Group V - NK cell receptors
- Human sequence alignment
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Mammalian
proteins containing CTLDs
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If alignments appear scrambled please maximize the width of your browser
window.
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CYTOPLASMIC DOMAIN
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- LDLR
MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWW
- Dectin MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWR
- CLEC1
MQAKYSSTRDMLDDDGDTTMSLHSQASATTRHPEPRRTEHRAPSSTWR
- CLEC2
MQDEDGYITLNIKTRKPALVSVGSASSSWWR
- CLEC1D
MSEEVNYATLTFQDSAGARNNRDGNNLRKRGHPAPSPIWR
- MAFA
MTDSVIYSMLELPTATQAQNDYGPQQKSSSSR
- CD94
MAVFKTTLWR
- Ocil MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWR
- HNKRP1
MD-QQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALK
- KLRF1
MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYK
- MDL-1
MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGT
- AICL
MMTKHKK
- CD69
MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQ
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CLEC2L
MSHTILLIQTTKRPEGRTYADYESVNECMEGVCKMYEEHVKRMNPNSPSIKYDISQLFDFINDLADLSCLWDWRWDGRWDVEPLSLLLDTTTR
- NKG2A
MDNQGVIYSDLNLPPNPKRQQRKPKGNKSSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVG
- NKG2C
MSKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAE
- NKG2E
MNKQRGTFSEVSLAQDPKPQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAE
- NKG2H
MNKQRGTFSEVSLAQDPKPQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAE
- NKG2D
MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCREN-------------
- DCAL1 MVSNFFHVIQVFEKSATLISKTEHIGFVIYSWRKSTTHLGSRRKFAISIYLSEVSLQKYDCPFSGTS
- CD72 MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLR
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- ITIM
LL
YXXL
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TRANSMEMBRANE
DOMAIN and NECK REGION
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- LDLR
CLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSA
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Dectin LIAVILGILCLVILVIAVVLGTMGVLSS
- CLEC1
PVALTLLTLCLVLLIGLAAWGLLFFQYYQLSNTGQDTISQMEERLGNTSQELQSLQVQNIKLAGSLQHVAEKLCRELYNKA-GAHRCS
- CLEC2
VMALILLILYVGMVVGLVALGIWSVMQRNYL-------------------QDENENRTGTLQQLAKRFCQYVVKQSELKGTFKG-HKCS
- CLEC1D
HAALGLVTLCLMLLIGLVTLGMMFLQISNDINSDSEKLSQLQKTIQQQQDNLSQQLGNSNNLSMEEEFLKSQISSLLKRQEQMAIKLCQELIIHTSDHRCN
- MAFA
PSCSCLVAIALGLLTAVLLSVLL-YQWILCQGSNY--------------------------------------------------STCASCP
- CD94
LISGTLGIICLSLMATLGILLKNSFT-----------------------------------KLSIEPAFTPGPNIELQKDSDCC
- Ocil
LFFLIMFLTIIVCGMVAALSAIRA---------------------------------------------------NCHQEPSVCLQA
- HNKRP1
LSCAGIILLVLVVTGLSVSVTSLIQKSSIEK-CSVDIQQSRNKTTERPGLL
- KLRF1
ILLGISGTVNGILTLTLISLILLVL
- AICL
CFIIVGVLITTNIITLIVKLTRDSQS
- CD69
VPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVS
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CLEC2L
LLLGAIAVLLFAILVVMSILASKGCIKCEA
- NKG2A
ILG-IICLI--LMASVVTIVVIPSTLIQRHNNSSLNTRTQK---------ARHCG
- NKG2C VLG-IICIV--LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARHCG
- NKG2E
VLG-IICIV--LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARPCG
- NKG2H
VLG-IICIV--LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARPCG
- NKG2D
ASPFFFCCFIAVAMGIRFII---MVAIWSAVFLNS-LFN-------Q-EVQIPLTES--YCG
- DCAL1 FVVFSLFLICAMAGDVVY
ADIKTVRTSPLELAFPLQRSVSFNFSTVHKS
CD72 YLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQA
- DRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADT
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CTLD
- N-TERMINAL
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- LDLR PCPQDWIWHGENCYLFSS-GSFNWEKSQEKCLSLDAK---LLKINST-ADLDFIQQAI-SYSS-FPFWMGL
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Dectin PCPPNWIIYEKSCYLFSM-SLNSWDGSKRQCWQLGSN---LLKIDSS-NELGFIVKQV-SSQPDNSFWIGL
- CLEC1 PCTEQWKWHGDNCYQFYK-DSKSWEDCKYFCLSENST---MLKINKQ-EDLEFAASQS-YSEFFYSYWTGL
- CLEC2 PCDTNWRYYGDSCYGFFR-HNLTWEESKQYCTDMNAT---LLKIDNR-NIVEYIK-----ARTHLIRWVGL
- CLEC1B2 PCDANWTYYGDSCYGFFK-HNLTWKESEQYCTDMKAT---LLKTDNQ-NILEYIKA-----RTGLIHWVRL
- CLEC1D PCPKMWQWYQNSCYYFTTNEEKTWANSRKDCIDKNST----LVKIDSLEEKDFLM--SQPLLMFSFFWLGL
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MAFA SCPDRWMKYGNHCYYFSV-EEKDWNSSLEFCLARDSH---LLVITDN-QEMSLLQ----VFLSEAFCWIGL
- CD94 SCQEKWVGYRCNCYFISS-EQKTWNESRHLCASQKSS---LLQLQNT-DELDFMS------SSQQFYWIGL
- Ocil
ACPESWIGFQRKCFYFSD-DTKNWTSSQRFCDSQDAD---LAQVESF-QELNFLL----RYKGPSDHWIGL
- HNKRP1 NCPIYWQQLREKCLLFSH-TVNPWNNSLADCSTKESS---LLLIRDK-DELIHTQ--NLIRDKAILFWIGL
- KLRF1 -CQSEWLKYQGKCYWFSN-EMKSWSDSYVYCLERKSH---LLIIHDQ-LEMAFIQ---KNLRQLNYVWIGL
- MDL-1 VCPKDWEFYQARCFFLST-SESSWNESRDFCKGKGST---LAIVNTP-EKLKFLQ----DITDAEKYFIGL
- AICL LCPYDWIGFQNKCYYFSK-EEGDWNSSKYNCSTQHAD---LTIIDNI-EEMNFLR----RYKCSSDHWIGL
- CD69 SCSEDWVGYQRKCYFIST-VKRSWTSAQNACSEHGAT---LAVIDSE-KDMNFLK----RYAGREEHWVGL
- CLEC2L
PCPEDWLLYGRKCYFFSE-EPRDWNTGRQYCHTHEAV---LAVIQSQ-KELEFMF----KFTRR-EPWIGL
- NKG2A HCPEEWITYSNSCYYIGK-ERRTWEESLLACTSKNSS---LLSIDNE-EEMKFLS----IISP--SSWIGV
- NKG2C HCPEEWITYSNSCYYIGK-ERRTWEESLLACTSKNSS---LLSIDNE-EEIKFLA----SILP--SSWIGV
- NKG2D PCPKNWICYKNNCYQFFD-ESKNWYESQASCMSQNAS---LLKVYSK-EDQDLLK----LVKS--YHWMGL
- NKG2E HCPEEWITYSNSCYYIGK-ERRTWEESLQACASKNSSS--LLSIDNE-EEMKFLA----SILP--SSWIGV
- NKG2H HCPEEWITYSNSCYYIGK-ERRTWEESLQACASKNSSS--LLSIDNE-EEMKFLA----SILP--SSWIGV
- DCAL1
CPAKDWKVHKGKCYWIAE-TKKSWNKSQNDCAINNSYLMVIQDITAMVRFNI
- CD72 CCPSGWIMHQKSCFYISL-TSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGL
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- CTLD
- C-TERMINAL
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- LDLR SRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGA----VYAENCILAAFSICQKKANLRAQ
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Dectin SRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSV----IYDQLCSVPSYSICEKKFSM
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CLEC1 LRPDSGKAWLWMDGTPFTSELFHIIIDVT-SPRSRDCVAILNGM----IFSKDCKELKRCVCERRAGMVKPESLHVPPETLGEGD
- CLEC2 SRQKSNEVWKWEDGSVISENMFEFLED---GKGNMNCAYFHNGK----MHPTFCENKHYLMCERKAGMTKVDQLP
- CLEC1B2
SHQNSNEVFFEGIYSTFPIHRFGLSED---GKGNMNCAYFHNQK----RHSTFCENKHYLMCERKAGMAKVDQLP
- CLEC1D
SWDSSGRSWFWEDGSVPSPSLFSTKELDQING-SKGCAYFQKGN----IYISRCSAEIFWICEKTAAPVKTEDLD
- MAFA RNNS---GWRWEDGSPLNFSRISS------NSFVQTCGAINKNG----LQASSCEVPLHWVCKKVRL
- CD94 SYSEEHTAWLWENGSALSQYLFPSFE----TFNTKNCIAYNPNGN---ALDESCEDKNRYICKQQLI
- Ocil SREQ-GQPWKWINGTEWTRQFPIL--------GAGECAYLNDKG----ASSARHYTERKWICSKSDIHV
- HNKRP1 NFSLSEKNWKWINGSFLNSNDLEIRG----DAKENSCISISQTS----VYSEYCSTEIRWICQKELTPVRNKVYPDS
- KLRF1 NFTSLKMTWTWVDGSPIDSKIFFIKG----PAKENSCAAIKESK----IFSETCSSVFKWICQY
- MDL-1 IYHREEKRWRWINNSVFNGNVTNQ-------NQNFNCATIGLTKT---FDAASCDISYRRICEKNAK
- AICL KMAK-NRTGQWVDGATFTKSFGMR--------GSEGCAYLSDDG----AATARCYTERKWICRKRIH
- CD69 KKEP-GHPWKWSNGKEFNNWFNVT--------GSDKCVFLKNTE----VSSMECEKNLYWICNKPYK
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CLEC2L RRVG--DEFHWVNGDPFDPDTFTI-------AGPGECVFVEPTR----LVSTECLMTRPWVCSKMAYT
- NKG2A FRNSSHHPWVTMNGLAFKHEIKDS------DNAELNCAVLQVNR----LKSAQCGSSIIYHCKHKL
- NKG2C FRNSSHHPWVTINGLAFKHKIKDS------DNAELNCAVLQVNR----LKSAQCGSSMIYHCKHKL
- NKG2D VHIPTNGSWQWEDGSILSPNLLTII-----EMQKGDCALYASSFK---GYIENCSTPNTYICMQRTV
- NKG2E FRNSSHHPWVTINGLAFKHEIKDS------DHAERNCAMLHVRG----LISDQCGSSRIIRRGFIMLTRLVLNS
- NKG2H FRNSSHHPWVTINGLAFKHEIKDS------DHAERNCAMLHVRG----LISDQCGSSRIIVSISFRIKALELAVHQIKFYICSNRNDIMIA
- CD72 SSNK---DWKLTDDTQRTRTYAQS----------SKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD
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- CONSERVED
RESIDUES
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__________________________________________________________________________________________________________________
- This page last updated:
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Thursday, 09 March 2006
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Animal
lectins home
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| Contact information: |
This site is
supported by: |
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- Kurt Drickamer
- Division of Molecular Biosciences
- Faculty of Natural Sciences
- Imperial College London
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- Email:
k.drickamer@imperial.ac.uk
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