Group IV - Selectins

Joint human/mouse sequence alignment

Human sequence alignment

Introduction

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SIGNAL SEQUENCE and N-TERMINAL REGION

           

human L-selectin            ---MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRAR-    

mouse L-selectin            ---MVFPWRCEGTYWGSRNILKLWVWTLLCCDFLIHHGTHCWTYHYSEKPMNWENAR-

human E-selectin            -------------------MIASQFLSALTLVLLIK-ESGAWSYNTSTEAMTYDEASA

mouse E-selectin            -------------------MNASRFLSALVFVLLAG-ESTAWYYNASSELMTYDEASA

human P-selectin            MANCQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRK

mouse P-selectin            MAGCPKGSWTPRLRSVILGGAQLIWFSALISELVNQKEVAAWTYNYSTKAYSWNNSRV

 

SIGNAL SEQUENCE    

CRD 

human L-selectin            RFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIW

mouse L-selectin            KFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMW

human E-selectin            -YCQQRYTHLVAIQNKEEIEYLNSILSYSPSYYWIGIRKVNNVW

mouse E-selectin            -YCQRDYTHLVAIQNKEEINYLNSNLKHSPSYYWIGIRKVNNVW

human P-selectin            -YCQNRYTDLVAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTW

mouse P-selectin            -FCRRHFTDLVAIQNKNEIAHLNDVIPFFNSYYWIGIRKINNKW 

 

human L-selectin            TWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALC

mouse L-selectin            TWVGTNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALC

human E-selectin            VWVGTQKPLTEEAKNWAPGEPNNRQKDEDCVEIYIKREKDVGMWNDERCSKKKLALC

mouse E-selectin            IWVGTGKPLTEEAQNWAPGEPNNKQRNEDCVEIYIQRTKDSGMWNDERCNKKKLALC

human P-selectin            TWVGTKKALTNEAENWADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHCLKKKHALC    

mouse P-selectin            TWVGTNKTLTEEAENWADNEPNNKKNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALC

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

EGF DOMAIN

 

human L-selectin            YTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQ

mouse L-selectin            YTASCQPGSCNGRGECVETINNHTCICDAGYYGPQCQ

human E-selectin            YTAACTNTSCSGHGECVETINNYTCKCDPGFSGLKCE

mouse E-selectin            YTASCTNASCSGHGECIETINSYTCKCHPGFLGPNCE

human P-selectin            YTASCQDMSCSKQGECLETIGNYTCSCYPGFYGPECE

mouse P-selectin            YTASCQDMSCSNQGECIETIGSYTCSCYPGFYGPECE 

 

CONSERVED RESIDUES

CCP (SUSHI) DOMAINS

human L-selectin CCP1       -------FVIQCEPLEAPELGTMDCTHPL-GNFSFSSQCAFSCSEGTNLTGIEE-TTCGPFGNWSSPEPTCQ-  

mouse L-selectin CCP1       -------YVVQCEPLEAPELGTMDCIHPL-GNFSFQSKCAFNCSEGRELLGTAE-TQCGASGNWSSPEPICQ-

human L-selectin CCP2       --------VIQCEPLSAPDLGIMNCSHPL-ASFSFTSACTFICSEGTELIGKKK-TICESSGIWSNPSPICQ-  

mouse L-selectin CCP2       --------VVQCEPLEAPELGTMDCIHPL-GNFSFQSKCAFNCSEGRELLGTAE-TQCGASGNWSSPEPICQ-

 

human E-selectin CCP1       -------QIVNCTALESPEHGSLVCSHPL-GNFSYNSSCSISCDRGYLPSSMET-MQCMSSGEWSAPIPACN-  

mouse E-selectin CCP1       -------QAVTCKPQEHPDYGSLNCSHPF-GPFSYNSSCSFGCKRGYLPSSMETTVRCTSSGEWSAPAPACH-

human E-selectin CCP2       --------VVECDAVTNPANGFVECFQNP-GSFPWNTTCTFDCEEGFELMGAQS-LQCTSSGNWDNEKPTCK-

mouse E-selectin CCP2       --------VVECEALTHPAHGIRKCSSNP-GSYPWNTTCTFDCVEGYRRVGAQN-LQCTSSGIWDNETPSCK-

human E-selectin CCP3       --------AVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFMLQGPAQ-VECTTQGQWTQQIPVCE-  

mouse E-selectin CCP3       --------AVTCDAIPQPQNGFVSCSHSTAGELAFKSSCNFTCEQSFTLQGPAQ-VECSAQGQWTPQIPVCK-

human E-selectin CCP4       --------AFQCTALSNPERGYMNCLPSASGSFRYGSSCEFSCEQGFVLKGSKR-LQCGPTGEWDNEKPTCE-  

mouse E-selectin CCP4       --------AVQCEALSAPQQGNMKCLPSASGPFQNGSSCEFSCEEGFELKGSRR-LQCGPRGEWDSKKPTCS-

human E-selectin CCP5       --------AVRCDAVHQPPKGLVRCAHSPIGEFTYKSSCAFSCEEGFELHGSTQ-LECTSQGQWTEEVPSCQV

mouse E-selectin CCP5       --------AVKCDDVPRPQNGVMECAHATTGEFTYKSSCAFQCNEGFSLHGSAQ-LECTSQGKWTQEVPSCQV

human E-selectin CCP6       ---------VKCSSLAVPGKINMSCS----GEPVFGTVCKFACPEGWTLNGSAA-RTCGATGHWSGLLPTCE-

mouse E-selectin CCP6       ---------VQCPSLDVPGKMNMSCS----GTAVFGTVCEFTCPDDWTLNGSAV-LTCGATGRWSGMPPTCE-

 

human P-selectin CCP1       -------YVRECGELELPQHVLMNCSHPL-GNFSFNSQCSFHCTDGYQVNGPSK-LECLASGIWTNKPPQCL-  

mouse P-selectin CCP1       -------YVKECGKVNIPQHVLMNCSHPL-GEFSFNSQCTFSCAEGYELDGPGE-LQCLASGIWTNNPPKCD-

human P-selectin CCP2       --------AAQCPPLKIPERGNMICLHSA-KAFQHQSSCSFSCEEGFALVGPEV-VQCTASGVWTAPAPVCK-  

mouse P-selectin CCP2       --------AVQCQSLEAPPHGTMACMHPI-AAFAYDSSCKFECQPGYRARGSNT-LHCTGSGQWSEPLPTCE-

human P-selectin CCP3       --------AVQCQHLEAPSEGTMDCVHPL-TAFAYGSSCKFECQPGYRVRGLDM-LRCIDSGHWSAPLPTCE- 

mouse P-selectin CCP3       --------AIACEPPEIPIHGSMDCVPST-GTFGYNSSCTFLCAEGFVLKGNDA-IQCADSGQWTAPAPFCE-

human P-selectin CCP4       --------AISCEPLESPVHGSMDCSPSL-RAFQYDTNCSFRCAEGFMLRGADI-VRCDNLGQWTAPAPVCQ- 

mouse P-selectin CCP4       --------ALQCPEFPVPSKAQVNCSDPF-GTLTYQSVCSFSCDEGSLLVGASV-IRCLATGHWNGAPPECQ-

human P-selectin CCP5       --------ALQCQDLPVPNEARVNCSHPF-GAFRYQSVCSFTCNEGLLLVGASV-LQCLATGNWNSVPPECQ- 

mouse P-selectin CCP5       --------AVSCAPMLSPENGSMTCVQPL-GNSTYKSTCQFMCDEGFYLSGPER-LDCSPSGHWTGTPPTCE-

human P-selectin CCP6       --------AIPCTPLLSPQNGTMTCVQPL-GSSSYKSTCQFICDEGYSLSGPER-LDCTRSGRWTDSPPMCE- 

mouse P-selectin CCP6       --------AIKCPGIFAPEQGNLDCSHVH-GEFGVGSICHFSCNEDFELLGSEN-VECTVSGRWSAPPPTCK-

human P-selectin CCP7       --------AIKCPELFAPEQGSLDCSDTR-GEFNVGSTCHFSCNNGFKLEGPNN-VECTTSGRWSATPPTCK- 

mouse P-selectin CCP7       GITSLPAPAVRCPALTTPGQGTMSCQHHL-GSFGPNTTCYFGCKTGFTLRGANS-LRCRASGQWTAVTPMCR-

human P-selectin CCP8       GIASLPTPGLQCPALTTPGQGTMYCRHHP-GTFGFNTTCYFGCNAGFTLIGDST-LSCRPSGQWTAVTPACR- 

mouse P-selectin CCP8       --------AVKCSELHMDTAVAMNCSNPW-GNFSYGSTCTFQCPEGQSLNGSVR-ATCREDGHWSDAMPTCQ-

human P-selectin CCP9       --------AVKCSELHVNKPIAMNCSNLW-GNFSYGSICSFHCLEGQLLNGSAQ-TACQENGHWSTTVPTCQ- 

 

CONSERVED RESIDUES

TRANSMEMBRANE REGION and CYTOPLASMIC TAIL 

human L-selectin            KLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLK-KGKK----SKRSMNDPY

mouse L-selectin            ETNRSFSKIKEGDYNPLFIPVAVMVTAFSGLAFLIWLARRLK-KGKK----SQERMDDPY

human E-selectin            -------APTESNIPLVAGLSAAGLSLLTLAPFLLWLRKCLR-KAKKFVPASSCQSLESDGSYQKPSYIL

mouse E-selectin            -------APVSPTRPLVVALSAAGTSLLTSSSLLYLLMRYFRKKAKKFVPASSCQSLQSFENYHVPSYNV

human P-selectin            ----AGPLTIQEALTYFGGAVASTIGLIMGGTLLALLRKRFRQKDDGKCPLNPHSHLGTYGVFTNAAFDPSP

mouse P-selectin            ----AGTLTIQEALTYLGGAVASTTGLAVGGTLLALLRKRLRKKDDGKCPLNPHSHLGTYGVFTNAAYDPTP 

  

MEMBRANE-SPANNING REGION

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This page last updated:	Wednesday, 18 October 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk