHEAEQFCVSQGAHLASVASKEEQAFLVEFTSKVYY--WIGLTDRGTEG
-
mouse Kupffer
QLIAQNWKYFNGNFYYFSRDKKP--WREAEKFCTSQGAHLASVTSQEEQAFLVQTTSSGDH--WIGLTDQGTEG
-
- human ASGPR-H1 LSCQMAALQGNG----SERTCCPVNWVEHERSCYWFSRSGKA--WADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVN--TWMGLHD--QNG
-
mouse ASGPR-H1
LSCQMAAFRGNG----SERICCPINWVEYEGSCYWFSSSVRP--WTEADKYCQLENAHLVVVTSRDEQNFLQRHMGPLN--TWIGLTD--QNG
- human ASGPR-H2 VACQMELLHSNG----SQRTCCPVNWVEHQGSCYWFSHSGKA--WAEAEKYCQLENAHLVVINSWEEQKFIVQHTNPFN--TWIGLTD--SDG
-
mouse
ASGPR-H2 LTCQLAYFQSNG------TECCPVNWVEFGGSCYWFSRDGLT--WAEADQYCQLENAHLLVINSREEQDFVVKHRSQFH--IWIGLTD--RDG
-
mouse MGL1
LTCQLANLKNNG----SEVACCPLHWTEHEGSCYWFSESEKS--WPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVV--SWIGLTD--QNG
- mouse MGL2 LTCQLANLKNNG----SEVACCPLHWTEHEGSCYWFSESEKS--WPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVL--SWMGLTD--QNG
- human MGL LTCQVATLNNNGEEASTEGTCCPVNWVEHQDSCYWFSHSGMS--WAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAY--TWMGLSD--PEG
- human SRCL VPLALQNEPTPAPEDNSCPPHWKNFTDKCYYFSVEKEI--FEDAKLFCEDKSSHLVFINTREEQQWIKKQMVGRESH-WIGLTDSEREN
-
mouse SRCL
EPLALQNEPTPASEVNGCPPHWKNFTDKCYYFSLEKEI--LEDAKLFCEDKSSHLVFINSREEQQWIKKHTVGRESH-WIGLTDSEQES
-
- human DCIR
LECVKKNM----PVEETAWSCCPKNWKSFSSNCYFISTES--ASWQDCEKDCARMEAHLLVINTQEEQDFIFQNLQEESAY-FVGLSDPEGQR
-
mouse
DCIR1 LNCTKSVS----PMEDKVWSCCPKDWRLFGSHCYLVPTVSSSASWNKSEENCSRMGAHLVVIQSQEEQDFITGILDTHAAY-FIGLWDT-GHR
- mouse DCIR2
LNCIKNGS----LMEDKVWSCCPKDWKPFVSHCYFILNDSK-ASWNESEEKCSHMGAHLVVIHSQAEQDFITSNLNTSAGY-FIGLLDA-GQR
mouse
DCIR3 LECTKWAS----LLEDKVWSCCPKDWKPFGSYCYFTSTDLV-ASWNESKENCFHMGAHLVVIHSQEEQDFITGILDTGTAY-FIGLSNP-GDQ
mouse
DCIR4 LHCVKNHS----SVEDKVWSCCPKNWKPFDSHCYFTSRDT--ASWSKSEEKCSLRGAHLLVIQSQEEQDFITNTLNPRAAY-YVGLSDPKGHG
mouse
DCAR1 LICFSEGT----TVSEKVWSCCPKDWKPFGSYCYFTSTDSR-ASQNKSEEKCSLRGAHLVVIHSQEEQDFITRMLDTAAGY-FIGLSDV-GNS- mouse
DCAR2 DKVWSCCPKDWKLFGSHCYLVPTVFSSASWNKSEENCSRMGAHLVVIHSQEEQDFITGILDIHAAY-FIGLWDT-GHR
-
human Dectin-2
LTCFSEGV----STKVPAWGCCPASWKSFGSSCYFISSEEKV--WSKSEQNCVEMGAHLVVFNTEAEQNFIVQQLNESFSY-FLGLSDPQGNN
-
mouse Dectin-2
LTCFSEGT------MEKMWGCCPNHWKSFGSSCYLISTKENF--WSTSEQNCVQMGAHLVVINTEAEQNFITQQLNESLSY-FLGLSDPQGNG
human BDCA-2 LTCVMEGK------DIEDWSCCPTPWTSFQSSCYFISTGMQS--WTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSY-FLGLSDPGGRR
- human MCL LKCIKEKS-ELKSAEGSTWNCCPIDWRAFQSNCYFPLTDNKT--WAESERNCSGMGAHLMTISTEAEQNFIIQFLDRRLSY-FLGLRDENAKG
-
mouse MCL VTCIREE--PQPGATGGTWTCCPVSWRAFQSNCYFPLNDNQT--WHESERNCSGMSSHLVTINTEAEQNFVTQLLDKRFSY-FLGLADENVEG
-
human Mincle LSCYNYGS-------GSVKNCCPLNWEYFQSSCYFFSTDTIS--WALSLKNCSAMGAHLVVINSQEEQEFLSYKKPKMREF-FIGLSDQVVEG
-
mouse Mincle LSCYSEAS-------GSVKNCCPLNWKHYQSSCYFFSTTTLT--WSSSLKNCSDMGAHLVVIDTQEEQEFLFRTKPKRKEF-YIGLTDQVVEG
-
- Return
to top ↑
-
-
- CTLD - C-TERMINAL
-
-
human LSECtin
GYQWVDGVSLSFS---------HWNQGEPND-----AWGRENCVMMLHTGL-----WNDAPCDSEKDGWICEKRHN--C
mouse LSECtin GYRWVDGASLNFS---------HWNSGEPND-----SRGHEDCIMMLHSGL-----WNDAPCTNERDGWICEKRSS--CY
human CD23
EFIWVDGSHVDYS---------NWAPGEPTS-----RSQGEDCVMMRGSGR-----WNDAFCDRKLGAWVCDRLAT--CTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS -
mouse CD23
EFVWSDGSPVGYS---------NWNPGEPNN-----GGQGEDCVMMRGSGQ-----WNDAFCRSYLDAWVCEQLAT--CEISAPLASVTPTRPTPKSEP
- human DC-SIGN TWQWVDGSPLLPSFKQ------YWNRGEPNN------VGEEDCAEFSGNG------WNDDKCNLAK-FWICKKSAAS-CSRDEEQFLSPAPATPNPPPA
- human DC-SIGNR TWQWVDGSPLSPSFQR------YWNSGEPNN------SGNEDCAEFSGSG------WNDNRCDVDN-YWICKKPAA--CFRDE
-
mouse SIGNR1
TWLWVDGSTLSSRFQK------YWNRGEPNN------IGEEDCVEFAGDG------WNDSKCELKK-FWICKKSATP-CTEG
-
mouse SIGNR2
RWHWVDGSHLLFSFMK------YWNKGEPNN------EWEEDCAEFRGDG------WNDAPCTIKK-YWICKKSAMS-CTEK
-
mouse SIGNR3
TWHWVDGSPLSPSFTR------YWNRGEPNN------VGDEDCAEFSGDG------WNDLSCDKLL-FWICKKVSTSSCTTK
-
mouse SIGNR4
EWYWLDGSPLSDSFEK------YWKKGQPNN------VGGQDCVEFRDNG------WNDAKCEQRK-FWICKKIATT-CLSKW
-
mouse SIGNR5
TWYWVDGSPLTLSFMK------YWSKGEPNN------LGEEDCAEFRDDG------WNDTKCTNKK-FWICKKLSTS-CPSK
-
mouse SIGNR7
SWQWVDDTPLKLS---------FWKEGEPNN------EGDEDCVVMAEDK------WNDSRCTANN-FWVCEQPSAP-CPGY
-
mouse
SIGNR8 SWQWVDGSALKFS---------FWKEGEPNN------DGDEDCVELFMDD------WNDNKCTEQN-FWVCEQPSAP-CPHH
- mouse SIGNR6*
QWLRVDGSPLQWSN--------YWSRWEPNN------QYDEDCVELSDSG------WNDISCFSEK-LWICKRSASP-CSK
- human Langerin DWSWVDDTPFNKVQSAR-----FWIPGEPNN-----AGNNEHCGNIKAPSLQA---WNDAPCDKTF-LFICKRPYVPSEP
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mouse Langerin
DWYWVDQTSFNKEQSRR-----FWIPGEPNN-----AGNNEHCANIRVSALKC---WNDGPCDNTF-LFICKRPYVQTTE
- human Kupffer* SWRWTDGTPFNAAQNKAPVVFGFWEKNQSDNWR-HKNGQTEDCVQIQQK-------WNDMTCDTPY-QWVCKK
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mouse Kupffer
IWRWVDGTPFNNAQSKG-----FWGKNQPDNWR-HRNGEREDCVHVRQQ-------WNDMACGSSY-PWVCKKSTGWSAARVG
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- human ASGPR-H1 PWKWVDGTDYETGFK-------NWRPEQPDDWYGHGLGGGEDCAHFTDDGR-----WNDDVCQRPY-RWVCETELDKASQEPPLL
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mouse ASGPR-H1 PWKWVDGTDYETGFQ-------NWRPEQPDNWYGHGLGGGEDCAHFTTDGR-----WNDDVCRRPY-RWVCETKLDKAN
- human ASGPR-H2 SWKWVDGTDYRHNYK-------NWAVTQPDNWHGHELGGSEDCVEVQPDGR-----WNDDFCLQVY-RWVCEKRRNATGEVA
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mouse ASGPR-H2 SWKWVDGTDYRSNYR-------NWAFTQPDNWQGHEQGGGEDCAEILSDGH-----WNDNFCQQVN-RWVCEKRRNITH
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mouse MGL1 PWRWVDGTDFEKGFK-------NWAPLQPDNWFGHGLGGGEDCAHITTGGP-----WNDDVCQRTF-RWICEMKLAKES
- mouse MGL2 PWRWVDGTDFDKGFK-------NWRPLQPDNWHGHMLGGGEDCAHFSYDGR-----WNDDVCQRHY-HWICETELGKASSAHSPQLIASVP
- human MGL AWKWVDGTDYATGFQ-------NWKPGQPDDWQGHGLGGGEDCAHFHPDGR-----WNDDVCQRPY-HWVCEAGLGQTSQESH
- human SRCL EWKWLDGTSPDYK---------NWKAGQPDNW-GHGHGPGEDCAGLIYAGQ-----WNDFQCEDVN-NFICEKDRETVLSSAL
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mouse SRCL
EWKWLDGSPVDYK---------NWKAGQPDNW-GSGHGPGEDCAGLIYAGQ-----WNDFQCDEIN-NFICEKEREAVPSSIL
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- human DCIR
HWQWVDQTPYNESST-------FWHPREPSD-------PNERCVVLNFRKSPKRWGWNDVNCLGPQ-RSVCEMMKIHL
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mouse DCIR1
QWQWVDQTPYEESIT-------FWHNGEPSS-------GNEKCATIIYRWKT-GWGWNDISCSLKQ-KSVCQMKKINL
- mouse DCIR2 QWRWIDQTPYNKSAT-------FWHKGEPNQ-------DWERCVIINHKTT--GWGWNDIPCKDEH-NSVCQVKKIYL
mouse
DCIR3 QWQWIDQTPYDDNTT-------FWHKGEPSS-------DNEQCVIINHRQST-GWGWSDIPCSDKQ-NSICHVKKIYL
mouse
DCIR4 QWQWVDQTPYDQNAT-------SWHSDEPSG-------NTEFCVVLSYHPNVKGWGWSVAPCDGDH-RLICEMRQLYV
mouse DCAR1 QWRWIDQTPYNDRAT-------FWHKGEPNN-------DYEKCVILNYRKT--MWGWNDIDCSDEE-NSVCQMKKIYL- mouse
DCAR2 QWQWVDQTPYEESVT-------FWHNGEPSS-------DNEKCVTVYYRRNI-GWGWNDISCNLKQ-KSVCQMKKINL
- human Dectin-2 NWQWIDKTPYEKNVR-------FWHLGEPNH-------SAEQCASIVFWKPT-GWGWNDVICETRR-NSICEMNKIYL
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mouse Dectin-2 KWQWIDDTPFSQNVR-------FWHPHEPNL-------PEERCVSIVYWNPS-KWGWNDVFCDSKH-NSICEMKKIYL
human BDCA-2 HWQWVDQTPYNENVT-------FWHSGEPNN-------LDERCAIINFRSSE-EWGWNDIHCHVPQ-KSICKMKKIYI
- human MCL QWRWVDQTPFNPRRV-------FWHKNEPDN------SQGENCVVLVYNQD--KWAWNDVPCNFEA-SRICKIPGTTLN
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mouse MCL
QWQWVDKTPFNPHTV-------FWEKGESND------FMEEDCVVLVHVHE--KWVWNDFPCHFEV-RRICKLPGITFNWKPSK
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human Mincle
QWQWVDGTPLTKSLS-------FWDVGEPNN-----IATLEDCATMRDSSNP-RQNWNDVTCFLNY-FRICEMVGINPLNKGKSL
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mouse Mincle
QWQWVDDTPFTESLS-------FWDAGEPNN-----IVLVEDCATIRDSSNS-RKNWNDIPCFYSM-PWICEMPEISPLD
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-
- CONSERVED
CORE RESIDUES Ca
SITE 1 LIGANDS
Ca
SITE 2 LIGANDS (SUGAR-BINDING SITE)
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- Return
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- This page last updated:
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Tuesday, 01 August 2006
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Animal
lectins home
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| Contact information: |
This site is
supported by: |
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- Kurt Drickamer
- Division of Molecular Biosciences
- Faculty of Natural Sciences
- Imperial College London
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- Email:
k.drickamer@imperial.ac.uk
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