Group VI - Macrophage Mannose Receptor family

Joint human/mouse sequence alignment

Human sequence alignment

Introduction

If alignments appear scrambled please maximize the width of your browser window.

 

 

SIGNAL SEQUENCE

 

human MMR        MRLPLLLVFASVIPGAVLLLD

mouse MMR        MRLLLLLAFISVIPVSVQLLD

human Endo180    MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPE

mouse Endo180    MVPIRPALAPWPRHLLRCVLLLGGLRLGHP-ADSAAALLE

human Pla2R      MLLSPSLLLLLLLGGAAGCAEGVAAALTPERLLEWQD

mouse Pla2R      MVQWLAMLQLLWLQQLLLLGIHQGIAQDLTHIQEPSLEWRD

human DEC-205    MRTGWATPRRPAGLLMLLFWFFDLAEPSGRAA

mouse DEC-205    MRTGRVTPGLAAGLLLLLLRSFGLVEPSESSG

CYSTEINE-RICH DOMAIN / R-TYPE CRD (3 LOBES)

 

human MMR        TRQFLIYNEDH-KRCVDAVSPS-----AVQTAACNQ-DAESQKFRWVSE

mouse MMR        ARQFLIYNEDH-KRCVDALSAI-----SVQTATCNP-EAESQKFRWVSD

human Endo180    PNIFLIFSHGL-QGCLEAQGGQ-----VRVTPACNT-SLPAQRWKWVSR

mouse Endo180    PDVFLIFSQGM-QGCLEAQGVQ-----VRVTPFCNA-SLPAQRWKWVSR

human Pla2R      KGIFVIQSESL-KKCIQAGKSV-----LTLGRTGSKQANKHMLWKWVSN

mouse Pla2R      KGIFIIQSESL-KTCIQAGKSV-----LTL-ENCK-QPNEHMLWKWVSD

human DEC-205    NDPFTIVHENT-GKCIQPLSDW------VVAQDCSG--TNNMLWKWVSQ

mouse DEC-205    NDPFTIVHENT-GKCIQPLSDW------VVAQDCSG--TNNMLWKWVSQ

 

 

human MMR        SQIMSVAFKLCLGVPSK--TDWVAITLYACDSK-SEFQKWECKND

mouse MMR        SQIMSVAFKLCLGVPSK--TDWASVTLYACDSK-SEYQKWECKND

human Endo180    NRLFNLGTMQCLGTGWPGTNTTASLGMYECDRE-ALNLRWHCRTL

mouse Endo180    NRLFNLGATQCLGTGWPVTNTTVSLGMYECDREALSLRMAVSYTR

human Pla2R      HGLFNIGGSGCLGLNFS--APEQPLSLYECDST-LVSLRWRCNRK

mouse Pla2R      DHLFNVGGSGCLGLNIS--ALEQPLKLYECDST-LISLRWHCDRK

human DEC-205    HRLFHLESQKCLGLDIT--KATDNLRMFSCDST--VMLWWKCESL

mouse DEC-205    HRLFHLESQKCLGLDIT--KATDNLRMFSCDST--VMLWWKCEHHSL

 

human MMR        TLLGIKGE--DLFFNYGNRQEK----NIMLYKGSGLW---SRWKIYGT-TDNLCSRG

mouse MMR        TLFGIKGT--ELYFNYGNRQEK----NIKLYKGSGLW---SRWKVYGT-TDDLCSRG

human Endo180    GDQLSLLL--GARTSNISK-------PGTLERGDQTRS--GQWRIYGS-EEDLCALP

mouse Endo180    GPVVPASG--GSCKQCIQA-----------WHLERGDQTRSGHWNIYGSEEDLCARP

human Pla2R      MITGPLQY--SVQVAHDN--------TVVASRKYI-----HKWISYGSGGGDICEYL

mouse Pla2R      MIEGPLQY--KVQVKSDN--------TVVA-RKQI-----HRWIAYTSSGGDICEHP

human DEC-205    YTAAQYRL--ALKDGYAV---------ANTNTS-------DVWKKGGS-EENLCDQP

mouse DEC-205    YTAAQYRL--ALKDGYAV---------ANTNTS-------DVWKKGGS-EENLCAQP

 

Gal BINDING     GalNAc-SULPHATE BINDING

 

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FIBRONECTIN TYPE II REPEAT

 

human MMR        YEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFE

mouse MMR        YEAMYSLLGNANGAVCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDKDKLFGFCPLHFE

human Endo180    YHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKS

mouse Endo180    YYEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKS

human Pla2R      HKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSAE

mouse Pla2R      SRDLYTLKGNAHGMPCVFPFQFKGHWHHDCIREGQKEHLLWCATTSRYEEDEKWGFCPDPTSMK

human DEC-205    YHEIYTRDGNSYGRPCEFPFLIDGTWHHDCIL-DEDHSGPWCATTLNYEYDRKWGICLKPE

mouse DEC-205    YHEIYTRDGNSYGRPCEFPFLIGETWYHDCIH-DEDHSGPWCATTLSYEYDQKWGICLLPE

 

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LINKER and CTLD - N-TERMINAL PORTION

 

human MMR     CTLD1      --------------------GS-E

mouse MMR     CTLD1      --------------------GS-E

human Endo180 CTLD1      --------------------NDCE

mouse Endo180 CTLD1      --------------------NDCE

human Pla2R   CTLD1      --------------------VGCD

mouse Pla2R   CTLD1      --------------------VFCD

human DEC-205 CTLD1      --------------------NGCE

mouse DEC-205 CTLD1      --------------------SGCE

 

human MMR     CTLD2      ---GNTTLNSFVIPSESDVPTHCP

mouse MMR     CTLD2      ---GNNTLNPFIIPSASDVPTGCP

human Endo180 CTLD2      --KPNATAEPTPPDRWANVKVECE

mouse Endo180 CTLD2      --KPNATVEPIQPDRWTNVKVECD

human Pla2R   CTLD2      -YLNHIDHEIVEKDAWKYYATHCE

mouse Pla2R   CTLD2      -DLNHTAQGILEKDSWKYHATHCD

human DEC-205 CTLD2      ----PLNNTVELTDVWTYSDTRCD

mouse DEC-205 CTLD2      ----PLNNTLELPDVWTYTDTHCH

 

human MMR     CTLD3      -------KSRSQGPEIVEVEKGCR

mouse MMR     CTLD3      -------VSQSHAVVPEGADKGCR

human Endo180 CTLD3      --------AGQLSQGAAEEDHGCR

mouse Endo180 CTLD3      --------AGRLSQGAAEEDHDCR

human Pla2R   CTLD3      -----------AGHVLSDAESGCQ

mouse Pla2R   CTLD3      -----------AGQVPADEQSGCP

human DEC-205 CTLD3      ---------KGEKLNDASSDKMCPPD

mouse DEC-205 CTLD3      ---------KGEITKDAESDKLCPPD 

 

human MMR     CTLD4      ----WAEGVTHPPKPTTTPEPKCP

mouse MMR     CTLD4      ----WAEGVTRPPEPTTTPEPKCP

human Endo180 CTLD4      SLGTPVTPELPGPDPTPSLTGSCP

mouse Endo180 CTLD4      SLGTPVTPELPGPDPTPSLTGSCP

human Pla2R   CTLD4      ----PVENQEKAEYEERWPFHPCY

mouse Pla2R   CTLD4      ----PVKIWEKTELEERWPFHPCY

human DEC-205 CTLD4      -----MSGPLGPEEASPKPDDPCP

mouse DEC-205 CTLD4      -----VSEPQEPEEAAPKPDDPCP 

 

human MMR     CTLD5      --QKGQTPKPEPTPAPQDNPPVTE

mouse MMR     CTLD5      ---KGKTLLPEPTPAPQDNPPVTA

human Endo180 CTLD5      --------PRGTDVREPDDSPQGR

mouse Endo180 CTLD5      --------PRGVDVREPDIGRQGR

human Pla2R   CTLD5      ---------PRDVKPKIPFWYQYD

mouse Pla2R   CTLD5      ---------PRDVRPKFPDWYQYD

human DEC-205 CTLD5      ----PKGRTPKTPDWYNPDRAGIH

mouse DEC-205 CTLD5      ----PKGSTPQMPDWYNPERTGIH 

 

human MMR     CTLD6      --HNSSINATTVMPTMPSVPSGCK

mouse MMR     CTLD6      --HNSSINAT-AMPTTPTTPGGCK

human Endo180 CTLD6      ---SNVTKETQPPDLPTTALGGCP

mouse Endo180 CTLD6      ---SNSSGETQPQDLPPSALGGCP

human Pla2R   CTLD6      ----KKVWLIEKKKDTPKQHGTCP

mouse Pla2R   CTLD6      ----VKIWVIEKEK-PPTQPGTCP

human DEC-205 CTLD6      ----YNVSSLEKYSPDSAAKVQCS

mouse DEC-205 CTLD6      ----YNVSSLEKYSPDPAAKVQCT

 

human MMR     CTLD7      -----RSDPSLTNPPATIQ

mouse MMR     CTLD7      -----QTDPSLPVSPTTTP

human Endo180 CTLD7      GTDPSLSPSPAALPP

mouse Endo180 CTLD7      GTDPSLSPSPAATPP

human Pla2R   CTLD7      ----MQDTSGHGVNTSDMY

mouse Pla2R   CTLD7      ----MQDTLEHHVNVSDTS

human DEC-205 CTLD7      --------YSEVKSRQTLQ

mouse DEC-205 CTLD7      --------YSETEDGQPWE 

human DEC-205 CTLD9      --------EMVDYKEEHNT

mouse DEC-205 CTLD9      --------EMVDYEDKHNG 

 

human MMR     CTLD8      -------SDEIPATEPPQLPGRCPESDH

mouse MMR     CTLD8      -------SDEIPATEPPQLPGKCPESEQ

human Endo180 CTLD8      -------SSGPPPPRRISYHGSCPQGLAD

mouse Endo180 CTLD8      -------SRGPPP-RRINYRGSCPQGLAD

human Pla2R   CTLD8      ----------PPETRQSEHPELCSETS

mouse Pla2R   CTLD8      ----------VTETKAFEHPGLCSETS

human DEC-205 CTLD8      ------SGNETEKEVKPVDSVKCPSPVLN

mouse DEC-205 CTLD8      ------PGNETEEEVRALDTAKCPSPVQS 

human DEC-205 CTLD10     -------PTKSKKLSRLTYSSRCPAAKENG

mouse DEC-205 CTLD10     -------PTKDKKLIFHVKSSKCPVAKRDG

 

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CTLD - MIDDLE PORTION

 

human MMR     CTLD1      SLWNKDPLTSVSYQINSKS----ALTWHQARKSCQQQN--AELLSITEIHEQTYLTGLTSRN--------SLTSGLWIGLNSLSFNS

mouse MMR     CTLD1      RLWNKDPLTGILYQINSKS----ALTWHQARASCKQQN--ADLLSVTEIHEQMYLTGLTS----------SLSSGLWIGLNSLSVRS

human Endo180 CTLD1      TFWDKDQLTDSCYQFNFQS----TLSWREAWASCEQQG--ADLLSITEIHEQTYINGLLTG----------YSSTLWIGLNDLDTSG

mouse Endo180 CTLD1      TFWDKDQLTDSCYQFNFQS----TLSWREAWASCEQQG--ADLLSITEIHEQTYINGLLTG----------YSSTLWIGLNDLDTSG

human Pla2R   CTLD1      TIWEKDLNSHICYQFNLLS----SLSWSEAHSSCQMQG—-GTLLSITDETEENFIREHM----------SSKTVEVWVGLNQLDEDA

mouse Pla2R   CTLD1      ATWQRNGSSRICYQFNLLS----SLSWNQAHSSCLMQG--GALLSIADEDEEDFIRKHL----------SKVVKEVWIGLNQLDEKA

human DEC-205 CTLD1      DNWEKNEQFGSCYQFNTQT----ALSWKEAYVSCQNQG--ADLLSINSAAELTYLKDKE-G----------IAKIFWIGLNQLYSAR

mouse DEC-205 CTLD1      GNWEKNEQIGSCYQFNNQE----ILSWKEAYVSCQNQG--ADLLSIHSAAELAYITGKE-----------DIARLVWLGLNQLYSAR

 

human MMR     CTLD2      SQWW--PYAGHCYKIHRDE----KKIQRDALTTCRKEG--GDLTSIHTIEELDFIISQLGLE---------PNDELWIGLNDIKIQM

mouse MMR     CTLD2      NQWW--PYAGHCYRIHREE----KKIQKYALQACRKEG—GDLASIHSIEEFDFIFSQLGYE----------PNDELWIGLNDIKIQM

human Endo180 CTLD2      PSWQ--PFQGHCYRLQAE-----KRSWQESKKACLRGG--GDLVSIHSMAELEFITKQIKQE---------V-EELWIGLNDLKLQM

mouse Endo180 CTLD2      PSWQ--PFQGHCYRLQAE-----KRSWQESKRACLRGG--GDLLSIHSMAELEFITKQIKQE---------V-EELWIGLNDLKLQM

human Pla2R   CTLD2      PGWN--PYNRNCYKLQKE-----EKTWHEALRSCQADN--SALIDITSLAEVEFLVTLLGDE---------NASETWIGLSSNKIPV

mouse Pla2R   CTLD2      PDWT--PFNRKCYKLKKD-----RKSWLGALHSCQSND--SVLMDVASLAEVEFLVSLLRDE---------NASETWIGLSSNKIPV

human DEC-205 CTLD2      AGWL--PNNGFCYLLVNE-----SNSWDKAHAKCKAFS--SDLISIHSLADVEVVVTKLHNE--------DIKEEVWIGLKNINIPT

mouse DEC-205 CTLD2      VGWL--PNNGFCYLLANE-----SSSWDAAHLKCKAFG--ADLISMHSLADVEVVVTKLHNG--------DVKKEIWTGLKNTNSPA

 

human MMR     CTLD3      KGWK--KHHFYCYMIGHT-----LSTFAEANQTCNNEN--AYLTTIEDRYEQAFLTSFVGASG-------RPEKYFWTGLSDIQTKG

mouse MMR     CTLD3      KGWK--RHGFYCYLIGST-----LSTFTDANHTCTNEK--AYLTTVEDRYEQAFLTSLVG---------LRPEKYFWTGLSDVQNKG

human Endo180 CTLD3      KGWT--WHSPSCYWLGED-----QVTYSEARRLCTDHG--SQLVTITNRFEQAFVSSLIYN---------WEGEYFWTALQDLNSTG

mouse Endo180 CTLD3      KGWT--WHSPSCYWLGED-----QVIYSDARRLCTDHG--SQLVTITNRFEQAFVSSLIYN---------WEGEYFWTALQDLNSTG

human Pla2R   CTLD3      EGWE--ETCGFCYKIDTVLR---SFDQASSGYYCP-----PALVTITNRFEQAFITSLISSVVK------MKDSYFWIALQDQNDTG

mouse Pla2R   CTLD3      AGWE--RHGRFCYKIDTVLR---SFEEASSGYYCS-----PALLTITSRFEQAFITSLISSVAE-------KDSYFWIALQDQNNTG

human DEC-205 CTLD3      EGWK--RHGETCYKIYED-----EVPFG---TNCN--------LTITSRFEQEYLNDLMKKYDK------SLRKYFWTGLRDVDSCG

mouse DEC-205 CTLD3      EGWK--RHGETCYKIYEK-----EAPFG---TNCN--------LTITSRFEQEFLNYMMKNYDK------SLRKYFWTGLRDPDSRG

 

human MMR     CTLD4      EDWGASSRTSLCFKLYAKGKH-EKKTWFESRDFCRALG--GDLASINNKEEQQTIWRLITS----------YHKLFWLGLTYGSPSE

mouse MMR     CTLD4      ENWGTTSKTSMCFKLYAKGKH-EKKTWFESRDFCKAIG--GELASIKSKDEQQVIWRLITSSG-------SYHELFWLGLTYGSPSE

human Endo180 CTLD4      QGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELG--AQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRG

mouse Endo180 CTLD4      QGWVSDPKLRHCYKVFSSERLQEKKSWIQALGVCRELG--AQLLSLASYEEEHFVAHMLNKIFGESEPESHEQHWFWIGLNRRDPRE

human Pla2R   CTLD4      LDWESEPGLASCFKVFHSEKVLMKRTWREAEAFCEEFG--AHLASFAHIEEENFVNELLHPKFN-----WTEERQFWIGFNKRNPLN

mouse Pla2R   CTLD4      MDWESATGLASCFKVFHSEKVLMKRSWREAEAFCEEFG--AHLASFAHIEEENFVNELLHSKFN-----WTQERQFWIGFNRRNPLN

human DEC-205 CTLD4      EGWQSFPASLSCYKVFHAERIVRKRNWEEAERFCQALG--AHLSSFSHVDEIKEFLHFLTDQFS-------GQHWLWIGLNKRSPDL

mouse DEC-205 CTLD4      EGWHTFPSSLSCYKVFHIERIVRKRNWEEAERFCQALG--AHLPSFSRREEIKDFVHLLKDQFS-------GQRWLWIGLNKRSPDL

 

human MMR     CTLD5      DGWV--IYKDYQYYFSKE-----KETMDNARAFCKRNF--GDLVSIQSESEKKFLWKYVND----------AQSAYFIGLLISLDK-

mouse MMR     CTLD5      DGWV--IYKDYQYYFSKE-----KETMDNARRFCKKNF--GDLATIKSESEKKFLWKYINKNG--------GQSPYFIGMLISMDK-

human Endo180 CTLD5      REWLR--FQEAEYKFFEH-----HSTWAQAQRICTWFQ--AELTSVHSQAELDFLSHNLQKFSR------AQEQHWWIGLHTSESDG

mouse Endo180 CTLD5      LEWVR--FQEAEYKFFEH-----HSSWAQAQRICTWFQ--ADLTSVHSQAELGFLGQNLQKLSS------DQEQHWWIGLHTLESDG

human Pla2R   CTLD5      VPWL--FYQDAEYLFHTF-----ASEWLNFEFVCSWLH--SDLLTIHSAHEQEFIHSKIKALS-------KYGASWWIGLQEERAND

mouse Pla2R   CTLD5      APWL--FYQNAEYLFHTH-----PAEWATFEFVCGWLR--SDFLTIYSAQEQEFIHSKIKGLT-------KYGVKWWIGLEEGGARD

human DEC-205 CTLD5      GPPL--IIEGSEYWFVADL----HLNYEEAVLYCASNH--SFLATITSFVGLKAIKNKIANIS-------GDGQKWWIRIS------

mouse DEC-205 CTLD5      GPPV--IIEGSEYWFVADP----HLNYEEAVLYCASNH--SFLATITSFTGLKAIKNKLANIS-------GEEQKWWVKTS------

 

human MMR     CTLD6      EGWN--FYSNKCFKIFGFMEE-ERKNWQEARKACIGFG--GNLVSIQNEKEQAFLTYHMKPLD--------STFSAWTGLNDVNSEH

mouse MMR     CTLD6      EGWH--LYKNKCFKIFGFANE-EKKSWQDARQACKGLK--GNLVSIENAQEQAFVTYHMRD----------STFNAWTGLNDINAEH

human Endo180 CTLD6      SDWI--QFLNKCFQVQGQEPQ-SRVKWSEAQFSCEQQE--AQLVTITNPLEQAFITASLPN----------VTFDLWIGLHASQR--

mouse Endo180 CTLD6      SGWN--QFLNKCFRIQGQDPQ-DRVKWSEAQFSCEQQE--AQLVTIANPLEQAFITASLPN----------VTFDLWIGLHASQR--

human Pla2R   CTLD6      KGWL--YFNYKCLLLNIPKDPSSWKNWTHAQHFCAEEG--GTLVAIESEVEQAFITMNLFG----------QTTSVWIGLQNDDY--

mouse Pla2R   CTLD6      KGWL--YFNYKCFLVTIPKDPRELKTWTGAQEFCVAKG--GTLVSIKSELEQAFITMNLFG----------QTTNVWIGLQSTNH--

human DEC-205 CTLD6      EQWI--PFQNKCFLKIKP----VSLTFSQASDTCHSYG--GTLPSVLSQIEQDFITSLLPD----------MEATLWIGLRWTAYEK

mouse DEC-205 CTLD6      EKWI--PFQNKCFLKVNS----GPVTFSQASGICHSYG--GTLPSVLSRGEQDFIISLLPE----------MEASLWIGLRWTAYER

 

human MMR     CTLD7      TDGFV-KYGKSSYSLMRQ-----KFQWHEAETYCKLHN--SLIASILDPYSNAFAWLQMEYT---------SNERVWIALNSNLTDN

mouse MMR     CTLD7      KDGFV-TYGKSSYSLMKL-----KLPWHEAETYCKDHT--SLLASILDPYSNAFAWMKMHPF----------NVPIWIALNSNLTNN

human Endo180 CTLD7      APGTELSYLNGTFRLLQK-----PLRWHDALLLCESHN--ASLAYVPDPYTQAFLTQAARG----------LRTPLWIGLAGEEGSR

mouse Endo180 CTLD7      APGAELSYLNHTFRLLQK-----PLRWKDALLLCESRN--ASLAHVPDPYTQAFLTQAARG----------LQTPLWIGLASEEGSR

human Pla2R   CTLD7      PMPNTLEYGNRTYKIINA-----NMTWYAAIKTCLMHK--AQLVSITDQYHQSFLTVVLNR----------LGYAHWIGLFTTDNGL

mouse Pla2R   CTLD7      AIPSTLEYGNRTYKIIRG-----NMTWYAAGKSCRMHR--AELASIPDAFHQAFLTVLLSR----------LGHTHWIGLSTTDNGQ

human DEC-205 CTLD7      NASETVKYLNNLYKIIPK-----TLTWHSAKRECLKSN--MQLVSITDPYQQAFLSVQALL----------HNSSLWIGLFSQDDEL

mouse DEC-205 CTLD7      NTSKTVKYLNNLYKIISK-----PLTWHGALKECMKEK--MRLVSITDPYQQAFLAVQATL----------RNSSFWIGLSSQDDEL

human DEC-205 CTLD9      TLPQFMPYEDGIYSVIQK-----KVTWYEALNMCSQSG--GHLASVHNQNGQLFLEDIVKR----------DGFPLWVGLSSHDGSE

mouse DEC-205 CTLD9      TLPQFIPYKDGVYSVIQK-----KVTWYEALNACSQSG--GELASVHNPNGKLFLEDIVNR----------DGFPLWVGLSSHDGSE

 

human MMR     CTLD8      TAWI--PFMGHCYYIESS----YTRNWGQASLECLRMG--SSLVSIESAAESSFLSYRVEK----------SKTNFWIGLFRNVEG-

mouse MMR     CTLD8      TAWI--PFYGHCYYFESS----FTRSWGQASLECLRMG--ASLVSIETAAESSFLSYRVEPLK--------SKTNFWIGMFRNVEG-

human Endo180 CTLD8      SAWI--PFREHCYSFHMEL----LLGHKEARQRCQRAG--GAVLSILDEMENVFVWEHLQSYE-------GQSRGAWLGMNFNPKGG

mouse Endo180 CTLD8      SSWI--PFREHCYSFHMEV----LLGHKEALQRCQKAG--GTVLSILDEMENVFVWEHLQTAE-------AQSRGAWLGMNFNPKGG

human Pla2R   CTLD8      IPWI--KFKSNCYKFSTVLD---SMSFEAAHEFCKKEG--SNLLTIKDEAENAFLLEELFAFG-------SSVQMVWLNAQFDGNNE

mouse Pla2R   CTLD8      VPWI--KFKGNCYSFSTVLD---SRSFEDAHEFCKSEG--SNLLAIRDAAENSFLLEELLAFG-------SSVQMVWLNAQFDNNNK

human DEC-205 CTLD8      TPWI--PFQNCCYNFIITKNRHMATTQDEVHTKCQKLNPKSHILSIRDEKENNFVLEQLLYF---------NYMASWVMLGITYRNK

mouse DEC-205 CTLD8      TPWI--PFQNSCYNFMITNNRHKTVTPEEVQSTCEKLHPKAHSLSIRNEEENTFVVEQLLYF---------NYIASWVMLGITYENN

human DEC-205 CTLD10     SRWI--QYKGHCYKSDQA-----LHSFSEAKKLCSKHDHSATIVSIKDEDENKFVSRLMRENN-------NITMRVWLGLSQHSVDQ

mouse DEC-205 CTLD10     PQWV--QYGGHCYASDQV-----LHSFSEAKQVCQELDHSATVVTIADENENKFVSRLMRENY-------NITMRVWLGLSQHSLDQ 

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CTLD - C-TERMINAL PORTION

 

human MMR     CTLD1      --GWQWSDR----SPFRYL--NWLP--GSPSAE-----------PGKSCVSLNPGKN--------------AKWENLECVQKLG-YICKK

mouse MMR     CTLD1      --GWQWAGG----SPFRYL—NWLP---GSPSSE-----------PGKSCVSLNPGKN--------------AKWENLECVQKLG-YICKK

human Endo180 CTLD1      --GWQWSDN----SPLKYL--NWES--DQPDNP-----------SEENCGVIRTESS--------------GGWQNRDCSIALP-YVCKK

mouse Endo180 CTLD1      --GWQWSDN----SPLKYL--NWES--DQPDNP-----------GEENCGVIRTESS--------------GGWQNHDCSIALP-YVCKK

human Pla2R   CTLD1      --GWQWSDG----TPLNYL--NWSP---EVNFEPF---------VEDHCGTPSSFMP--------------SAWNSRDCESTLP-YICKK

mouse Pla2R   CTLD1      --GWQWSDG----TPLSYL--NWSQ---EITPGPF---------VEHHCGTLEVVS---------------AAWRSRDCESTLP-YICKR

human DEC-205 CTLD1      --GWEWSDH----KPLNFL--NWDP--DRPSAPTI---------GGSSCARMDAES---------------GLWQSFSCEAQLP-YVCRK

mouse DEC-205 CTLD1      --GWEWSDF----RPLKFL--NWDP--GTPVAPVI---------GGSSCARMDTES---------------GLWQSVSCESQQP-YVCKK

 

human MMR     CTLD2      --YFEWSDG----TPVTFT--KWLR--GEPSHENN---------RQEDCVVMKGKD---------------GYWADRGCEWPLG-YICKM

mouse MMR     CTLD2      --YFEWSDG----TPVTFT--KWLP--GEPSHENN---------RQEDCVVMKGKD---------------GYWADRACEQPLG-YICKM

human Endo180 CTLD2      --NFEWSDG----SLVSFT--HWHP--FEPNNFRD---------SLEDCVTIWGPE---------------GRWNDSPCNQSLP-SICKK

mouse Endo180 CTLD2      --NFEWSDG----SLVSFT--HWHP--FEPNNFRD---------SLEDCVTIWGPE---------------GRWNDSPCNQSLP-SICKK

human Pla2R   CTLD2      --SFEWSND----SSVIFT--NWHT--LEPHIFPN---------RSQLCVSAEQSE---------------GHWKVKNCEERLF-YICKK

mouse Pla2R   CTLD2      --SFEWSSG----SSVIFT--NWYP--LEPRILPN---------RRQLCVSAEESD---------------GRWKVKDCKERLF-YICKK

human DEC-205 CTLD2      --LFQWSDG----TEVTLT--YWDE--NEPNVPYN---------KTPNCVSYLGEL---------------GQWKVQSCEELK--YVCKR

mouse DEC-205 CTLD2      --LFQWSDG----TEVTLT--YWNE--NEPSVPFN---------KTPNCVSYLGKL---------------GQWKVQSCEKKLR-YVCKK

 

human MMR     CTLD3      --TFQWTIE----EEVRFT--HWNS--DMPGRK-------------PGCVAMRTGIAG-------------GLWDVLKCDEKAK-FVCKH

mouse MMR     CTLD3      --TFRWTVD----EQVQFT--HWNA--DMPGRK-------------AGCVAMKTGVAG-------------GLWDVLSCEEKAK-FVCKH

human Endo180 CTLD3      --SFFWLSG----DEVMYT--HWNR--DQPGYS------------RGGCVALATGSAM-------------GLWEVKNCTSFRARYICRQ

mouse Endo180 CTLD3      --SFRWLSG----DEVIYT--HWNR--DQPGYR------------RGGCVALATGSAM-------------GLWEVKNCTSFRARYICRQ

human Pla2R   CTLD3      --EYTWKPVGQKPEPVQYT--HWNT--HQPRYS-------------GGCVAMRGRHPL-------------GRWEVKHCRHFKAMSLCKQ

mouse Pla2R   CTLD3      --EYTWKTVGQR-EPVQYT--YWNT--RQPSNR-------------GGCVVVRGGSSL-------------GRWEVKDCSDFKAMSLCKT

human DEC-205 CTLD3      --EYNWATVGGRRRAVTFS--NWNF--LEPASP-------------GGCVAMSTGKSV-------------GKWEVKDCRSFKALSICKK

mouse DEC-205 CTLD3      --EYSWAVAQGVKQAVTFS--NWNF--LEPASP-------------GGCVAMSTGKTL-------------GKWEVKNCRSFRALSICKK

 

human MMR     CTLD4      --GFTWSDG----SPVSYE--NWAY--GEPNNYQ----------NVEYCGELKGDPT--------------MSWNDINCEHLNN-WICQI

mouse MMR     CTLD4      --GFTWSDG----SPVSYE--NWAY--GEPNNYQ----------NVEYCGELKGDPG--------------MSWNDINCEHLNN-WICQIQ

human Endo180 CTLD4      GQSWRWSDG----VGFSYH--NFDR--SRHDDD-----------DIRGCAVLDLAS---------------LQWVAMQCDTQLD-WICKI

mouse Endo180 CTLD4      GHSWRWSDG----LGFSYH--NFAR--SRHDDD-----------DIRGCAVLDLAS---------------LQWVPMQCQTQLD-WICKI

human Pla2R   CTLD4      AGSWEWSDR----TPVVSS--FLDN--TYFGED------------ARNCAVYKPN----------------KTLLPLHCGSKRE-WICKI

mouse Pla2R   CTLD4      AGSWAWSDG----SPVVSS--FLDN--AYFEED------------AKNCAVYKAN----------------KTLLPSNCASKHE-WICRI

human DEC-205 CTLD4      QGSWQWSDR----TPVSTI--IMPN-EFQQDYD------------IRDCAAVKVFHRPWRRGWHFYDDREFIYLRPFACDTKLE-WVCQI

mouse DEC-205 CTLD4      QGSWQWSDR----TPVSAV--MMEP-EFQQDFD------------IRDCAAIKVLDVPWRRVWHLYEDKDYAYWKPFACDAKLE-WVCQI

 

human MMR     CTLD5      --KFAWMDG----SKVDYV--SWAT--GEPNFAN----------EDENCVTMYSNS---------------GFWNDINCGYPNA-FICQR

mouse MMR     CTLD5      --KFIWMDG----SKVDFV--AWAT--GEPNFAN----------DDENCVTMYTNS---------------GFWNDINCGYPNN-FICQR

human Endo180 CTLD5      --RFRWTDG----SIINFI--SWAP--GKPRPVG----------KDKKCVYMTASR---------------EDWGDQRCLTALP-YICKR

mouse Endo180 CTLD5      --RFRWTDG----SIINFI--SWAP--GKPRPIG----------KDKKCVYMTARQ---------------EDWGDQRCHTALP-YICKR

human Pla2R   CTLD5      --EFRWRDG----TPVIYQ--NWDT--GRERTVNN---------QSQRCGFISSIT---------------GLWGSEECSVSMP-SICKR

mouse Pla2R   CTLD5      --QIQWSNG----SPVIFQ--NWDK--GREERVDS---------QRKRCVFISSIT---------------GLWGTENCSVPLP-SICKR

human DEC-205 CTLD5      ----EWPID----DHFTYSRYPWHR---FPVTF------------GEECLYMSAKTWLI------------DLGKPTDCSTKLP-FICEK

mouse DEC-205 CTLD5      ----ENPID----RYFLGSRRRLWHH--FPMTF------------GDECLHMSAKTWLV------------DLSKRADCNAKLP-FICER

 

human MMR     CTLD6      --TFLWTDG----RGVHYT--NWGK--GYPGGRRSS---LSY--EDADCVVIIGGASNEA-----------GKWMDDTCDSKRG-YICQT

mouse MMR     CTLD6      --MFLWTAG----QGVHYT--NWGK--GYPGGRRSS---LSY--EDADCVVVIGGNSREA-----------GTWMDDTCDSKQG-YICQT

human Endo180 CTLD6      --DFQWVEQ----EPLMYA--NWAP--GEPSGPSPA---PSGN-KPTSCAVVLHSPSAHFT----------GRWDDRSCTEETHGFICQK

mouse Endo180 CTLD6      --DFQWIEQ----EPLLYT--NWAP--GEPSGPSPA---PSGT-KPTSCAVILHSPSAHFT----------GRWDDRSCTEETHGFICQK

human Pla2R   CTLD6      ---ETWLNG----KPVVYS--NWSP--FDIINIPSHNTTEVQK-HIPLCALLSSNPNFHFT----------GKWYFEDCGKEGYGFVCEK

mouse Pla2R   CTLD6      ---EKWVNG----KPLVYS--NWSP--SDIINIPSYNTTEFQK-HIPLCALMSSNPNFHFT----------GKWYFDDCGKEGYGFVCEK

human DEC-205 CTLD6      --INKWTDN----RELTYS--NFHP--LLVSGRLRIPENFFEEESRYHCALILNLQKSPFT----------GTWNFTSCSERHFVSLCQK

mouse DEC-205 CTLD6      --INRWTDN----RELTYS--NFHP--LLVGRRLSIPTNFFDDESHFHCALILNLKKSPLT----------GTWNFTSCSERHSLSLCQK

 

human MMR     CTLD7      --QYTWTDK----WRVRYT--NWAA--DEPKLK-------------SACVYLDLD----------------GYWKTAHCNESFY-FLCKR

mouse MMR     CTLD7      --EYTWTDR----WRVRYT--NWGA--DEPKLK-------------SACVYMDVD----------------GYWRTSYCNESFY-FLCKK

human Endo180 CTLD7      --RYSWVSE----EPLNYV--GWQD--GEPQQP-------------GGCTYVDVD----------------GAWRTTSCDTKLQGAVCGV

mouse Endo180 CTLD7      --RYSWLSE----EPLNYV--SWQD--EEPQHS-------------GGCAYVDVD----------------GTWRTTSCDTKLQGAVCGV

human Pla2R   CTLD7      --NFDWSDG----TKSSFT--FWKD----EESS-----------LLGDCVFADSN----------------GRWHSTACDSFLQGAICHV

mouse Pla2R   CTLD7      --TFDWSDG----TKSPFT--YWKD----EESA-----------FLGDCAFADTN----------------GRWHSTACESFLQGAICHV

human DEC-205 CTLD7      --NFGWSDG----KRLHFS--RWA-----ETNG-----------QLEDCVVLDTD----------------GFWKTVDCNDNQPGAICYY

mouse DEC-205 CTLD7      --NFGWSDG----KRLQFS--NWA-----GSNE-----------QLDDCVILDTD----------------GFWKTADCDDNQPGAICYY 

human DEC-205 CTLD9      -SSFEWSDG----STFDYI--PWKG----QTSP-------------GNCVLLDPK----------------GTWKHEKCNSVKDGAICYK

mouse DEC-205 CTLD9      -SSFEWSDG----RAFDYV--PWQS----LQSP-------------GDCVVLYPK----------------GIWRREKCLSVKDGAICYK

 

human MMR     CTLD8      --TWLWINN----SPVSFV--NWNT--GDPSGE------------RNDCVALHASS---------------GFWSNIHCSSYKG-YICKR

mouse MMR     CTLD8      --KWLWLND----NPVSFV--NWKT--GDPSGE------------RNDCVVLASSS---------------GLWNNIHCSSYKG-FICKM

human Endo180 CTLD8      --TLVWQDN----TAVNYS--NWGPPGLGPSMLS-----------HNSCYWIQSNS---------------GLWRPGACTNITMGVVCKL

mouse Endo180 CTLD8      --TLVWQDN----TAVNYS--NWGPPGLGPSMLS-----------HNSCYWIQSSS---------------GLWRPGACTNITMGVVCKL

human Pla2R   CTLD8      --TIKWFDG----TPTDQS--NWGIR--KPDTDYF---------KPHHCVALRIPE---------------GLWQLSPCQEKKG-FICKM

mouse Pla2R   CTLD8      --TLRWFDG----TPTEQS--NWGLR--KPDMDHL---------KPHPCVVLRIPE---------------GIWHFTPCEDKKG-FICKM

human DEC-205 CTLD8      --SLMWFDK----TPLSYT--HWRA--GRPTIK-----------NEKFLAGLSTD------GFWDIQT--FKVIEEAVYFHQHSILACKI

mouse DEC-205 CTLD8      --SLMWFDK----TALSYT--HWRT--GRPTVK-----------NGKFLAGLSTD------GFWDIQS--FNVIEETLHFYQHSISACKI

human DEC-205 CTLD10     --SWSWLDG----SEVTFV--KWEN---KSKSG------------VGRCSMLIASN---------------ETWKKVECEHGFGRVVCKV

mouse DEC-205 CTLD10     --SWSWLDGL----DVTFV--KWEN---KTKDG------------DGKCSILIASN---------------ETWRKVHCSRGYARAVCKI 

 

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

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TRANSMEMBRANE REGION and CYTOPLASMIC TAIL

 

human MMR      PKIIDAKPTHELLTTKADTRKMDP-SKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRR-VHLPQEGAFENTLYFNSQSSPGTSDMKDLVGNIEQNEHSVI

mouse MMR      PKIIDPVTTHSSITTKADQRKMDPQPKGSSKAAGVVTVV-LLIVIGAGVAAYFFYKKRHALHIPQEATFENTLYFNSNLSPGTSDTKDLMGNIEQNEHAII 

human Endo180               PRAEQSSFSPSA-LPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGARYSRSSSS-PTEATEKNILVSDMEMNEQQE

mouse Endo180               PRVEENSFLPSAALPESPVALVVVLTAVLLLLALMTAALILYRRRQSAERGSFEGARYSRSSHSGPAEATEKNILVSDMEMNEQQE

human Pla2R                 EADIHTAEALPEKGPSHSIIPLAVVLTLIVIVAICTLSFCIYKHNGGFFRRLAGFRNPYYPATNFSTVYLEENILISDLEKSDQ 

mouse Pla2R                 EAGIPAVTAQPEKGLSHSIVPVTVTLTLIIALGIFMLCFWIYKQKSDIFQRLTGSRGSYYPTLNFSTAHLEENILISDLEKNTN>

                                                                                         DEEVRDAPATESKRGHKGRPICISP

human DEC-205                           PLGPDYTAIAIIVATLSILVLMGGLIWFLFQRHRLHLAGFSSVRYAQGVNEDEIMLPSFHD

mouse DEC-205                           PLSPDYTGIAILFAVLCLLGLISLAIWFLLQRSHIRWTGFSSVRYEHGTNEDEVMLPSFHD

 

TRANSMEMBRANE REGION

 

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This page last updated:	Thursday, 09 March 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk