Group XIV - Endosialin family
- Joint human/mouse sequence alignment
|
Mammalian
proteins containing CTLDs
|
If alignments appear scrambled please maximize the width of your browser
window.
-
-
- SIGNAL SEQUENCE
-
- Human Endosialin
MLLRLLLAWAAAGPTLGQDP
-
Mouse
Endosialin
MLLRLLLAWVAAVPALGQVP
-
Human Thrombo.
MLGVLVLGALALAGLGFPAPA
-
Mouse
Thrombo.
MLGIFFLGVLAPASLGLSAA
-
Human C1qRp
MATSMGLLLLLLLLLTQPGAGT
-
Mouse C1qRp
MAISTGLFLLLG-LLGQPWAGA
-
Human Clec14A MRPAFALCLLWQALWPGPGGGE
-
Mouse Clec14A MRPALALCLLCPAFWPRPGNGE
CTLD
- Human
Endosialin WAAEPRAAC-GPSSCYALFPRRRT----FLEAWRACRELGGDLATPRTPEEAQRVDSLV--------GAGPASRLLWIGLQRQARQCQLQR---
- Mouse
Endosialin WTPEPRAAC-GPSSCYALFPRRRT----FLEAWRACRELGGNLATPRTPEEAQRVDSLV--------GVGPANGLLWIGLQRQARQCQPQR---
- Human
Thrombo.
EPQPGGSQC-VEHDCFALYPGPAT----FLNASQICDGLRGHLMTVRSSVAADVISLLL----NGDGGVG--RRRLWIGLQLPPG-CGDPKRLG
- Mouse
Thrombo.
KLQPTGSQC-VEHECFALFQGPAT----FLDASQACQRLQGHLMTVRSSVAADVISLLLSQSSM--------DLGPWIGLQLPQG-CDDPVHLG
- Human
C1qRp
GADTEAVVC-VGTACYTAHSGKLS----AAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPS-L-
- Mouse C1qRp
AADSQAVVC-EGTACYTAHWGKLS----AAEAQHRCNENGGNLATVKSEEEARHVQQALTQLLKTKAPLEAKMGKFWIGLQREKGNCTYHD-L-
-
Human Clec14A HPTADRAGCSASGACYSLHHATMK----RQAAEEACILRGGALSTVRAGAELRAVLALLRAGPGP--GGGSKDLLFWVALERRRSHCTLENE--
-
Mouse Clec14A HPTADRAACSASGACYSLHHATFK----RRAAEEACSLRGGTLSTVHSGSEFQAVLLLLRAGPGP--GGGSKDLLFWVALERSISQCTQEKE--
-
- Human
Endosialin
PLRGFTWTTGDQ---DTAFTNWAQPASGG-----PCPAQRCVALE--------ASGEHRWLEGSCTLA------VDGYLCQF
- Mouse
Endosialin
PLRGFIWTTGDQ---DTAFTNWAQPATEG-----PCPAQRCAALE--------ASGEHRWLEGSCTLA------VDGYLCQF
- Human
Thrombo.
PLRGFQWVTGDN---NTSYSRWARLDLNG---APLCG-PLCVAVS---AAEATVPSEPIWEEQQCEVK------ADGFLCEF
- Mouse
Thrombo.
PLRGFQWVTGDN---HTSYSRWARPNDQT---APLCG-PLCVTVS---TATEAAPGEPAWEEKPCETE------TQGFLCEF
- Human
C1qRp
PLKGFSWVGGGE---DTPYSNWHKELRNS------CISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVCKF
- Mouse C1qRp
PMRGFSWVGGGE---DTAYSNWYKASKSS------CIFKRCVSLILDLSLTPHPSHLPKWHESPCGTPEAPGNSIEGFLCKF
- Human Clec14A
PLRGFSWLSSDPGGLESDTLQWV-EEPQR-----SCTARRCAVLQ-----ATGGVEPAGWKEMRCHLR------ANGYLCKY
- Mouse Clec14A
PLRGFSWLHPDSEDSEDSPLPWV-EEPQR-----SCTVRKCAALQ-----ATRGVEPAGWKEMRCHLR------TDGYLCKY
-
- CONSERVED
CORE RESIDUES
Ca SITE 1 RESIDUES POTENTIAL Ca SITE 2 RESIDUES
- SUSHI-LIKE DOMAIN
-
- Human Endosialin
GFEGACPALQDEAGQAGPA----VYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLL-----CVKQPEGGVGWSRAGPLCLGTG
-
Mouse
Endosialin GFEGACPALPLEVGQAGPA----VYTTPFNLVSSEFEWLPFGSVAAVQCQAGRGASLL-----CVKQPSGGVGWSQTGPLCPGTG
- Human Thrombo. HFPATCRPLAVEPG-AAAAAVSITYGTPFAARGADFQALPVGSSAAVA---PLGLQLMCTAPPGAVQGHWAREAPGA
- Mouse
Thrombo. YFTASCRPLTVNTRDPEAAHISSTYNTPFGVSGADFQTLPVGSSAAVE---PLGLELVCRAPPGTSEGHWAWEATGA
- Human C1qRp
SFKGMCRPLALGGPGQ------VTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPK
- Mouse
C1qRp
NFKGMCRPLALGGPGR------VTYTTPFQATTSSLEAVPFASVANVACGDEAKSE--THYFLCNEKTPGIFHWGSSGPLCVSPK
- Human Clec14A QFEVLCPAPRPGAASN------LSYRAPFQLHSAALDFSPPGTEVSALCRGQLPISVTCIADEIGARWDKL-SGDVLCPC
- Mouse Clec14A
QFEVLCPAPRPGAASN------LSFQAPFRLSSSALDFSPPGTEVSAMCPGDLSVSSTCIQEETSAHWDGLFPGTVLCPC
Back to
top
- EGF DOMAINS
-
- Human Endosialin
EGF1 --CSPDNGG-CE--HECVE--EVDGHVSCRCTEGFRLAADGR-SCE----
- Mouse Endosialin EGF1 --CGPDNGG-CE--HECVE--EVDGAVSCRCSEGFRLAADGH-SCE----
- Human Endosialin
EGF2 DPCAQ--AP-CE--QQCEP--GGPQGYSCHCRLGFRPAEDDPHRCVDT--
- Mouse
Endosialin EGF2 DPCAQ--AP-CE--QQCEP--GGPQGYSCHCRLGFRPAEDDPHRCVDT--
- Human
Endosialin EGF3 DECQI--AGVCQ--QMCV---NYVGGFECYCSEGHELEADG-ISCSPAG-
- Mouse
Endosialin EGF3 DECQI--AGVCQ--QMCV---NYVGGFECYCSEGHELEADG-ISCSPAG-
-
- Human
Thrombo. EGF1 WDCSVENGG-CE--HACN---AIPGAPRCQCPAGAALQADGR-SCTASAT
- Mouse
Thrombo. EGF1 WNCSVENGG-CE--YLCN---RSTNEPRCLCPRDMDLQADGR-SCARPVV
- Human
Thrombo. EGF2 QSCND----LCE--HFCVPNPDQPGSYSCMCETGYRLAADQ-HRCEDV--
- Mouse
Thrombo. EGF2 QSCNE----LCE--HFCVSNAEVPGSYSCMCETGYQLAADG-HRCEDV--
- Human
Thrombo. EGF3 DDCILEPSP-CP--QRCV---NTQGGFECHCYPNYDLVDG---ECVEPV-
- Mouse
Thrombo. EGF3 DDCKQGPNP-CP--QLCV---NTKGGFECFCYDGYELVDG---ECVELL-
- Human
Thrombo. EGF4 DPCFR--AN-CE--YQCQP--LNQTSYLCVCAEGFAPIPHEPHRCQ----
- Mouse
Thrombo. EGF4 DPCFG--SN-CE--FQCQP--VSPTDYRCICAPGFAPKPDEPHKCE----
- Human
Thrombo. EGF5 MFCNQ--T-ACP--ADCD---P-NTQASCECPEGYILDDG--FICTDI--
- Mouse
Thrombo. EGF5 MFCNE--T-SCP--ADCD---P-NSPTVCECPEGFILDEG--SVCTDI--
- Human
Thrombo. EGF6 DECEN--GGFCS--GVCH---NLPGTFECICGPDSALARHIGTDCD----
- Mouse
Thrombo. EGF6 DECSQ--GE-CFT-SECR---NFPGSYECICGPDTALAGQISKDCD----
-
- Human
C1qRp EGF1 YGCNFNNGG-CH--QDCFE--GGDGSFLCGCRPGFRLLDDL-VTCASR--
- Mouse
C1qRp EGF1 FGCSFNNGG-CQ--QDCFE--GGDGSFRCGCRPGFRLLDDL-VTCASR--
- Human
C1qRp EGF2 NPCSS--SP-CRGGATCVLG-PHGKNYTCRCPQGYQLDSSQ-LDCVDV--
- Mouse
C1qRp EGF2 NPCSS--NP-CTGGGMCHSV-PLSENYTCRCPSGYQLDSSQ-VHCVDI--
- Human
C1qRp EGF3 DECQD--SP-CA--QECV---NTPGGFRCECWVGYEPGGPGEGACQDV--
- Mouse
C1qRp EGF3 DECQD--SP-CA--QDCV---NTLGSFHCECWVGYQPSGPKEEACEDV--
- Human
C1qRp EGF4 DECALGRSP-CA--QGCT---NTDGSFHCSCEEGYVLAGEDGTQCQDV--
- Mouse
C1qRp EGF4 DECAAANSP-CA--QGCI---NTDGSFYCSCKEGYIVSGEDSTQCEDI--
- Human
C1qRp EGF5 DECVGPGGPLCD--SLCF---NTQGSFHCGCLPGWVLAPNG-VSC-----
- Mouse
C1qRp EGF5 DECSDARGNPCD--SLCF---NTDGSFRCGCPPGWELAPNG-VFC-----
-
- Human Clec14A EGF1 -PGRYLRAGKCAELPNCL---DDLGGFACECATGFEL-GKDGRSCV----
- Mouse
Clec14A EGF1 -SGRYLLAGKCVELPDCL---DHLGDFTCECAVGFEL-GKDGRSCE----
-
- CONSERVED
RESIDUES
Back to top
-
PROLINE/SERINE/THREONINE-RICH DOMAIN
-
- Human
Endosialin AMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWME
- Mouse
Endosialin AMGAQASQDLRDELLDDGEEGEDEEEPWEDFDGTWTEEQGILWLA
-
- Human
Endosialin
PTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSR----------------DHQIPVIAANY
- Mouse
Endosialin
PTHPPDFGLPYRPNFPQDGEPQRLHLEPTWPPPLSAPRGPYHSSVVSATRPMVISATRPTLPSAHKTSVISATRPPLSPVHPPAMAPATPPAVFSEHQIPKIKANY
-
- Human
Endosialin
PDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTT
- Mouse
Endosialin PDLPFGHKPGITSATHPARPPPYQPPIISTNYPQVFPPHQAPMSPDT-----HTITYLPPVPPHLDPGDTTSKAHQHPLLPDAPGIRTQAPQLSV-SALQPPLPTN
-
- Human
Endosialin
SRSPVSPAHQISVPAATQPAALPTL-LPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQ
- Mouse
Endosialin SRSSV---HETPVPAANQPPAFPSSPLPPQRPTNQTSSISPTHSYSRAPLVPREGVPSPKSVPQLPSVPSTAAPTALAESGLAGQSQ
-
-
- Human Thrombo.
TGKVDGGDTGTGEPPPTPTPGTTLTPPAV
- Mouse
Thrombo. PIPVREDTKEEEGSGEPPVSPTPGSPTGPPS
-
- Human C1qRp
TMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGT
- Mouse C1qRp
SRGTVFSELPARPPQKEDNDDRKESTMPPTEMPSSPSGSKDVSNRAQTTGLFVQSDIPTASVPLEIEIPSEVSDVWFELGTYLPTTSGHSKPTHEDSVSAHSDT
-
- Human Clec14A
TSGEGQPTLGGTGVPTRRPPATATSPVPQRTWPIRVDEKLGETPLVPEQDNSVTSIPEIPRWGSQSTMSTLQMSLQAESKATITPSGSVISKFNSTTSSATPQAFDSSSA
-
Mouse Clec14A
TKVEEQLTLEGTKLPTRNVTATPAGAVTNRTWPGQVYDKPGEMPQVTEIL----------QWGTQSTLPTIQKTPQTKPKVTGTPSGSVV--LNYTSSPPVSLTFDTSST
- TRANSMEMBRANE REGION and
CYTOPLASMIC TAIL
-
- Human Endosialin
RDDRWLLV--ALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV
- Mouse
Endosialin RDDRWLLV--ALLVPTCVFLVVLLALGIVYCTRCGSHAPNKRITDCYRWVTHAGNKSSTEPMPPRGSLTGVQTCRTSV
- Human
Thrombo.
GLVHSGLL-IGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
- Mouse
Thrombo. ARPVHSGVLIGISIASLSLVVALLALLCHLRKKQGAARAELEYKCASSAKEVVLQHVRTDRTLQKF
- Human C1qRp
DGQKLLLFYILGTVVAILLLLALALGLLVYRKRRAKREEKKEKKPQNAADSYSWVPERAESRAMENQYSPTPGTDC
- Mouse
C1qRp
DGQNLLLFYILGTVVAISLLLVLALGILIYHKRRAKKEEIKEKKPQNAADSYSWVPERAESQAPENQYSPTPGTDC
- Human Clec14A
VVFIFVSTAVVVLVILTMTVLGLVKLCFHESPSSQPRKESMGPPGLESDPEPAALGSSSAHCTNNGVKVGDCDLRDRAEGALLAESPLGSSDA
-
Mouse Clec14A
VVFILVSIAVIVLVVLTITVLGLFKLCFHKSRSSRTGKGALDSPGVECDAEATSLHHSSTQCTDIGVKSGTVA
-
- TRANSMEMBRANE REGION
-
-
Back to top
_______________________________________________________________________________________________________________________________
- This page last updated:
|
-
Thursday, 09 March 2006
|
-
Animal
lectins home
|
| Contact information: |
This site is
supported by: |
-
- Kurt Drickamer
- Division of Molecular Biosciences
- Faculty of Natural Sciences
- Imperial College London
-
- Email:
k.drickamer@imperial.ac.uk
|
-
-
|
 |
 |