Group XII - CTLD with acidic neck

Joint human/mouse sequence alignment

Human sequence alignment

Introduction

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SIGNAL SEQUENCE and ACIDIC DOMAIN

 

human EMBP   MKLPLLLA-LLFGAVSALHLRSETSTFETPLGAKTLPEDEETP-EQEMEETPC----RELEEEEEWGSGSEDASKKDGAVESISVPDMVDKNL

mouse EMBP   MKFPLLLA-LLVGGASALHLSSETSDSKSPLMDENLPRDAEIS-GPEGEECPPGEELMPLEGEKEEGSGSEGVPGDEGAVSGQDVTDVDL

human EMBPH  MQRLLLLPFLLLGTVSALHLENDAPHLESLETQADLGQDLDSSKEQERDLALTEEVIQA-EGEEVKASACQDNFEDEEAMESDPAALDKDF

mouse EMBPH  MKQPLILSFLLLGMVSAFHLE--TAHLENPKREESLKQEADGSREQGRELALTQETKQT-EGEEVEGSQHQDIFEDEEAMESDPDALNKDS

 

SIGNAL SEQUENCE     ACIDIC RESIDUES

CTLD

 

human EMBP     TCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQAWFTCRR--CYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSG->

mouse EMBP     QCPKEEDTTSLMGDSGCKTCRYLLVRRAECFDKAQSVCRR--CYRGTLASIHSFSVNFGIQSAVRGINQGQVWIGGRIKGWG->

human EMBPH    QCPREEDIVEVQGSPRCKTCRYLLVRTPKTFAEAQNVCSR--CYGGNLVSIHDFNFNYRIQCCTSTVNQAQVWIGGNLRGWF->

mouse EMBPH    ACPKEEDTTHFQGTPGCKSCNYVLVRTPETFDKAQRVCRR--CYRGNLASVHSYSFNYQIQNLARKINQSIVWIGGILRGWF->

 

human EMBP     ------------RCRRFQWVDGSR-WNFAYWAAHQPWSRGG----HCVALCTRGGYWRRAHCLRRLPFICSY

mouse EMBP     ------------RCKRFRWVDGSS-WNFAYWAAGQPCPGGG----RCVTLCTQGGHWRLSHCVKRRPFICSY

human EMBPH    --------LWKRFCWTDGSH-----WNFAYWSPGQPGNGQG----SCVALCTKGGYWRRAQCDKQLPFVCSF

mouse EMBPH    ---------WKKFCWMDGSC-----WDFGYWAPGQPGSGGG----HCVTLCTKGGHWRRASCKSHLPFICSF

CONSERVED CORE RESIDUES    Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

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SIGNAL SEQUENCE

 

human DCL-1 MLRAALPALLLPLLGLAAAAV

mouse DCL-1 MPHAALSSLV--LLSLATAIV

 

CTLD

 

human DCL-1 ADCPSSTWIQFQDSCYIFLQEAIKVESIEDVRNQCTDHGADMISIHNEEENAFILDTLKKQWKGPDDILLGMFYDTDD

mouse DCL-1 ADCPSSTWVQFQGSCYAFLQVTINVENIEDVRKQCTDHGADMVSIHNEEENAFILDTLQKRWKGPDDLLLGMFYDTDD

human DCL-1 ASFKWFDNSNMTFDKWTDQDDDEDLVDTCAFLHIKTGEWKKGNCEVSSVEGTLCKTAIPYKRKYLSDNH

mouse DCL-1 -TFKWYDHSNMTFDKWADQD-GEDLVDTCGFLYTKTGEWRKGDCEISSVEGTLCKAA---------NNH

 

TRANSMEMBRANE REGION and CYTOPLASMIC TAIL

 

human DCL-1 ILISALVIASTVILTVLGAIIWFLYKKHSDSRFTTVFSTAPQSPYNEDCVLVVGEENEYPVQFD

mouse DCL-1 ILISTLVIASTVTLAVLGAIIWFLYRRNARSGFT-SFSPAPLSPYSDGCALVVAEEDEYAVQLD

TRANSMEMBRANE DOMAIN

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This page last updated:	Thursday, 09 March 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk