Group XI - Attractin family

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

N-TERMINAL REGION

 

Human ATRN           M--VAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAVSGSAAAEAKE

Human ATRNL1         METGGRARTGTPQPAAPGVWRARPAGGGGGGASSW-----------------------------------LLDGNSWLLCYGFLYLALYAQVSQS-----KP

 

SIGNAL SEQUENCE

 

 

 

EGF DOMAIN

 

Human ATRN   EGF1    CDRP--CVNGGRCNPGTGQCVC-PAGWVGEQC

Human ATRNL1 EGF1    CERTGSCFSG-RCVNST--CLCDP-GWVGDQC

 

CONSERVED RESIDUES

 

 

 

CUB DOMAIN

 

Human ATRN           QHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDM

Human ATRNL1         QHCQGRFKLTEPSGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLIAVLSGLIVPEIRGNETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINS

 

CONSERVED RESIDUES

 

EGF DOMAINS

Human ATRN   EGF2    CPNNCSG--RGECKISNSS-DTVECECSENWKGEACDIPH

Human ATRNL1 EGF2    CPNNCSG--HGKCTTSVSVPSQVYCECDKYWKGEACDIPY

 

Human ATRN   EGF3    CTDNCGFPHRGICNSSDVRG----CSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLP

Human ATRNL1 EGF3    CKANCGSPDHGYCDLTGEKL----CVCNDSWQGPDCSLNVPSTESYWILPNVKPFSPSVG

 

CONSERVED RESIDUES

 

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KELCH REPEATS

 

Human ATRN   KELCH1  RASHKAVVNG--NIMWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVV  

Human ATRNL1 KELCH1  RASHKAVLHG--KFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGTPSRGPLQ-

 

Human ATRN   KELCH2  RYGHSLALYK--DKIYMYGGKIDST-GNVTNELRVFHIHNESWVLLTP---KAKEQYAVVGHSAHIVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQG  

Human ATRNL1 KELCH2  RYGHSLALYQ--ENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQG

 

Human ATRN   KELCH3  GYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFF

Human ATRNL1 KELCH3  GYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFA

 

Human ATRN   KELCH4  RYLHTAVIVS--GTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVN

Human ATRNL1 KELCH4  RYLHSAVLIN--GAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDVN

 

Human ATRN   KELCH5  RFGHSAVLHN--STMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHD-  

Human ATRNL1 KELCH5  RFGHSAVVIN--GSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELCKNAGPGIKCVWNKN--HCESWESGNTNNILRAK--CPPK-TAASDD

 

CONSERVED RESIDUES

 

 

 

CYSTEINE-RICH REPEATS - #1

 

Human ATRN   PLEX 1  RCDQHTDCYSCTANTNDCHWC--NDHCVPRNHSCSEGQISIFRYENCPKDNPMYY

Human ATRNL1 PLEX 1  RCYRYADCASCTANTNGCQWCD-DKKCISANSNCS---MSVKNYTKCHVRNEQI-

 

Human ATRN   PLEX 2  -CNKKTSCRSCALDQN-CQWEPRNQECI-ALPENICGIGWHLVGNSCLKITTA

Human ATRNL1 PLEX 2  -CNKLTSCKSCSLNLN-CQWDQRQQECQ-ALPAHLCGEGWSHIGDACLRVNSS

 

CONSERVED RESIDUES

 

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CTLD

 

Human ATRN           KENYDNAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVS

Human ATRNL1         RENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQ-Q---K--VSPWVGLRKINIS

 

Human ATRN           YWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRT----

Human ATRNL1         YWGWEDMSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMANGLVCEKP-VVSPNQNARPCKK

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

 

CYSTEINE-RICH REPEATS - #2

 

Human ATRN   PLEX 3  PCALRTACGDCTSGSSECMWC---SNM-K-QCVDSNAYVASFPFGQCMEWYTMSTCPPEN

Human ATRNL1 PLEX 3  PCSLRTSCSNCTSNGMECMWC---SST-K-RCVDSNAYIISFPYGQCLEWQT-ATCSPQN

 

Human ATRN   PLEX 4  -CSGYCTCSHCLEQPG-CGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPACQ

Human ATRNL1 PLEX 4  -CSGLRTCGQCLEQPG-CGWCNDPSNTGRGHCIEGSSRGPMKL-----IGMHHNEMVLDTNLCPKEKNYEWSFIQCPACQ

 

CONSERVED RESIDUES

 

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LAMININ EGF DOMAINS

Human ATRN   EGF1    CNGH-SKCINQSICEKCEN-LTTGKHCETC-ISGFY-GDPTNGGKCQPCK  

Human ATRNL1 EGF1    CNGH-STCINNNVCEQCKN-LTTGKQCQDC-MPGYY-GDPTNGGQCTACT  

 

Human ATRN   EGF2    CNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLRG-TC  

Human ATRNL1 EGF2    CSGHANICHLHTGKCFCTTKGIKGDQCQLCDSENRYVGNPLRG-TC  

 

CONSERVED RESIDUES

 

 

 

C-TERMINAL REGION inc. TRANSMEMBRANE DOMAIN and CYTOPLASMIC TAIL

 

Human ATRN           YYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWAASFSAGTQAGEEMPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFV

Human ATRNL1         YYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGSTAGTISGEETSIVSKNNIKEYRDSFSYEKFNFRSNPNITFYV

 

Human ATRN           YVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKP

Human ATRNL1         YVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKP

 

Human ATRN           IALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEK-SGAVRNRKQQPPAQPGTCI

Human ATRNL1         IAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDKTSG-VRNRK-HLSTRQGTCV

 

TRANSMEMBRANE REGION

 

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This page last updated:	Thursday, 09 March 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk