Group VI - Macrophage Mannose Receptor family

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

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SIGNAL SEQUENCE

 

MMR        MRLPLLLVFASVIPGAVLLLD

Endo180    MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPE

Pla2R      MLLSPSLLLLLLLGGAAGCAEGVAAALTPERLLEWQD

DEC-205    MRTGWATPRRPAGLLMLLFWFFDLAEPSGRAA

 

 

 

CYSTEINE-RICH DOMAIN / R-TYPE CRD (3 LOBES)

 

MMR        TRQFLIYNEDH-KRCVDAVSPS-----AVQTAACNQ-DAESQKFRWVSE

Endo180    PNIFLIFSHGL-QGCLEAQGGQ-----VRVTPACNT-SLPAQRWKWVSR

Pla2R      KGIFVIQSESL-KKCIQAGKSV-----LTLGRTGSKQANKHMLWKWVSN

DEC-205    NDPFTIVHENT-GKCIQPLSDW------VVAQDCSG--TNNMLWKWVSQ

 

MMR        SQIMSVAFKLCLGVPSK--TDWVAITLYACDSK-SEFQKWECKND

Endo180    NRLFNLGTMQCLGTGWPGTNTTASLGMYECDRE-ALNLRWHCRTL

Pla2R      HGLFNIGGSGCLGLNFS--APEQPLSLYECDST-LVSLRWRCNRK

DEC-205    HRLFHLESQKCLGLDIT--KATDNLRMFSCDST--VMLWWKCESL

 

MMR        TLLGIKGE--DLFFNYGNRQEK----NIMLYKGSGLW---SRWKIYGT-TDNLCSRG

Endo180    GDQLSLLL--GARTSNISK-------PGTLERGDQTRS--GQWRIYGS-EEDLCALP

Pla2R      MITGPLQY--SVQVAHDN--------TVVASRKYI-----HKWISYGSGGGDICEYL

DEC-205    YTAAQYRL--ALKDGYAV---------ANTNTS-------DVWKKGGS-EENLCDQP

 

Gal BINDING     GalNAc-SULPHATE BINDING

 

 

 

FIBRONECTIN TYPE II REPEAT

 

MMR        YEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFE

Endo180    YHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKS

Pla2R      HKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAE

DEC-205    YHEIYTRDGNSYGRPCEFPFLIDGTWHHDCIL-DEDHSGPWCATTLNYEYDRKWGICLKPE

 

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LINKER and CTLD - N-TERMINAL PORTION

 

MMR     CTLD1  --------------------GS-E

Endo180 CTLD1  --------------------NDCE

Pla2R   CTLD1  --------------------VGCD

DEC-205 CTLD1  --------------------NGCE

 

MMR     CTLD2  ---GNTTLNSFVIPSESDVPTHCP

Endo180 CTLD2  --KPNATAEPTPPDRWANVKVECE

Pla2R   CTLD2  -YLNHIDHEIVEKDAWKYYATHCE

DEC-205 CTLD2  ----PLNNTVELTDVWTYSDTRCD

 

MMR     CTLD3  -------KSRSQGPEIVEVEKGCR

Endo180 CTLD3  --------AGQLSQGAAEEDHGCR

Pla2R   CTLD3  -----------AGHVLSDAESGCQ

DEC-205 CTLD3  ---------KGEKLNDASSDKMCPPD

 

MMR     CTLD4  ----WAEGVTHPPKPTTTPEPKCP

Endo180 CTLD4  SLGTPVTPELPGPDPTPSLTGSCP

Pla2R   CTLD4  ----PVENQEKAEYEERWPFHPCY

DEC-205 CTLD4  -----MSGPLGPEEASPKPDDPCP

 

MMR     CTLD5  --QKGQTPKPEPTPAPQDNPPVTE

Endo180 CTLD5  --------PRGTDVREPDDSPQGR

Pla2R   CTLD5  ---------PRDVKPKIPFWYQYD

DEC-205 CTLD5  ----PKGRTPKTPDWYNPDRAGIH

 

MMR     CTLD6  --HNSSINATTVMPTMPSVPSGCK

Endo180 CTLD6  ---SNVTKETQPPDLPTTALGGCP

Pla2R   CTLD6  ----KKVWLIEKKKDTPKQHGTCP

DEC-205 CTLD6  ----YNVSSLEKYSPDSAAKVQCS

 

MMR     CTLD7  -----RSDPSLTNPPATIQ

Endo180 CTLD7  GTDPSLSPSPAALPP

Pla2R   CTLD7     ----MQDTSGHGVNTSDMY

DEC-205 CTLD7  --------YSEVKSRQTLQ

DEC-205 CTLD9  --------EMVDYKEEHNT

 

MMR     CTLD8  -------SDEIPATEPPQLPGRCPESDH

Endo180 CTLD8  -------SSGPPPPRRISYHGSCPQGLAD

Pla2R   CTLD8  ----------PPETRQSEHPELCSETS

DEC-205 CTLD8  ------SGNETEKEVKPVDSVKCPSPVLN

DEC-205 CTLD10 -------PTKSKKLSRLTYSSRCPAAKENG

 

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CTLD - MIDDLE PORTION

 

MMR     CTLD1    SLWNKDPLTSVSYQINSKS----ALTWHQARKSCQQQN--AELLSITEIHEQTYLTGLTSRN--------SLTSGLWIGLNSLSFNS

Endo180 CTLD1    TFWDKDQLTDSCYQFNFQS----TLSWREAWASCEQQG--ADLLSITEIHEQTYINGLLTG----------YSSTLWIGLNDLDTSG

Pla2R   CTLD1    TIWEKDLNSHICYQFNLLS----SLSWSEAHSSCQMQG—-GTLLSITDETEENFIREHM----------SSKTVEVWVGLNQLDEDA

DEC-205 CTLD1    DNWEKNEQFGSCYQFNTQT----ALSWKEAYVSCQNQG--ADLLSINSAAELTYLKDKE-G----------IAKIFWIGLNQLYSAR

 

MMR     CTLD2    SQWW--PYAGHCYKIHRDE----KKIQRDALTTCRKEG--GDLTSIHTIEELDFIISQLGLE---------PNDELWIGLNDIKIQM

Endo180 CTLD2    PSWQ--PFQGHCYRLQAE-----KRSWQESKKACLRGG--GDLVSIHSMAELEFITKQIKQE---------V-EELWIGLNDLKLQM

Pla2R   CTLD2    PGWN--PYNRNCYKLQKE-----EKTWHEALRSCQADN--SALIDITSLAEVEFLVTLLGDE---------NASETWIGLSSNKIPV

DEC-205 CTLD2    AGWL--PNNGFCYLLVNE-----SNSWDKAHAKCKAFS--SDLISIHSLADVEVVVTKLHNE--------DIKEEVWIGLKNINIPT

 

MMR     CTLD3    KGWK--KHHFYCYMIGHT-----LSTFAEANQTCNNEN--AYLTTIEDRYEQAFLTSFVGASG-------RPEKYFWTGLSDIQTKG

Endo180 CTLD3    KGWT--WHSPSCYWLGED-----QVTYSEARRLCTDHG--SQLVTITNRFEQAFVSSLIYN---------WEGEYFWTALQDLNSTG

Pla2R   CTLD3    EGWE--ETCGFCYKIDTVLR---SFDQASSGYYCP-----PALVTITNRFEQAFITSLISSVVK------MKDSYFWIALQDQNDTG

DEC-205 CTLD3    EGWK--RHGETCYKIYED-----EVPFG---TNCN--------LTITSRFEQEYLNDLMKKYDK------SLRKYFWTGLRDVDSCG

 

MMR     CTLD4    EDWGASSRTSLCFKLYAKGKH-EKKTWFESRDFCRALG--GDLASINNKEEQQTIWRLITS----------YHKLFWLGLTYGSPSE

Endo180 CTLD4    QGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELG--AQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRG

Pla2R   CTLD4    LDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFG--AHLASFAHIEEENFVNELLHPKFN-----WTEERQFWIGFNKRNPLN

DEC-205 CTLD4    EGWQSFPASLSCYKVFHAERIVRKRNWEEAERFCQALG--AHLSSFSHVDEIKEFLHFLTDQFS-------GQHWLWIGLNKRSPDL

 

MMR     CTLD5    DGWV--IYKDYQYYFSKE-----KETMDNARAFCKRNF--GDLVSIQSESEKKFLWKYVND----------AQSAYFIGLLISLDK-

Endo180 CTLD5    REWLR--FQEAEYKFFEH-----HSTWAQAQRICTWFQ--AELTSVHSQAELDFLSHNLQKFSR------AQEQHWWIGLHTSESDG

Pla2R   CTLD5    VPWL--FYQDAEYLFHTF-----ASEWLNFEFVCSWLH--SDLLTIHSAHEQEFIHSKIKALS-------KYGASWWIGLQEERAND

DEC-205 CTLD5    GPPL--IIEGSEYWFVADL----HLNYEEAVLYCASNH--SFLATITSFVGLKAIKNKIANIS-------GDGQKWWIRIS------

 

MMR     CTLD6    EGWN--FYSNKCFKIFGFMEE-ERKNWQEARKACIGFG--GNLVSIQNEKEQAFLTYHMKPLD--------STFSAWTGLNDVNSEH

Endo180 CTLD6    SDWI--QFLNKCFQVQGQEPQ-SRVKWSEAQFSCEQQE--AQLVTITNPLEQAFITASLPN----------VTFDLWIGLHASQR--

Pla2R   CTLD6    KGWL--YFNYKCLLLNIPKDPSSWKNWTHAQHFCAEEG--GTLVAIESEVEQAFITMNLFG----------QTTSVWIGLQNDDY--

DEC-205 CTLD6    EQWI--PFQNKCFLKIKP----VSLTFSQASDTCHSYG--GTLPSVLSQIEQDFITSLLPD----------MEATLWIGLRWTAYEK

 

MMR     CTLD7    TDGFV-KYGKSSYSLMRQ-----KFQWHEAETYCKLHN--SLIASILDPYSNAFAWLQMEYT---------SNERVWIALNSNLTDN

Endo180 CTLD7    APGTELSYLNGTFRLLQK-----PLRWHDALLLCESHN--ASLAYVPDPYTQAFLTQAARG----------LRTPLWIGLAGEEGSR

Pla2R   CTLD7    PMPNTLEYGNRTYKIINA-----NMTWYAAIKTCLMHK--AQLVSITDQYHQSFLTVVLNR----------LGYAHWIGLFTTDNGL

DEC-205 CTLD7    NASETVKYLNNLYKIIPK-----TLTWHSAKRECLKSN--MQLVSITDPYQQAFLSVQALL----------HNSSLWIGLFSQDDEL

DEC-205 CTLD9    TLPQFMPYEDGIYSVIQK-----KVTWYEALNMCSQSG--GHLASVHNQNGQLFLEDIVKR----------DGFPLWVGLSSHDGSE

 

MMR     CTLD8    TAWI--PFMGHCYYIESS----YTRNWGQASLECLRMG--SSLVSIESAAESSFLSYRVEK----------SKTNFWIGLFRNVEG-

Endo180 CTLD8    SAWI--PFREHCYSFHMEL----LLGHKEARQRCQRAG--GAVLSILDEMENVFVWEHLQSYE-------GQSRGAWLGMNFNPKGG

Pla2R   CTLD8    IPWI--KFKSNCYKFSTVLD---SMSFEAAHEFCKKEG--SNLLTIKDEAENAFLLEELFAFG-------SSVQMVWLNAQFDGNNE

DEC-205 CTLD8    TPWI--PFQNCCYNFIITKNRHMATTQDEVHTKCQKLNPKSHILSIRDEKENNFVLEQLLYF---------NYMASWVMLGITYRNK

DEC-205 CTLD10   SRWI--QYKGHCYKSDQA-----LHSFSEAKKLCSKHDHSATIVSIKDEDENKFVSRLMRENN-------NITMRVWLGLSQHSVDQ

 

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CTLD - C-TERMINAL PORTION

 

MMR     CTLD1    --GWQWSDR----SPFRYL--NWLP--GSPSAE-----------PGKSCVSLNPGKN--------------AKWENLECVQKLG-YICKK

Endo180 CTLD1    --GWQWSDN----SPLKYL--NWES--DQPDNP-----------SEENCGVIRTESS--------------GGWQNRDCSIALP-YVCKK

Pla2R   CTLD1    --GWQWSDG----TPLNYL--NWSP---EVNFEPF---------VEDHCGTPSSFMP--------------SAWNSRDCESTLP-YICKK

DEC-205 CTLD1    --GWEWSDH----KPLNFL--NWDP--DRPSAPTI---------GGSSCARMDAES---------------GLWQSFSCEAQLP-YVCRK

 

MMR     CTLD2    --YFEWSDG----TPVTFT--KWLR--GEPSHENN---------RQEDCVVMKGKD---------------GYWADRGCEWPLG-YICKM

Endo180 CTLD2    --NFEWSDG----SLVSFT--HWHP--FEPNNFRD---------SLEDCVTIWGPE---------------GRWNDSPCNQSLP-SICKK

Pla2R   CTLD2    --SFEWSND----SSVIFT--NWHT--LEPHIFPN---------RSQLCVSAEQSE---------------GHWKVKNCEERLF-YICKK

DEC-205 CTLD2    --LFQWSDG----TEVTLT--YWDE--NEPNVPYN---------KTPNCVSYLGEL---------------GQWKVQSCEELK--YVCKR

 

MMR     CTLD3    --TFQWTIE----EEVRFT--HWNS--DMPGRK-------------PGCVAMRTGIAG-------------GLWDVLKCDEKAK-FVCKH

Endo180 CTLD3    --SFFWLSG----DEVMYT--HWNR--DQPGYS------------RGGCVALATGSAM-------------GLWEVKNCTSFRARYICRQ

Pla2R   CTLD3    --EYTWKPVGQKPEPVQYT--HWNT--HQPRYS-------------GGCVAMRGRHPL-------------GRWEVKHCRHFKAMSLCKQ

DEC-205 CTLD3    --EYNWATVGGRRRAVTFS--NWNF--LEPASP-------------GGCVAMSTGKSV-------------GKWEVKDCRSFKALSICKK

 

MMR     CTLD4    --GFTWSDG----SPVSYE--NWAY--GEPNNYQ----------NVEYCGELKGDPT--------------MSWNDINCEHLNN-WICQI

Endo180 CTLD4    GQSWRWSDG----VGFSYH--NFDR--SRHDDD-----------DIRGCAVLDLAS---------------LQWVAMQCDTQLD-WICKI

Pla2R   CTLD4    AGSWEWSDR----TPVVSS--FLDN--TYFGED------------ARNCAVYKPN----------------KTLLPLHCGSKRE-WICKI

DEC-205 CTLD4    QGSWQWSDR----TPVSTI--IMPN-EFQQDYD------------IRDCAAVKVFHRPWRRGWHFYDDREFIYLRPFACDTKLE-WVCQI

 

MMR     CTLD5    --KFAWMDG----SKVDYV--SWAT--GEPNFAN----------EDENCVTMYSNS---------------GFWNDINCGYPNA-FICQR

Endo180 CTLD5    --RFRWTDG----SIINFI--SWAP--GKPRPVG----------KDKKCVYMTASR---------------EDWGDQRCLTALP-YICKR

Pla2R   CTLD5    --EFRWRDG----TPVIYQ--NWDT--GRERTVNN---------QSQRCGFISSIT---------------GLWGSEECSVSMP-SICKR

DEC-205 CTLD5    ----EWPID----DHFTYSRYPWHR---FPVTF------------GEECLYMSAKTWLI------------DLGKPTDCSTKLP-FICEK

 

MMR     CTLD6    --TFLWTDG----RGVHYT--NWGK--GYPGGRRSS---LSY--EDADCVVIIGGASNEA-----------GKWMDDTCDSKRG-YICQT

Endo180 CTLD6    --DFQWVEQ----EPLMYA--NWAP--GEPSGPSPA---PSGN-KPTSCAVVLHSPSAHFT----------GRWDDRSCTEETHGFICQK

Pla2R   CTLD6    ---ETWLNG----KPVVYS--NWSP--FDIINIPSHNTTEVQK-HIPLCALLSSNPNFHFT----------GKWYFEDCGKEGYGFVCEK

DEC-205 CTLD6    --INKWTDN----RELTYS--NFHP--LLVSGRLRIPENFFEEESRYHCALILNLQKSPFT----------GTWNFTSCSERHFVSLCQK

 

MMR     CTLD7    --QYTWTDK----WRVRYT--NWAA--DEPKLK-------------SACVYLDLD----------------GYWKTAHCNESFY-FLCKR

Endo180 CTLD7    --RYSWVSE----EPLNYV--GWQD--GEPQQP-------------GGCTYVDVD----------------GAWRTTSCDTKLQGAVCGV

Pla2R   CTLD7    --NFDWSDG----TKSSFT--FWKD----EESS-----------LLGDCVFADSN----------------GRWHSTACDSFLQGAICHV

DEC-205 CTLD7    --NFGWSDG----KRLHFS--RWA-----ETNG-----------QLEDCVVLDTD----------------GFWKTVDCNDNQPGAICYY

DEC-205 CTLD9    -SSFEWSDG----STFDYI--PWKG----QTSP-------------GNCVLLDPK----------------GTWKHEKCNSVKDGAICYK

 

MMR     CTLD8    --TWLWINN----SPVSFV--NWNT--GDPSGE------------RNDCVALHASS---------------GFWSNIHCSSYKG-YICKR

Endo180 CTLD8    --TLVWQDN----TAVNYS--NWGPPGLGPSMLS-----------HNSCYWIQSNS---------------GLWRPGACTNITMGVVCKL

Pla2R   CTLD8    --TIKWFDG----TPTDQS--NWGIR--KPDTDYF---------KPHHCVALRIPE---------------GLWQLSPCQEKKG-FICKM

DEC-205 CTLD8    --SLMWFDK----TPLSYT--HWRA--GRPTIK-----------NEKFLAGLSTD------GFWDIQT--FKVIEEAVYFHQHSILACKI

DEC-205 CTLD10   --SWSWLDG----SEVTFV--KWEN---KSKSG------------VGRCSMLIASN---------------ETWKKVECEHGFGRVVCKV

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

 

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TRANSMEMBRANE REGION and CYTOPLASMIC TAIL

 

human MMR      PKIIDAKPTHELLTTKADTRKMDPSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSDMKDLVGNIEQNEHSVI

human Endo180               PRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE

human Pla2R                EADIHTAEALPEKGPSHSIIPLAVVLTLIVIVAICTLSFCIYKHNGGFFRRLAGFRNPYYPATNFSTVYLEENILISDLEKSDQ 

human DEC-205                          PLGPDYTAIAIIVATLSILVLMGGLIWFLFQRHRLHLAGFSSVRYAQGVNEDEIMLPSFHD

 

TRANSMEMBRANE REGION

 

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This page last updated:	Thursday, 09 March 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk