Group IV - Selectins

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

If alignments appear scrambled please maximize the width of your browser window.

SIGNAL SEQUENCE and N-TERMINAL REGION

 

L-Selectin               MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRAR-

E-Selectin                               MIASQFLSALTLVLLIK-ESGAWSYNTSTEAMTYDEASA

P-Selectin            MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRK

 

SIGNAL SEQUENCE    

 

 

 

CRD

 

L-Selectin            RFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIW>

E-Selectin            -YCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVW>

P-Selectin            -YCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTW>

 

L-Selectin            TWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALC

E-Selectin            VWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALC

P-Selectin            TWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALC   

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

 

EGF DOMAIN

 

L-Selectin            YTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQ

E-Selectin            YTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCE

P-Selectin            YTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECE

   

CONSERVED RESIDUES

 

 

 

CCP (SUSHI) DOMAINS

           

L-Selectin CCP1       -------FVIQCEPLEAPELGTMDCTHPL-GNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQ-   

L-Selectin CCP2       --------VIQCEPLSAPDLGIMNCSHPL-ASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQ-   

E-Selectin CCP1       -------QIVNCTALESPEHGSLVCSHPL-GNFSYNSSCSISCDRGYLPSSMETMQCMSSGEWSAPIPACN-   

E-Selectin CCP2       --------VVECDAVTNPANGFVECFQNP-GSFPWNTTCTFDCEEGFELMGAQSLQCTSSGNWDNEKPTCK-   

E-Selectin CCP3       --------AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLGPAQ-VECTTQGQWTQQIPVCE-

E-Selectin CCP4       --------AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKRLQCGPTGEWDNEKPTCE-   

E-Selectin CCP5       --------AVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQLECTSQGQWTEEVPSCQV   

E-Selectin CCP6       ---------VKCSSLAVPGKINMSCS----GEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCE-   

P-Selectin CCP1       -------YVRECGELELPQHVLMNCSHPL-GNFSFNSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCL-   

P-Selectin CCP2       --------AAQCPPLKIPERGNMICLHSA-KAFQHQSSCSFSCEEGFALVGPEVVQCTASGVWTAPAPVCK-   

P-Selectin CCP3       --------AVQCQHLEAPSEGTMDCVHPL-TAFAYGSSCKFECQPGYRVRGLDMLRCIDSGHWSAPLPTCE-   

P-Selectin CCP4       --------AISCEPLESPVHGSMDCSPSL-RAFQYDTNCSFRCAEGFMLRGADIVRCDNLGQWTAPAPVCQ-   

P-Selectin CCP5       --------ALQCQDLPVPNEARVNCSHPF-GAFRYQSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQ-   

P-Selectin CCP6       --------AIPCTPLLSPQNGTMTCVQPL-GSSSYKSTCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCE-   

P-Selectin CCP7       --------AIKCPELFAPEQGSLDCSDTR-GEFNVGSTCHFSCNNGFKLEGPNNVECTTSGRWSATPPTCK-   

P-Selectin CCP8       GIASLPTPGLQCPALTTPGQGTMYCRHHP-GTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACR-   

P-Selectin CCP9       --------AVKCSELHVNKPIAMNCSNLW-GNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQ-   

 

CONSERVED RESIDUES

 

 

 

TRANSMEMBRANE REGION and CYTOPLASMIC TAIL

 

L-Selectin            KLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLK-KGKK----SKRSMNDPY------------

E-Selectin            -------APTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLR-KAKKFVPASSCQSLESDGSYQKPSYIL--

P-Selectin            ----AGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP

 

TRANSMEMBRANE REGION

Back to top

_________________________________________________________________________________________________________________________

This page last updated:	Wednesday, 18 October 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk