Group V - NK cell receptors

Joint human/mouse sequence alignment

Human sequence alignment

Introduction

If alignments appear scrambled please maximize the width of your browser window.

 

CYTOPLASMIC DOMAIN

 

  human LDLR                                                             MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWW

  mouse LDLR                                                             MTFDD-KMKPANDEPDQKSCGKKPKGLHLLSSPWW

human CLEC9A                                                                MHEEEIYTSLQWDSPAPDTYQKCLSSNKCSGA

mouse CLEC9A                                                                MHAEEIYTSLQWDIPTSEASQKCQSPSKCSGA

human Dectin                                                    MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWR

mouse Dectin                                                    MKYHSHIENLDEDGYTQLDFSTQDIHKRPRGSEKGSRAPSSPWR

 mouse KLRH1                                                               MNDERPTYAQLKLSKKSKDKKQSTQKKKEYPWR

 human CLEC1                                                MQAKYSSTRDMLDDDGDTTMSLHSQASATTRHPEPRRTEHRAPSSTWR

 mouse CLEC1                                                MQAKYSSTRDMLDDD-DTTISLYSGTSTVTRRAEPRHSENGTPSSVWR

 human CLEC2                                                                 MQDEDGYITLNIKTRKPALVSVGSASSSWWR

 mouse CLEC2                                                                 MQDEDGYITLNIKPRKQALSSAEPASS-WWR

human CLEC1D                                                        MSEEVNYATLTFQDSAGARNNRDGNNLRKRGHPAPSPIWR

mouse CLEC1D                                                        MSDEVTYATLMLQDSARVRGNRDGNNLRKEGHPAQSSLWR

  human MAFA                                                                MTDSVIYSMLELPTATQAQNDYGPQQKSSSSR

  mouse MAFA                                                                MADSSIYSTLELPEAPQVQDESRWKLKAVLHR

  human CD94                                                                                      MAVFKTTLWR

  mouse CD94                                                                                      MAVSRITRWR

human CLEC2A                                                                     MINPELRDGRADGFIHRIVPKLIQNWK

human CLEC2D                                                           MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWR

mouse CLEC2D                                                       MCVTKASLPMLSPTGSPQEVEVGKILQGKRHGTISPESCAK

mouse CLEC2E                                                            MLKTDLTAPDCLQEGEMGKKLQAKCLRIISTASCVK

mouse CLEC2H                                                           MLQRADLTAADCLQEGEMGKKIQGKCFRIISTVSPVK

mouse CLEC2I                                       MPDCLETGEKLFVHNMNAQCVQKPEEGNGPLGTG----GKIVQGKCFRIISTVSPVK

mouse CLEC2F                                                      MNAQCLKKPEEGESSPGTG----DKILQRNSLRAISPESSAK

mouse CLEC2G                                                      MNAQCLKKPEEGESSPGTGGVHSYKILQRNSLRAISPESSAK

mouse CLEC2D1                              MTCPGTCPRSSSSILVGTTQNVQTQEHLREIFTKFLKLAFLYSYLTGKILQGKSLRTIFPESPAK

mouse CLEC15A                                                                    MQTDTSPRLPQTSHERRHHRLMFDAKK

human NKRP1A                                                      MDQQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALK

mouse NKRP1A                                                      MDTARVYFGLKPPRTPGAWHESPPSLPPDACRCPRSHRSALK

mouse NKRP1C                                                      MDTASIYLGLKPPRTLGAWHESPPSLPPDACRCPRSHRLALK

mouse NKRP1B                                                     MDSTTLVYADLNLARIQEPKHDSPPSLSPDTCRCPRWHRLALK

mouse NKRP1D                                                     MDSTTLVYADLNLARIQEPKHDSPPSLSPDTCRCPRWHRLALK

mouse NKRP1F                                                      MDTSKVHGNVKPFRCPGYKQASSPSFSPDACRCPHWHHLALK

mouse NKRP1H                                                        MHPQCAAEIKSGGMVTGQKGFGARSIDACQGPGWHRVALK

mouse NKRP1E

 human KLRF1                                                          MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYK

 mouse KLRI1                MLHSKRREYTANNQDVTYTELKTCKSPWKHRIPTVKQSPVVLCEEQLKYGELTFHRTPQPQPRKQAMGRKRHGPKSTVWR

 mouse KLRI2                 MHKKKHIKHGTNKQEIINIGTKSPTFQEKQRPSKTDQRSTVWREEQKKQELKVHRIFHPQPRTGFDVGKGIDPWLTTWQ

 human MDL-1                           MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGT

 mouse MDL-1                           MNWHMIISGLIVVVIKVVGMTFFLLYFSQIFGRNDESTMPTRSYGT-----------------------                      

human DCAL-1                                      MVSNFFHVIQVFEKSATLISKTEHIGFVIYSWRKSTTHLGSRRKFAISIYLSEVSLQK

  human AICL                                                                                         MMTKHKK

  human CD69                                                          MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQ

  mouse CD69                                                          MDSENCSITENSSSHLERGQKDHGTSIHFEKHHEGSIQ

human CLEC2L   MSHTILLIQTTKRPEGRTYADYESVNECMEGVCKMYEEHVKRMNPNSPSIKYDISQLFDFINDLADLSCLWDWRWDGRWDVEPLSLLLDTTTR                  

mouse CLEC2L                                                                ....PEGLLRRSGSGYEGSTSWKAALEDTTTR

 human NKG2A                      MDNQGVIYSDLNLPPNPKRQQRKPKGNKSSILATEQEITYAELNLQKASQDFQGNDKTYHCKDLPSAPEKLIVG

 mouse NKG2A                      MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKGFPSPPEKLIAG      

 mouse NKG2B                      MSNERVTYAELKVAKNSRNQHRKPRGPRSSISVIEQEIIYSDFSFQNPSQEHPWICRNCPCKGFPSPPEKLIAG

 mouse NKG2C                      MSHLLGTEQAS----EPRKATKKTQAQFR--FSNAAGDRLLEFSLQHASQKHLKASRHGYCKNFASPPEKLIAG

 mouse NKG2E                      MSHLLGTEQAS----EPRKATKKTQAQLR--FSNAAGDRLLEFSLQHASQKHLKAS-HGYCKNFASPPEKLIAG

 human NKG2C                      MSKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAE

 human NKG2E                      MNKQRGTFSEVSLAQDPKPQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAE

 human NKG2H                      MNKQRGTFSEVSLAQDPKPQQRKPKGNKSSISGTEQEIFQVELNLQNASLNHQGIDKIYDCQGLLPPPEKLTAE

 human NKG2D                                  MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCREN-------------

 mouse NKG2D                                  MALIRDRKSHHS-EMSKCHNYDLKPAKWDTSQEQQKQRLALTTSQPGENGIIRGRYPIEKLK

 mouse NKG2I                            MDEAPVTRSTLNVNSQQKSKAKNKIKNTLNSNELSSIEQRKKYQKHLKKHKNTAEDISGKGNCSPPWR

  human CD72  MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLR

  mouse CD72  MADAITYADLRFVKVPLKNSASNHLGQDCEAYEDGELTYENVQVSPVPGGPPGLASPALADKAGVGSEQPTATWSSVKSSALRQIPRCPTVCLQ

 

ITIM     LL     YXXL

 

Return to top ↑

 

 

 

TRANSMEMBRANE DOMAIN and NECK REGION

 

  human LDLR         CLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQIS>

                                                   ARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVAN-CSA

  mouse LDLR         MTLFPAAVILCLVLSVTLIVQWTQLRQVSDLLKQYQANLTQQDRILEGQML>

                                                   AQQKAENASQESKKELKGKIDTLTQKLNEKSKEQEELLQKNQNLQEALQRAANSSE>

                                                             ESQRELKGKIDTITRKLDEKSKEQEELLQMIQNLQEALQRAANSSE>

                                                             ESQRELKGKIDTLTLKLNEKSKEQEELLQKNQNLQEALQRAANFSG

human CLEC9A       CCLVMVISCVFCMGLLTASIFLGVKLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSS

mouse CLEC9A       WCVVTMISCVVCMGLLATSIFLGIKFFQVSSLVLEQQERLIQQDTALVNLTQWQRKYTLE--YCQALLQRSLHSGTDASTGPVLLTSPQMVPQTLDSKETGSDCS 

human Dectin       LIAVILGILCLVILVIAVVLGTMGVLSS

mouse Dectin       PIAVGLGILCFVVVVVAAVLGALAFWRHNSGRNPEEKDNFLSRNKENHKPTESSLDEKVAPSKASQTTGGFSQ

 mouse KLRH1       ISVVILGTVCLCLLISSTVFGYWFFQATSNFKIQYEKDKNESAVSSMEVVHSSGLLLTAARKGCY

 human CLEC1       PVALTLLTLCLVLLIGLAAWGLLFFQYYQLSNTGQDTISQMEERLGNTSQELQSLQVQNIKLAGSLQHVAEKLCRELYNKAGAHRCS

 mouse CLEC1       PVALTLLTLCLVLLVGLAALGLVFFQFYQLSNIQQDSITEKDEKLGNMSRQLQSLQAQNRKLIETLQQVAVKLCRELYNKSGGHRCS

 human CLEC2      VMALILLILYVGMVVGLVALGIWSVMQRNYLQDENENRTGTLQQLAKRFCQYVVKQSELKGTFKG-HKCS

 mouse CLEC2      VMALVLLISSMGLVVGLVALGIMSVTQQKYLLAEKENLSATLQQLAKKFCQELIRQSEIKTKSTFEHKCS

human CLEC1D       HAALGLVTLCLMLLIGLVTLGMMFLQISNDINSDSEKLSQLQKTIQQQQDNLSQQLGNSNNLSMEEEFLKSQISSLLKRQEQMAIKLCQELIIHTSDHRCN

mouse CLEC1D       GAALSLMTLCLVLVTGLVTLATMFLQVSNDINSDSEKLSQLQKSIHPQQDNLSESLNSSRK-SLTEESLQSQISALLERQEQMATKLCKEFLIHASDHKCN

  human MAFA   PSCSCLVAIALGLLTAVLLSVLL-YQWILCQGSNYSTCASCP

  mouse MAFA   PHLSRFAMVALGLLT-VILMSLLMYQRILCCGSKDSTCSHCP

  human CD94           LISGTLGIICLSLMATLGILLKNSFTKLSIEPAFTPGPNIELQKDSDCC

  mouse CD94           LMSVIFGIKCLFLMVTLGVLLINSFTIQNIQSTPSPTTTVEFQEVSECC

human CLEC2A       IGLMCFLSIIITTVCIIMIATWSKHAKPV

human CLEC2D         LFFLIMFLTIIVCGMVAALSAIRANCHQEPSVCLQA

mouse CLEC2D      LYCYYGVIMVLTVAVIALSVALSATKTEQIPVNKTYA

mouse CLEC2E      LYCCYGVIMVLTVAVVALSVALSVRKKKPVMESCEPCYA

mouse CLEC2H      LYCCYGVIMVLTVAVIALSVALSVRNKIPAMEDREPCYT

mouse CLEC2I      LYCCYGVIMVLTVAVIALSVALSTKKTEQIIINKTYA

mouse CLEC2F      LYCCCGVIMVLTVAVVALSVALPATKTEQILINKTYA

mouse CLEC2G      LYCCCGVIMVLTVAVVALSVALPVTKTEQILINKTYA 

mouse CLEC2D1     LYCCCGVIMVLTVAVVALSVALSATKTEQILVNKTYA

mouse CLEC15A   VLTLWTLLGGAVAVLLWGFFSFPRKFTVTRTAR-NKTCDDEVK

human NKRP1A        LSCAGIILLVLVVTGLSVSVTSLIQKSSIEKCSVDIQQSRNKTTERPGLL

mouse NKRP1A        LSCAGLILLVVTLIGMSVLVRVLIQKPSIEKCYVLIQENLNKTTDCSAKL

mouse NKRP1C        LSCAGLILLVLTLIGMSVLVRVLVQKPSREKCCVFIQENLNKTT---VNL

mouse NKRP1B        FGCAGLILLVLVVIGLCVLV-LSVQKSSVQKICADVQENRTHTTDCSVNL

mouse NKRP1D        FGCAGLILLVLVVIGLCVLV-LSVQKSSVQKICADVQENRTHTTGCSAKL

mouse NKRP1F        SGCAGLILLLLSLIGLSVLVRFLVQKPPIEKCSVAAQENRTELTGRSAIL

mouse NKRP1H        LGCAGLI---FLLMVLSVLVGFLVQKPLIEKCSVAVQENRTEPTGRSATL

mouse NKRP1E                                               ...VLDCPAEL

 human KLRF1       ILLGISGTVNGILTLTLISLILLVL

 mouse KLRI1       VVTGMLGALCVVLMTTTGILLPKLFSSQEEQCRKTSL-HPLRCPK-DDASCD

 mouse KLRI2       MITVILATLCIILVTKVGFLIPSLFSKGEKQSRKFSLLDPL-CDRNDDSSCD

human DCAL-1       YDCPFSGTSFVVFSLFLICAMAGDVVYADIKTVRTSPLELAFPLQRSVSFNFSTVHK

  human AICL              CFIIVGVLITTNIITLIVKLTRDSQS

  human CD69      VPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFSMPSDSHVS

  mouse CD69      VSIPWAVLIVVLITSLIIALIALNVGKYNCPGLYEKLESSDHHVA       

human CLEC2L          LLLGAIAVLLFAILVVMSILASKGCIKCEA

mouse CLEC2L          LLLGAIAVLLFAILVVMSILASKGCIKCET

 human NKG2A         ILG-IICLI--LMASVVTIVVIPSTLIQRHNNSSLNTRTQK---------ARHCG

 mouse NKG2A         TLG-LICFVLIVAVVVITTVATPYTEAKAQINSSM-TRTHRDINYTLSS-AQPCP

 mouse NKG2B         TLG-LICFVLIVAVVVITTVATPYI------------------NYTLSS-AQPCP

 mouse NKG2C         ILGTIWFTL-LIALVISTRIVSPS--------------------------QPCP

 mouse NKG2E         ILGTIWFTL-LIALVISTRIVSPYIN--HSLSSAQTYA

 human NKG2C         VLG-IICIV-LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARHCG   

 human NKG2E         VLG-IICIV-LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARPCG

 human NKG2H         VLG-IICIV-LMATVLKTIVLIPFLEQ--NNSSPNTRTQK---------ARPCG

 human NKG2D ASPFFFCCFIAVAMGIRFII---MVAIWSAVFLNS-LFN-------Q-EVQIPLTES--YCG

 mouse NKG2D ISPMFVVRVLAIALAIRFTLNTLMWLAIFKETFQPVLCN--------KEV--PVSSREGYCG

 mouse NKG2I        LLSSVLGAMCLLLMAVAMVMTTFTTKSSSERSSSTIQQEGLHH

 human CD72     YLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQ>

                                                                        KTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADT

 mouse CD72     NFLLGLLLSCLMLGVAVICLGVRYLQVSQQFQEGTRIWEATNSSLQQQLREKISQLGQKEVELQESQKELISSQDTLQEKQRTHKDTEQQLQACQAERA>

                                                                        KTKENLKTEEERRRDLDQRLTSTRETLRRLSSCSS-DT

TRANSMEMBRANE REGION

 

Return to top ↑

 

 

 

CTLD - N-TERMINAL

 

  human LDLR  PCPQDWIWHGE--NCYLFSS-GSFNWEKSQEKCLSLDAK---LLKINST-ADLDFIQQAISYSS--FPFWMGL

  mouse LDLR  PCPQDWLWHKE--NCYLFH--GPFSWEKNRQTCQSLGGQ---LLQINGA-DDLTFILQAISHTT--SPFWIGL

human CLEC9A  PCPNNWIQNRE--SCYYVSE-IWSIWHTSQENCLKEGST---LLQIESK-EEMDFITGSLRKIKGSYDYWVGL

mouse CLEC9A  PCPHNWIQNGK--SCYYVFE-RWEMWNISKKSCLKEGAS---LFQIDSK-EEMEFIS-SIGKLKGGNKYWVGV
human Dectin  PCPPNWIIYEK--SCYLFSM-SLNSWDGSKRQCWQLGSN---LLKIDSS-NELGFIVKQV-SSQPDNSFWIGL

mouse Dectin  SCLPNWIMHGK--SCYLFSF-SGNSWYGSKRHCSQLGAH---LLKIDNS-KEFEFIESQT-SSHRINAFWIGL       

 mouse KLRH1  TCQGGWSCCGG--KCYFFSE-EEKTWDESEASCKVLGSL---LAKIDSR-EEQNFIQSQVNY-----SYWVGL

 human CLEC1  PCTEQWKWHGD--NCYQFYK-DSKSWEDCKYFCLSENST---MLKINKQ-EDLEFAASQS-YSEFFYSYWTGL

 mouse CLEC1  PCPEKWKWYGD--KCYQFYK-ESKNWQSCEYFCLADNAT---MLKISTQ-EELDFAMPQS-YSEFFYSYWTGL

 human CLEC2  PCDTNWRYYGD--SCYGFFR-HNLTWEESKQYCTDMNAT---LLKIDNR-NIVEYIK-----ARTHLIRWVGL

human CLEC1B2 PCDANWTYYGD--SCYGFFK-HNLTWKESEQYCTDMKAT---LLKTDNQ-NILEYIKA-----RTGLIHWVRL

 mouse CLEC2  PCATKWRYHGD--SCYGFFR-RNLTWEESKQYCTEQNAT---LVKTASQST-LDYIAERI----T-SVRWIGL

human CLEC1D  PCPKMWQWYQN--SCYYFTTNEEKTWANSRKDCIDKNST---LVKIDSL-EEKDFLM--SQPLLMFSFFWLGL

mouse CLEC1D  PCPKTWQWYGN--SCYYFSINEEKSWSDSRKDCIDKNAT---LVKIDST-EERDLLQ--SQLSLTFSFFWLGL

  human MAFA  SCPDRWMKYGN--HCYYFSV-EEKDWNSSLEFCLARDSH---LLVITDN-QEMSLLQ----VFLSEAFCWIGL

  mouse MAFA  SCPILWTRNGS--HCYYFSM-EKKDWNSSLKFCADKGSH---LLTFPDN-QGVKLFGE----YLGQDFYWIGL

  human CD94  SCQEKWVGYRC--NCYFISS-EQKTWNESRHLCASQKSS---LLQLQNT-DELDFMS------SSQQFYWIGL

  mouse CD94  VCLDKWVGHQC--NCYFISK-EEKSWKRSRDFCASQNSS---LLQPQSR-NELSFMN------FSQTFFWIGM

human CLEC2A  ACSGDWLGVRD--KCFYFSD-DTRNWTASKIFCSLQKAE---LAQIDTQ-EDMEFLK----RYAGTDMHWIGL
human CLEC2D  ACPESWIGFQR--KCFYFSD-DTKNWTSSQRFCDSQDAD---LAQVESF-QELNFLL----RYKGPSDHWIGL

mouse CLEC2D  ACPQNWIGVEN--KCFYFSE-YPSNWTFAQAFCMAQEAQ---LARFDNQ-DELNFLM----RYKANFDSWIGL

mouse CLEC2E  VCPSGWIGFGN--KCFYFSE-DMGNWTFSQSSCIALDAR---LALFDSL-EELNFLK----RYKGASDHWIGL 

mouse CLEC2H  ACPSGWIGFGS--KCFYFSE-DMGNWTFSQSSCVASNSH---LALFHSL-EELNFLK----RYKGTSDHWIGL

mouse CLEC2I  ACSKNWTGVGN--KCFYFSG-YPRNWTFAQAFCMAQEAQ---LARFDNE-EELIFLK----RFKGDFDCWIGL

mouse CLEC2F  ACPKNWIGVGN--KCFYFSE-YTSNWTFAQTFCMAQEAQ---LARFDNE-KELNFLK----R-HMNSSHWIGL

mouse CLEC2G  ACPKNWIGVGN--KCFYFSE-YTSNWTFAQTFCMAQEAQ---LARFDNE-KELNFLM----RYKANFDSWIGL

mouse CLEC2D1 ACPQNWIGSGN--KCFYFSE-YTSNWTFAQNFCMAQEAQ---LARFDNQ-DELNFLM----RYKGTFDFWIGL

mouse CLEC15A LCPKDWNKLRQ--NCFSRIQ-HKNSWLTANDTCELHDAT---LAVFIDK-TEVEILM---NQIQEMKTYWIGL

human NKRP1A  NCPIYWQQLRE--KCLLFSH-TVNPWNNSLADCSTKESS---LLLIRDK-DELIHTQ--NLIRDKAILFWIGL

mouse NKRP1A  ECPQDWLSHRD--KCFHVSQ-VSNTWEEGLVDCDGKGAT---LMLIQDQ-EELRFLL--DSIKEKYNSFWIGL

mouse NKRP1C  ECPQDWLLHRD--KCFHVSQ-VSNTWEEGQADCGRKGAT---LLLIQDQ-EELRFLL--DSIKEKYNSFWIGL

mouse NKRP1B  ECPQDWLSHRD--KCFRVFQ-VSNTWEEGQADCGRKGAT---LLLIQDQ-EELRFLL--DSIKEKYNSFWIGL

mouse NKRP1D  ECPQDWLSHRD--KCFHVSQ-VSNTWKECRIDCDKKGAT---LLPIQDQ-EELRFLL--DSIREKYNSFWIGL

mouse NKRP1F  ECPRYWHPHWN--KCLFVSQ-ISRPWAEGRDACSMEDAI---LLLIENK-EELRFVQ--NLIKGKEQLFFIGL

mouse NKRP1H  ECPRDWHPHCD--KCLFTSQ-TSRPWADGLVDCNLKGAT---LLLIQDE-EELRLLQ--NFSKGKGQQFYIGL

mouse NKRP1E  ECPQNWLSHRD--KCFCVSQ-VSNTWKEGQADCDRKGAT---LLLIQDQ-EELRFLQ--DLAKENYDSFWIGL

 human KLRF1  -CQSEWLKYQG--KCYWFSN-EMKSWSDSYVYCLERKSH---LLIIHDQ-LEMAFIQ---KNLRQLNYVWIGL

 mouse KLRI1  LCSSDWIAFGNNFYCV-FKE-NTKTWAESQSACEELNSH---LVIIDSKAEVENLLL-------FEMDGWILH

 mouse KLRI2  FCSSDWIAFGNNFYCV-FRE-NSKTWVESQSACEELNSH---LVIIDSKAEVENLLL-------FEMDGWILH

 human MDL-1  VCPKDWEFYQA--RCFFLST-SESSWNESRDFCKGKGST---LAIVNTP-EKLKFLQ----DITDAEKYFIGL

 mouse MDL-1  VCPRNWDF-HQG-KCFFFSF-SESPWKDSMDYCATQGST---LAIVNTP-EKLKYLQ----DIAGIENYFIGL

human DCAL-1  SCPAKDWKVHKG-KCYWIAE-TKKSWNKSQNDCAINNSY---LMVIQDITAMVRFNI

  human AICL  LCPYDWIGFQN--KCYYFSK-EEGDWNSSKYNCSTQHAD---LTIIDNI-EEMNFLR----RYKCSSDHWIGL

  human CD69  SCSEDWVGYQR--KCYFIST-VKRSWTSAQNACSEHGAT---LAVIDSE-KDMNFLK----RYAGREEHWVGL

  mouse CD69  TCKNEWISYKR--TCYFFST-TTKSWALAQRSCSEDAAT---LAVIDSE-KDMTFLK----RYSGELEHWIGL

human CLEC2L  PCPEDWLLYGR--KCYFFSE-EPRDWNTGRQYCHTHEAV---LAVIQSQ-KELEFMF----KFTRR-EPWIGL

mouse CLEC2L  PCPEDWLLYGR--KCYYFSE-EPRDWNTGRQYCHTHEAA---LAVIQSQ-KELEFMF----KFTRR-EPWIGL

 human NKG2A  HCPEEWITYSN--SCYYIGK-ERRTWEESLLACTSKNSS---LLSIDNE-EEMKFLS----IISP--SSWIGV

 mouse NKG2A  HCPKEWISYSH--NCYFIGM-ERKSWNDSLVSCISKNCS---LLYIDSE-EEQDFLQ----SLSL---SWTGI

 mouse NKG2B  HCPKEWISYSH--NCYFIGM-ERKSWNDSLVSCISKNCS---LLYIDSE-EEQDFLQ----SLSL--ISWTGI

 mouse NKG2C  HCPKEWISYSH--NCYFIGM-ERKSWNDSLGSCLSKNCS---LLHIDSE-EEQDFLQ----SLSL--VSWTGI

 mouse NKG2E  LCPKEWILYSH--NCYYIGM-ERKSWNDSLVSCISKNCS---LLYIDSE-EEQDFLQ----SLSL--VSWTGI

 human NKG2C  HCPEEWITYSN--SCYYIGK-ERRTWEESLLACTSKNSS---LLSIDNE-EEIKFLA----SILP--SSWIGV

 human NKG2E  HCPEEWITYSN--SCYYIGK-ERRTWEESLQACASKNSSS--LLSIDNE-EEMKFLA----SILP--SSWIGV

 human NKG2H  HCPEEWITYSN--SCYYIGK-ERRTWEESLQACASKNSSS--LLSIDNE-EEMKFLA----SILP--SSWIGV

 human NKG2D  PCPKNWICYKN--NCYQFFD-ESKNWYESQASCMSQNAS---LLKVYSK-EDQDLLK----LVKS--YHWMGL

 mouse NKG2D  PCPNNWICHRN--NCYQFFN-EEKTWNQSQASCLSQNSS---LLKIYSK-EEQDFLK----LVKS--YHWMGL

 mouse NKG2I  PCPENWVWFRC--SCYFFSK-EELIWRDSQRACLSLNSS---LIRMNKEEMNFFSLK---------SFFWVGV

  human CD72  CCPSGWIMHQK--SCFYISL-TSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGL

  mouse CD72  CCPCGWIPYQE--RCFYISH-TLRSLEESQKYCTSLSSKLAAFDEPSKYYYEVSLPSGLEELLDRSKSYWIQM

 

Return to top ↑

 

 

CTLD - C-TERMINAL

 

  human LDLR  SRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGA----VYAENCILAAFSICQKKANLRAQ

  mouse LDLR  HRKKPGQPWLWENGTPLNFQFFKTRGVSLQLYSSGNCAYLQDGA----VFAENCILIAFSICQKKTNH

human Dectin  SRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSV----IYDQLCSVPSYSICEKKFSM

mouse Dectin  SRNQSEGPWFWEDGSAFFPNSFQVRNTVPQESLLHNCVWIHGSE----VYNQICNTSSYSICEKEL                   

human CLEC9A  SQDGHSGRWLWQDGSSPSPGLLPAER--SQS-ANQVCGYVKSNS----LLSSNCSTWKYFICEKYALRSSV
mouse CLEC9A  FQDGISGSWFWEDGSSPLSDLLPAER---QRSAGQICGYLKDST----LISDKCDSWKYFICEKKAVWILHLKDTTQSYLLHKCLKEAKEQTQEEIDVRL
 mouse KLRH1  HKKGSQFQWVHHKDAKLSSDLDFH---TATHVADAECGYIKPKN----LNVAPCHRYFYYICKRNFTCPMT

 human CLEC1  LRPDSGKAWLWMDGTPFTSELFHI-IIDVTSPRSRDCVAILNGM----IFSKDCKELKRCVCERRAGMVKPESLHVPPETLGEGD

 mouse CLEC1  SRNGSGKAWLWTDGTPYSFELFEI-IIDPTNLRNRDCMTIFNGK----AYSKDCKELRRCACERIAGRVVPGELQ

 human CLEC2  SRQKSNEVWKWEDGSVISENMFEF---LEDGKGNMNCAYFHNGK----MHPTFCENKHYLMCERKAGMTKVDQLP

human CLEC1B2 SHQNSNEVFFEGIYSTFPIHRFGLSED---GKGNMNCAYFHNQK----RHSTFCENKHYLMCERKAGMAKVDQLP

 mouse CLEC2  SRQNSKKDWMWEDSSVLRKNGINL---SGNTEENMNCAYLHNGK----IHPASCKERHYLICERNAGMTRVDQLL                  

human CLEC1D  SWDSSGRSWFWEDGSVPSPSLFSTKELDQING-SKGCAYFQKGN----IYISRCSAEIFWICEKTAAPVKTEDLD

mouse CLEC1D  SWNSSGRNWLWEDGSFPPPTLLSDKELASFNG-SRECAYFERGN----IYTSRCRAEIPWICEKRASLVKIEDLD

  human MAFA  RNNS---GWRWEDGSPLNFSRISS------NSFVQTCGAINKNG----LQASSCEVPLHWVCKKVRL

  mouse MAFA  RNID---GWRWEGG-PALSLRILT------NSLIQRCGAIHRNG----LQASSCEVALQWICKKVLY

  human CD94  SYSEEHTAWLWENGSALSQYLFPS----FETFNTKNCIAYNPNGN---ALDESCEDKNRYICKQQLI

  mouse CD94  HYSEKRNAWLWEDGTVPSKDLFPE----FSVIRPEHCIVYSPSKS---VSAESCENKNRYICKKLPI

human CLEC2A  SRKQGDS-WKWTNGTTFNGWP----------------------------------SNSKWSCNWSLRQWLLLLGPLR 

human CLEC2D  SREQ-GQPWKWINGTEWTRQFPIL--------GAGECAYLNDKG----ASSARHYTERKWICSKSDIHV

mouse CLEC2D  HRESSEHPWKWTDNTEYNNTIPIR--------GEERFAYLNNNG----ISSTRIYSLRMWICSKLNSYSLHCQTPFFPS

mouse CLEC2E  HRESSEHPWIWTDNTEYNNLVLTR--------GGGECAYLSNRG----IYNSSGDIHKKWICNKPNSYTLQCPLIVNPG

mouse CLEC2H  HRASTQHPWIWTDNTEYSNLVLTR--------GGGECGFLSDNG----ISSGRSYTHRKWICSKFVSSCKSRVGSVPRHV

mouse CLEC2I  HRESSEHPWKWTNNTEYNNMNPIL--------GVGRYAYLSSDR----ISSSRSYINRMWICSKLNNYNLHCQTPPV

mouse CLEC2F  HRDSSEHPWRWTDNTEYNNTFLIQ--------GDGECGFLSDNG----ISSSRDYIPRKWICSRSSNYMLQC

mouse CLEC2G  HRESSEHPWKWTDNTEYNNMIPIQ--------GVETCAYLSGNG----ISSSRHYIPRIWICSKLNNYSLHCPTPVPV  

mouse CLEC2D1 HRESSERAWKWTDNTEYNNTDVFTIQGNEIH------GFLRDNG----ISSSRNYTERKWICSKSSNYTLLC

mouse CLEC15A HRQNLLGIWVWTNGSKYNNLHEIQ--------DHGQCAFVHQKG----IDSTSCEDQKEFICTREGQCP

human NKRP1A  NFSLSEKNWKWINGSFLNSNDLEI----RGDAKENSCISISQTS----VYSEYCSTEIRWICQKELTPVRNKVYPDS

mouse NKRP1A  RYTLPDMNWKWINGSTLNSDVLKI----TGDTENDSCAAISGDK----VTFESCNSDNRWICQKELYHETLSNYVGYGH

mouse NKRP1C  RFTLPDMNWKWINGTTFNSDVLKI----TGVTENGSCASILGDK----VTPESCASDNRWICQKELNHETPSNDS

mouse NKRP1B  RFTLPDMNWKWINGTTFNSDVLKI----TGDTENGSCASISGDK----VTSESCSTDNRWICQKELNHETPSNDS

mouse NKRP1D  SYTLTDMNWKWINGTAFNSDVLKI----TGVTENGSCAAISGEK----VTSEGCSSDNRWICQKELNHETPCNDS                        

mouse NKRP1F  KYVQKEKIWKWIDGSILNPNLLRI----TGKDKENSCAIISHTE----VFSDSCSSDNHWICQKTLIHV

mouse NKRP1H  KYEEVDKVWKWMNGSILNTNLLQI----TGKDEENSCALISQTE----VFSDSCSSDNHWICQKTLKHV

mouse NKRP1E  SYT--DKNWMWINGSTLNSDMNLFCFMFMSVCLHVYIHNCSQMGLGGVHRSQKRCIRSLGTRVPDTVSNYVGYGH

 human KLRF1  NFTSLKMTWTWVDGSPIDSKIFFI----KGPAKENSCAAIKESK----IFSETCSSVFKWICQY

 mouse KLRI1  KMDGTNSSWLWRNDIKIQNTLTND-----SEKKNHSCHYLRGNL----FMPDECSAKKSYICEFNI

 mouse KLRI2  RMDGTNSSRLWGNDIKIRNTLMND-----SEKKNHSCHYLRGNI----FMPDECSAKKTYICEFNI

 human MDL-1  IYHREEKRWRWINNSVFNGNVTNQ-------NQNFNCATIGLTKT---FDAASCDISYRRICEKNAK

 mouse MDL-1  VRQPGEKKWRWINNSVFNGNVTNQ-------DQNFDCVTIGLTKT---YDAASCEVSYRWICEMNAK

  human AICL  KMAK-NRTGQWVDGATFTKSFGMR--------GSEGCAYLSDDG----AATARCYTERKWICRKRIH

  human CD69  KKEP-GHPWKWSNGKEFNNWFNVT--------GSDKCVFLKNTE----VSSMECEKNLYWICNKPYK

  mouse CD69  KNE-ANQTWKWANGKEFNSWFNLT--------GSGRCVSVNHKN----VTAVDCEANFHWVCSKPSR

human CLEC2L  RRVG--DEFHWVNGDPFDPDTFTI-------AGPGECVFVEPTR----LVSTECLMTRPWVCSKMAYT

mouse CLEC2L  RRVG--DDFHWVNGDPFDPDTFTI-------SGMGECVFVEPTR----LVSTECLTTRPWVCSKMAYT

 human NKG2A  FRNSSHHPWVTMNGLAFKHEIKDS------DNAELNCAVLQVNR----LKSAQCGSSIIYHCKHKL

 mouse NKG2A  LRKGRGQPWVWKEDSIFKPKIAEI------LHDECNCAMMSASG----LTADNCTTLHPYLCKCKFPI

 mouse NKG2B  LRKGRGQPWVWKEDSIFKPKIAEI------LHDECNCAMMSASG----LTADNCTTLHPYLCKCKFPI

 mouse NKG2C  LRKGRGQAWDWKKDSIFKPKIAEI------SHDECNCAMMSASG----LTADNCTTLHPYLCKCKFP

 mouse NKG2E  LRKGRGQPWVWKKDSTFKPKIAEI------LHDECNCAMMSASG----LTADSCTTLHPYLCKCKFPI                          

 human NKG2C  FRNSSHHPWVTINGLAFKHKIKDS------DNAELNCAVLQVNR----LKSAQCGSSMIYHCKHKL

 human NKG2E  FRNSSHHPWVTINGLAFKHEIKDS------DHAERNCAMLHVRG----LISDQCGSSRIIRRGFIMLTRLVLNS

 human NKG2H  FRNSSHHPWVTINGLAFKHEIKDS------DHAERNCAMLHVRG----LISDQCGSSRIIVSISFRIKALELAVHQIKFYICSNRNDIMIA

 human NKG2D  VHIPTNGSWQWEDGSILSPNLLTI-----IEMQKGDCALYASSFK--GYIE-NCSTPNTYICMQRTV

 mouse NKG2D  VQIPANGSWQWEDGSSLSYNQLTL-----VEIPKGSCAVYGSSFK--AYTE-DCANLNTYICMKRAV

 mouse NKG2I  YYNETRRQWLWEDHSVLPSGLFSK----LEANMKNFCASYKSKE---AYMEENCANKLTYICKK  

  human CD72  SSNK---DWKLTDDTQRTRTYAQS----------SKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD

  mouse CD72  --SK---KWRHDYDSQS-----------------RYCDKIKKYYQKWKRTFSECAELHPCICESEAFRFPDGIHLN 

                

CONSERVED RESIDUES

 

Return to top ↑ 

______________________________________________________________________________________________________________________

This page last updated:	Thursday, 09 March 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk