Group X - Polycystin
- Human sequence alignment
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Mammalian
proteins containing CTLDs
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If alignments appear scrambled please maximize the width of your browser
window.
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N-TERMINAL REGION inc. SIGNAL SEQUENCE
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Human
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRV
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SIGNAL SEQUENCE
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LEUCINE-RICH REGION
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Human NCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSG
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Human
NPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGC
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LEUCINE-RICH REPEATS
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WSC DOMAIN and LINKER
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Human WSC
GEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQP
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Human Link SSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPH
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PKD REPEAT
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Human PKD1 GPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVE
Human
AAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHP
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CONSERVED RESIDUES
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CTLD
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Human LCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRCLDVWIGFSTVQGVE
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Human VGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCE
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CONSERVED CORE RESIDUES
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LINKER
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Human
LQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNR
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TQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGH
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PGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLY
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VPTNGSALVLQVDSGANATATARWPG
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LDL-RECEPTOR CLASS A
ATYPICAL
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PKD REPEATS
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- Human PKD2
GSVSARFENVCPALVATFVPGCPWETNDTLFSV--------------------------VALPWLSEGEHVVDVVVENSASRANLSLRVTAE
EPICGLRATPSPEA
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Human PKD3 RVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVV---------------------FNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVE
RMNRMQGLQVSTVPAVL
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Human PKD4 SPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVR
ASLPSVAVGVSDGV
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Human PKD5 LVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPA--------------------ANHTYASRGTYHVRLEVNNTVSGAAAQADVRVF
EELRGLSVDM
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Human PKD6 SLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEAT-------------------VEHVYLRAQNCTVTVGAASPAGHLARSLHVLVF
VLEVLRVEPAAC
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Human PKD7 IPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPT-------------------VTHNFTRSGTFPLALVLSSRVNRAHYFTSICVE
PEVGNVTLQPERQ
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Human PKD8 FVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPE-------------------VTFIYRDPGSYLVTVTASNNISAANDSALVEVQ
EPVLVTSIKVNGS
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Human PKD9 LGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPE-----------------------VTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVK
RRVRGLVVNASRT
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Human PKD10 VVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPT---------------------ISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVL
QLIEGLQVVGGGR--
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Human PKD11 YFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKG-------------------FSLTVLEAGTYHVQLRATNMLGSAWADCTMDFV
EPVGWLMVAASPN
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Human PKD12 PAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPF---------------------TTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQ
VPVSGLSIRASEPG
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Human PKD13 GSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPH---------------------VTMVFPDAGTFSIRLNASNAVSWVSATYNLTAE
EPIVGLVLWASSK
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Human PKD14 VVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPR---------------------FSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVL
EAVSGLQVPNCCEP
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Human PKD15 GIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRD----------------VTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQ
DAVQYVALQSGP
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Human PKD16 CFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPR--------------------AEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQ
VLA
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CONSERVED RESIDUES
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REJ DOMAIN
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Human
CREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANV
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TVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATN
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QTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEE
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EGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGA
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AVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIA
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AALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVL
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NEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNP
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LINKER
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Human
FPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEE
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PEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGL
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GPS DOMAIN
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Human
YTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPS
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MEMBRANE-SPANNING DOMAIN and CYTOPLASMIC TAIL
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Human HVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSL
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GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFL
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GANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEAFVGQMKSDLFLDDSKSLV
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CWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPG
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LNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSA
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RVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEA
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LYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEF
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PAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARG
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LAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVI
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LRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEA
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LLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST
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PREDICTED TRANSMEMBRANE REGIONS
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PLAT DOMAIN
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____________________________________________________________________________________________________________
- This page last updated:
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Thursday, 09 March 2006
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Animal
lectins home
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| Contact information: |
This site is
supported by: |
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- Kurt Drickamer
- Division of Molecular Biosciences
- Faculty of Natural Sciences
- Imperial College London
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- Email:
k.drickamer@imperial.ac.uk
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