Group XIV - Endosialin family

Human sequence alignment

Joint human/mouse sequence alignment

Introduction

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SIGNAL SEQUENCE

   

Endosialin        MLLRLLLAWAAAGPTLG

Thrombo.          MLGVLVLGALALAGLGFPAPA

C1qRp             MATSMGLLLLLLLLLTQPGAG

Clec14A           MRPAFALCLLWQALWPGPGGG

CTLD

Endosialin        QDPWAAEPRAAC-GPSSCYALFPRRRT----FLEAWRACRELGGDLATPRTPEEAQRVDSLV--------GAGPASRLLWIGLQRQARQCQLQR---PLRG

Thrombo.             EPQPGGSQC-VEHDCFALYPGPAT----FLNASQICDGLRGHLMTVRSSVAADVISLLL----NGDGGVG--RRRLWIGLQLPPG-CGDPKRLGPLRG

C1qRp               TGADTEAVVC-VGTACYTAHSGKLS----AAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPS-L-PLKG

Clec14A             EHPTADRAGCSASGACYSLHHATMK----RQAAEEACILRGGALSTVRAGAELRAVLALLRAGPGP--GGGSKDLLFWVALERRRSHCTLENE--PLRG

 

Endosialin        FTWTTGDQ---DTAFTNWAQPASGG-----PCPAQRCVALE--------ASGEHRWLEGSCTLA------VDGYLCQF

Thrombo.          FQWVTGDN---NTSYSRWARLDLNG---APLCG-PLCVAVS---AAEATVPSEPIWEEQQCEVK------ADGFLCEF

C1qRp             FSWVGGGE---DTPYSNWHKELRNS------CISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVCKF

Clec14A           FSWLSSDPGGLESDTLQWV-EEPQR-----SCTARRCAVLQ-----ATGGVEPAGWKEMRCHLR------ANGYLCKY

 

CONSERVED CORE RESIDUES    Ca SITE 1 RESIDUES    POTENTIAL Ca SITE 2 RESIDUES

SUSHI-LIKE DOMAIN

 

Endosialin        GFEGACPALQDEAGQAGPA----VYTTPFHLVSTEFEWLPFGSVAAVQCQAG-----RGASLLCVKQPEGGVGWSRAGPLCLGTG

Thrombo.          HFPATCRPLAVEP-GAAAAAVSITYGTPFAARGADFQALPVGSSAAVA--------PLGLQLMCTAPPGAVQGHWAREAPGA

C1qRp             SFKGMCRPLALGGPGQ------VTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPK

Clec14A           QFEVLCPAPRPGAASN------LSYRAPFQLHSAALDFSPPGTEVSALC-----RGQLPISVTCIADEIGARWDKLSGDVLCPC

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EGF DOMAINS

 

Endosialin EGF1   --CSPDNGG-CE--HECVE--EVDGHVSCRCTEGFRLAADGR-SCE----

Endosialin EGF2   DPCAQ--AP-CE--QQCEP--GGPQGYSCHCRLGFRPAEDDPHRCVDT--

Endosialin EGF3   DECQI--AGVCQ--QMCV---NYVGGFECYCSEGHELEADG-ISCSPAG-

 

Thrombo.   EGF1   WDCSVENGG-CE--HACN---AIPGAPRCQCPAGAALQADGR-SCTASAT

Thrombo.   EGF2   QSCND----LCE--HFCVPNPDQPGSYSCMCETGYRLAADQ-HRCEDV--

Thrombo.   EGF3   DDCILEPSP-CP--QRCV---NTQGGFECHCYPNYDLVDG---ECVEPV-

Thrombo.   EGF4   DPCFR--AN-CE--YQCQP--LNQTSYLCVCAEGFAPIPHEPHRCQ----

Thrombo.   EGF5   MFCNQ--T-ACP--ADCD---P-NTQASCECPEGYILDDG--FICTDI--

Thrombo.   EGF6   DECEN--GGFCS--GVCH---NLPGTFECICGPDSALARHIGTDCD----

 

C1qRp      EGF1   YGCNFNNGG-CH--QDCFE--GGDGSFLCGCRPGFRLLDDL-VTCASR--

C1qRp      EGF2   NPCSS--SP-CRGGATCVLG-PHGKNYTCRCPQGYQLDSSQ-LDCVDV--

C1qRp      EGF3   DECQD--SP-CA--QECV---NTPGGFRCECWVGYEPGGPGEGACQDV--

C1qRp      EGF4   DECALGRSP-CA--QGCT---NTDGSFHCSCEEGYVLAGEDGTQCQDV--

C1qRp      EGF5   DECVGPGGPLCD--SLCF---NTQGSFHCGCLPGWVLAPNG-VSC-----

 

Clec14A    EGF1   -PGRYLRAGKCAELPNCL---DDLGGFACECATGFEL-GKDGRSCV----

 

CONSERVED RESIDUES

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PROLINE/SERINE/THREONINE-RICH DOMAIN

 

Endosialin    AMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWME

              PTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSR----------------DHQIPVIAANY

              PDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTT

              SRSPVSPAHQISVPAATQPAALPTL-LPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQ

 

Thrombo.      TGKVDGGDTGTGEPPPTPTPGTTLTPPAV

 

C1qRp         TMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGT

 

Clec14A       TSGEGQPTLGGTGVPTRRPPATATSPVPQRTWPIRVDEKLGETPLVPEQDNSVTSIPEIPRWGSQSTMSTLQMSLQAESKATITPSGSVISKFNSTTSSATPQAFDSSSA

TRANSMEMBRANE DOMAIN and CYTOPLASMIC TAIL

 

Endosialin       RDDRWLLV--ALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV

Thrombo.         GLVHSGLL-IGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL

C1qRp             DGQKLLLFYILGTVVAILLLLALALGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC

Clec14A               VVFIFVSTAVVVLVILTMTVLGLVKLCFHESPSSQPRKESMGPPGLESDPEPAALGSSSAHCTNNGVKVGDCDLRDRAEGALLAESPLGSSDA

TRANSMEMBRANE DOMAIN

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This page last updated:	Thursday, 09 March 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk