Group XI - Attractin family

Joint human/mouse sequence alignment

Human sequence alignment

Introduction

N-TERMINAL REGION

 

Human ATRN           M--VAAAAATEARLRRRTAATAALAGRSGGPHWDWDVTRAGRPGLGAGLRLPRLLSPPLRPRLLLLLLLLSPPLLLLLLPCEAEAAAAAAAVSGSAAAEAKE

Mouse ATRN           MVAVAAAAATEARLRGSTTTTAAPAGRKGRQHRPCTATGAWRPGPRARLCLPRVLSRALPPP-PLLPLLFS--LLLLPLPREAEAAAVAAAVSGSAAAEAKE

Human ATRNL1         METGGRARTGTPQPAAPGVWRARPAGGGGGGASSW-----------------------------------LLDGNSWLLCYGFLYLALYAQVSQS-----KP

Mouse ATRNL1         MEPGVRARSGAPQPASPVLWRARPAGGGG--ASSW----------------------------------LLLDGNSWLLCYGSLYLALYAQVSQS-----KP    

 

SIGNAL SEQUENCE

 

 

 

EGF DOMAIN

 

Human ATRN   EGF1    CDRP--CVNGGRCNPGTGQCVC-PAGWVGEQC

Mouse ATRN   EGF1    CDRP--CVNGGRCNPGTGQCVC-PTGWVGEQC

Human ATRNL1 EGF1    CERTGSCFSG-RCVNST--CLCDP-GWVGDQC

Mouse ATRNL1 EGF1    CERTGSCFSG-RCVNST--CLCDP-GWVGDQC

 

CONSERVED RESIDUES

 

 

 

CUB DOMAIN

 

Human ATRN           QHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYAPLVAAFSGLIVPERDGNETVPEVVATSGYALLHFFSDAAYNLTGFNITYSFDM

Mouse ATRN           QHCGGRFRLTGSSGFVTDGPGNYKYKTKCTWLIEGQPNRIMRLRFNHFATECSWDHLYVYDGDSIYAPLIAAFSGLIVPERDGNETAPEVTVTSGYALLHFFSDAAYNLTGFNITYNFDM

Human ATRNL1         QHCQGRFKLTEPSGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLIAVLSGLIVPEIRGNETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINS

Mouse ATRNL1         QHCQGRFKLTEPSGYLTDGPINYKYKTKCTWLIEGYPNAVLRLRFNHFATECSWDHMYVYDGDSIYAPLVAVLSGLIVPEVRGNETVPEVVTTSGYALLHFFSDAAYNLTGFNIFYSINS

 

CONSERVED RESIDUES

 

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EGF DOMAINS

Human ATRN   EGF2    CPNNCSG--RGECKISNSS-DTVECECSENWKGEACDIPH

Mouse ATRN   EGF2    CPNNCSG--RGECKSSNSS-SAVECECSENWKGESCDIPH

Human ATRNL1 EGF2    CPNNCSG--HGKCTTSVSVPSQVYCECDKYWKGEACDIPY

Mouse ATRNL1 EGF2    CPNNCSG--HGKCTTSVSVASQVYCECDKYWKGEACDIPY

 

Human ATRN   EGF3    CTDNCGFPHRGICNSSDVRG----CSCFSDWQGPGCSVPVPANQSFWTREEYSNLKLP

Mouse ATRN   EGF3    CTDNCGFPHRGICNASDTRG----CSCFPHWQGPGCSIPVPANQSFWTREEYSDLKLP

Human ATRNL1 EGF3    CKANCGSPDHGYCDLTGEKL----CVCNDSWQGPDCSLNVPSTESYWILPNVKPFSPSVG

Mouse ATRNL1 EGF3    CKANCGSPDHGYCDLTGEKL----CVCNDSWQGPDCSLNVPSTESYWILPNVKPFSPSVG

 

CONSERVED RESIDUES

 

 

 

KELCH REPEATS

 

Human ATRN   KELCH1  RASHKAVVNG--NIMWVVGGYMFNHSDYNMVLAYDLASREWLPLNRSVNNVVV  

Mouse ATRN   KELCH1  RASHKAVVNG--NIMWVVGGYMFNHSDYSMVLAYDLTSREWLPLNHSVNSVVV

Human ATRNL1 KELCH1  RASHKAVLHG--KFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGTPSRGPLQ-

Mouse ATRNL1 KELCH1  RASHKAVLHG--KFMWVIGGYTFNYSSFQMVLNYNLESSIWNVGAVSRGPLQ-

 

Human ATRN   KELCH2  RYGHSLALYK--DKIYMYGGKIDST-GNVTNELRVFHIHNESWVLLTP---KAKEQYAVVGHSAHIVTLKNGRVVMLVIFGHCPLYGYISNVQEYDLDKNTWSILHTQGALVQG  

Mouse ATRN   KELCH2  RYGHSLALHK--DKIYMYGGKIDST-GNVTNELRVFHIHNESWVLLTP---KAKDQYAVVGHSAHIVTLASGRVVMLVIFGHCPLYGYISVVQEYDLEKNTWSILHTQGALVQG

Human ATRNL1 KELCH2  RYGHSLALYQ--ENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQG

Mouse ATRNL1 KELCH2  RYGHSLALYQ--ENIFMYGGRMETSDGNVTDELWVFNVRSQSWSTKTPTVLGHSQQYAVEGHSAHIMELDSRDVVMIVIFGYSAIYGYTSSIQEYHISSNTWLVPETKGAIVQG

 

Human ATRN   KELCH3  GYGHSSVYDHRTRALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFF

Mouse ATRN   KELCH3  GYGHSSVYDDRTKALYVHGGYKAFSANKYRLADDLYRYDVDTQMWTILKDSRFF

Human ATRNL1 KELCH3  GYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFA

Mouse ATRNL1 KELCH3  GYGHTSVYDEVTKSIYVHGGYKALPGNKYGLVDDLYKYEVNTRTWTILKESGFA

 

Human ATRN   KELCH4  RYLHTAVIVS--GTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPDLHHDVN

Mouse ATRN   KELCH4  RYLHTAVIVS--GTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPELHHDVN

Human ATRNL1 KELCH4  RYLHSAVLIN--GAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLHRDVN

Mouse ATRNL1 KELCH4  RYLHSAVLIN--GAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKTLPKPNLHRDVN

 

Human ATRN   KELCH5  RFGHSAVLHN--STMYVFGGFNSLLLSDILVFTSEQCDAHRSEAACLAAGPGIRCVWNTGSSQCISWALATDEQEEKLKSECFSKRTLDHD-  

Mouse ATRN   KELCH5  RFGHSAVLYN--STMYVFGGFNSLLLSDVLVFTSEQCDAHRSEAACVAAGPGIRCLWDTQSSRCTSWELATEEQAEKLKSECFSKRTLDHD-

Human ATRNL1 KELCH5  RFGHSAVVIN--GSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELCKNAGPGIKCVWNKN--HCESWESGNTNNILRAK--CPPK-TAASDD

Mouse ATRNL1 KELCH5  RFGHSAVVIN--GSMYIFGGFSSVLLNDILVYKPPNCKAFRDEELCRNAGPGIKCVWNKN--HCESWESGNTNNILRAK--CPPK-TAATDD

 

CONSERVED RESIDUES

 

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CYSTEINE-RICH REPEATS - #1

 

Human ATRN   PLEX 1  RCDQHTDCYSCTANTNDCHWC--NDHCVPRNHSCSEGQISIFRYENCPKDNPMYY

Mouse ATRN   PLEX 1  RCDQHTDCYSCTANTNDCHWC--NDHCVPVNHSCTEGQISIAKYESCPKDNPMYY

Human ATRNL1 PLEX 1  RCYRYADCASCTANTNGCQWCD-DKKCISANSNCS---MSVKNYTKCHVRNEQI-

Mouse ATRNL1 PLEX 1  RCYRYADCASCTANTNGCQWCD-DKKCISASSNCS---TSVRNYTKCHIRNEQI-

 

Human ATRN   PLEX 2  -CNKKTSCRSCALDQN-CQWEPRNQECI-ALPENICGIGWHLVGNSCLKITTA

Mouse ATRN   PLEX 2  -CNKKTSCRSCALDQN-CQWEPRNQECI-ALPENICGNGWHLVGNSCLKITTA

Human ATRNL1 PLEX 2  -CNKLTSCKSCSLNLN-CQWDQRQQECQ-ALPAHLCGEGWSHIGDACLRVNSS

Mouse ATRNL1 PLEX 2  -CNKLTSCKSCSLNLN-CQWDQRQQECQ-ALPAHLCGEGWNHVGDACLRINSS

 

CONSERVED RESIDUES

 

 

 

CTLD

 

Human ATRN           KENYDNAKLFCRNHNALLASLTTQKKVEFVLKQLRIMQSSQSMSKLTLTPWVGLRKINVS

Mouse ATRN           KENYDNAKLSCRNHNAFLASLTSQKKVEFVLKQLRLMQSSQSMSKLTLTPWVGLRKINVS

Human ATRNL1         RENYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKYTQ-Q---K--VSPWVGLRKINIS

Mouse ATRNL1         RESYDNAKLYCYNLSGNLASLTTSKEVEFVLDEIQKFTQ-Q---K--VSPWVGLRKINIS

 

Human ATRN           YWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRT----

Mouse ATRN           YWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCINPLNGSVCERPANHSAKQCRT----

Human ATRNL1         YWGWEDMSPFTNTTLQWLPGEPNDSGFCAYLERAAVAGLKANPCTSMANGLVCEKP-VVSPNQNARPCKK

Mouse ATRNL1         YWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSVAGLKANPCTSMADGLVCEKP-VVSPNQNARPCKK

 

CONSERVED CORE RESIDUES     Ca SITE 1 LIGANDS     Ca SITE 2 LIGANDS (SUGAR-BINDING SITE)

 

CYSTEINE-RICH REPEATS - #2

 

Human ATRN   PLEX 3  PCALRTACGDCTSGSSECMWC---SNM-K-QCVDSNAYVASFPFGQCMEWYTMSTCPPEN

Mouse ATRN   PLEX 3  PCALRTACGECTSSSSECMWC---SNM-K-QCVDSNAYVASFPFGQCMEWYTMSSCPPEN 

Human ATRNL1 PLEX 3  PCSLRTSCSNCTSNGMECMWC---SST-K-RCVDSNAYIISFPYGQCLEWQT-ATCSPQN

Mouse ATRNL1 PLEX 3  PCSLRTSCANCTSSGMECMWC---SST-K-RCVDSNAYIISFPYGQCLEWQT-ATCSPQN

 

Human ATRN   PLEX 4  -CSGYCTCSHCLEQPG-CGWCTDPSNTGKGKCIEGSYKGPVKMPSQAPTGNFYPQPLLNSSMCLEDSRYNWSFIHCPACQ

Mouse ATRN   PLEX 4  -CSGYCTCSHCLEQPG-CGWCTDPSNTGKGKCIEGSYKGPVKMPSQASAGNVYPQPLLNSSMCLEDSRYNWSFIHCPACQ   

Human ATRNL1 PLEX 4  -CSGLRTCGQCLEQPG-CGWCNDPSNTGRGHCIEGSSRGPMKL-----IGMHHNEMVLDTNLCPKEKNYEWSFIQCPACQ

Mouse ATRNL1 PLEX 4  -CSGLRTCGQCLEQPG-CGWCNDPSNTGRGYCIEGSSRGPMKL-----AGVHNSDVVLDTSLCPKEKNYEWSFIQCPACQ

 

CONSERVED RESIDUES

 

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LAMININ EGF DOMAINS

Human ATRN   EGF1    CNGH-SKCINQSICEKCEN-LTTGKHCETC-ISGFY-GDPTNGGKCQPCK  

Mouse ATRN   EGF1    CNGH-SKCINQSICEKCED-LTTGKHCETC-ISGFY-GDPTNGGKCQPCK

Human ATRNL1 EGF1    CNGH-STCINNNVCEQCKN-LTTGKQCQDC-MPGYY-GDPTNGGQCTACT  

Mouse ATRNL1 EGF1    CNGH-STCINNNVCEQCKN-LTTGRQCQEC-MPGYY-GDPTNGGQCTACT

 

Human ATRN   EGF2    CNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLRG-TC  

Mouse ATRN   EGF2    CNGHASLCNTNTGKCFCTTKGVKGDECQLCEVENRYQGNPLKG-TC

Human ATRNL1 EGF2    CSGHANICHLHTGKCFCTTKGIKGDQCQLCDSENRYVGNPLRG-TC  

Mouse ATRNL1 EGF2    CGGHANVCHLHTGKCFCTTKGIKGDQCQLCDSENRYVGNPLRG-TC

 

CONSERVED RESIDUES

 

 

 

C-TERMINAL REGION inc. TRANSMEMBRANE DOMAIN and CYTOPLASMIC TAIL

 

Human ATRN           YYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWAASFSAGTQAGEEMPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFV

Mouse ATRN           YYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASKNFNLNITWATSFPAGTQTGEEVPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFV

Human ATRNL1         YYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGSTAGTISGEETSIVSKNNIKEYRDSFSYEKFNFRSNPNITFYV

Mouse ATRNL1         YYSLLIDYQFTFSLLQEDDRHHTAINFIANPEQSNKNLDISINASNNFNLNITWSVGSTGGTISGEETPIVSKTNIKEYRDSFSYEKFNFRSNPNITFYV

 

Human ATRN           YVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKP

Mouse ATRN           YVSNFTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLLREMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKP

Human ATRNL1         YVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKP

Mouse ATRNL1         YVSNFSWPIKIQIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRERQQMASRPFASVDVALEVGAEQTDFLRGPLEGAPKP

 

Human ATRN           IALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEK-SGAVRNRKQQPPAQPGTCI

Mouse ATRN           IALEPCFGNKAAVLSVFVRLPRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEK-SGAVRNRKQQPPAQPGTCI

Human ATRNL1         IAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDKTSG-VRNRK-HLSTRQGTCV

Mouse ATRNL1         IAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKPSDNKDKTSG-VRNRKHLSTRQ-GTCV

 

TRANSMEMBRANE REGION

 

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This page last updated:	Thursday, 09 March 2006	Animal lectins home
Contact information:	This site is supported by:
Kurt Drickamer Division of Molecular Biosciences Faculty of Natural Sciences Imperial College London   Email: k.drickamer@imperial.ac.uk