Group X - Polycystin
- Joint human/mouse sequence alignment
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Mammalian
proteins containing CTLDs
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window.
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N-TERMINAL REGION inc. SIGNAL SEQUENCE
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Human
MPPAAPARLALALGLGLWLGALAGGPGRGCGPCEPPCLCGPAPGAACRV
- Mouse
MPPGAPALLALALGLGLWLGALAGDPGRGCGPCPLPCFCGPAPDAACRV
SIGNAL SEQUENCE
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LEUCINE-RICH REGION
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Human NCSGRGLRTLGPALRIPADATALDVSHNLLRALDVGLLANLSALAELDISNNKISTLEEGIFANLFNLSEINLSG
- Mouse
NCSGRWLQTLGPSLRIPADATALDLSHNLLQTLDIGLLVNLSALVELDLSNNRISTLEEGVFANLFNLSEINLSG
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Human
NPFECDCGLAWLPRWAEEQQVRVVQPEAATCAGPGSLAGQPLLGIPLLDSGC
- Mouse
NPFECNCGLAWLPRWAKEHQVHVVQSEATTCRGPIPLAGQPLLSIPLLDNAC
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LEUCINE-RICH REPEATS
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WSC DOMAIN and LINKER
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Human WSC
GEEYVACLPDNSSGTVAAVSFSAAHEGLLQPEACSAFCFSTGQGLAALSEQGWCLCGAAQP
- Mouse
WSC
GEEYVACLPDNSSGAVAAVPFYFAHEGPLETEACSAFCFSAGEGLAALSEQNQCLCGAGQA
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Human Link SSASFACLSLCSGPPPPPAPTCRGPTLLQHVFPASPGATLVGPH
- Mouse
Link
SNSSAACSSWCSSISLSLNSACGGPTLLQHTFPASPGATLVGPH
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PKD REPEAT
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Human PKD1 GPLASGQLAAFHIAAPLPVTATRWDFGDGSAEVDAAGPAASHRYVLPGRYHVTAVLALGAGSALLGTDVQVE
Mouse PKD1
GPLASGQPADFHITSSLPISSTRWNFGDGSPEVDMASPAATHFYVLPGSYHMTVVLALGAGSALLETEVQVE
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Human
AAPAALELVCPSSVQSDESLDLSIQNRGGSGLEAAYSIVALGEEPARAVHP
- Mouse
ATPTVLELVCPSFVHSNESLELGIRHRGGSALEVTYSILALDKEPAQVVHP
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CONSERVED RESIDUES
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CTLD
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Human LCPSDTEIFPGNGHCYRLVVEKAAWLQAQEQCQAWAGAALAMVDSPAVQRFLVSRVTRCLDVWIGFSTVQGVE
- Mouse
LCPLDTEIFPGNGHCYRLVAEKAPWLQAQEQCRTWAGAALAMVDSPAIQHFLVSKVTRSLDVWIGFSSVEGTE
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Human VGPAPQGEAFSLESCQNWLPGEPHPATAEHCVRLGPTGWCNTDLCSAPHSYVCE
- Mouse
-GLDPRGEAFSLESCQNWLPGEPHPATAEHCVRLGPAGQCNTDLCSAPHSYVCE
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CONSERVED CORE RESIDUES
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LINKER
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Human
LQPGGPVQDAENLLVGAPSGDLQGPLTPLAQQDGLSAPHEPVEVMVFPGLRLSREAFLTTAEFGTQELRRPAQLRLQVYRLLSTAGTPENGSEPESRSPDNR
- Mouse
LRPGGPVWDTENFVMGMSGGGLSGPLHPLAQQETVQGPLRPVEVMVFPGLSPSREAFLTAAEFSTQKLEEPAQMRLQVYRPSGGAAAVPEGSSE----PDNR
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Human TQLAPACMPGGRWCPGANICLPLDASCHPQACANGCTSGPGLPGAPYALWREFLFSVPAGPPAQYSVTLHGQDVLMLPGDLVGLQHDAGPGALLHCSPAPGH
- Mouse
TEPAPKCVPEELWCPGANVCIPFDASCNSHVCINGSVSRLGLSRASYTLWKEFFFSVPAGPPTQYLVTLHSQDVPMLPGDLIGLQHDAGPGTLLQCPLASSC
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Human
PGPRAPYLSANASSWLPHLPAQLEGTWACPACALRLLAATEQLTVLLGLRPNPGLRLPGRYEVRAEVGNGVSRHNLSCSFDVVSPVAGLRVIYPAPRDGRLY
- Mouse
PG-QALYLSTNASDWMTNLPVHLEEAWAGPVCSLQLLLVTEQLTPLLGLGPNPGLQHPGHYEVRATVGNSVSRQNLSCSFSVVSPIAGLRVIHPIPLDGHIY
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Human VPTNGSALVLQVDSGANATATARWPG
- Mouse
VPTNGSVLVLQVDSGANATATAQWFG
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LDL-RECEPTOR CLASS A
ATYPICAL
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PKD REPEATS
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- Human PKD2
GSVSARFENVCPALVATFVPGCPWETNDTLFSV--------------------------VALPWLSEGEHVVDVVVENSASRANLSLRVTAE
EPICGLRATPSPEA
- Mouse PKD2
GNISAPFEDACPPDVDFLKQDCTEEANGTLFSV--------------------------LMLPRLKEGDHTVEIVAQNGASQANLSLRVTAE
EPICGLRAVPSPEA
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Human PKD3 RVLQGVLVRYSPVVEAGSDMVFRWTINDKQSLTFQNVV---------------------FNVIYQSAAVFKLSLTASNHVSNVTVNYNVTVE
RMNRMQGLQVSTVPAVL
- Mouse PKD3
RVLQGILVRYSPMVEAGSDVAFRWTIDDKQSLTFHNTV---------------------FNVIYQSAAIFKLSLTASNHVSNITVNYNVTVE
RMNKMHGLWVSAVPTVL
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Human PKD4 SPNATLALTAGVLVDSAVEVAFLWTFGDGEQALHQFQPPYNESFPVPDPSVAQVLVEHNVMHTYAAPGEYLLTVLASNAFENLTQQVPVSVR
ASLPSVAVGVSDGV
- Mouse PKD4
PPNATLALTGGVLVDSAVEVAFLWNFGDGEQVLRQFKPPYDESFQVPDPTVAQVLVEHNTTHIYTTPGEYNLTVLVSNTYENLTQQVTVSVR
TVLPNVAIGMSSNV
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Human PKD5 LVAGRPVTFYPHPLPSPGGVLYTWDFGDGSPVLTQSQPA--------------------ANHTYASRGTYHVRLEVNNTVSGAAAQADVRVF
EELRGLSVDM
- Mouse PKD5
LVAGQPITFSPYPLPSTDGVLYTWDFGDGSPVLIQSQPV--------------------LNHTYSMTGTYRITLEVNNTVSSVTAHADIRVF
QELHGLTVYL
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Human PKD6 SLAVEQGAPVVVSAAVQTGDNITWTFDMGDGTVLSGPEAT-------------------VEHVYLRAQNCTVTVGAASPAGHLARSLHVLVF
VLEVLRVEPAAC
- Mouse PKD6
SPSVEQGAPMVVSASVESGDNITWTFDMGDGTVFTGPEAT-------------------VQHVYLRAQNFTVTVEAANPAGHLSQSLHVQVF
VLEVLRIEPSTC
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Human PKD7 IPTQPDARLTAYVTGNPAHYLFDWTFGDGSSNTTVRGCPT-------------------VTHNFTRSGTFPLALVLSSRVNRAHYFTSICVE
PEVGNVTLQPERQ
- Mouse PKD7
IPTQPSAQLMAHVTGDPVHYLFDWTFGDGSSNVTVHGHPS-------------------VTHNFTRSGIFPLALVLSSHVNKAHYFTSICVE
PEIRNITLQPERQ
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Human PKD8 FVQLGDEAWLVACAWPPFPYRYTWDFGTEEAAPTRARGPE-------------------VTFIYRDPGSYLVTVTASNNISAANDSALVEVQ
EPVLVTSIKVNGS
- Mouse PKD8
FVKLGDEARLVAYSWPPFPYRYTWDFGTEDTTHTQTGGSE-------------------VKFIYREPGSYLVIVTVSNNISSTNDSAFVEVQ
EPVLVTGIRINGS
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Human PKD9 LGLELQQPYLFSAVGRGRPASYLWDLGDGGWLEGPE-----------------------VTHAYNSTGDFTVRVAGWNEVSRSEAWLNVTVK
RRVRGLVVNASRT
- Mouse PKD9
HVLELQQPYLLSAMGSGSPATYLWELGDGSQSEGPE-----------------------VTHIYSSTGDFTVRVSGWNEVSRSEAQLNITVK
QRVRGLTINASRT
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Human PKD10 VVPLNGSVSFSTSLEAGSDVRYSWVLCDRCTPIPGGPT---------------------ISYTFRSVGTFNIIVTAENEVGSAQDSIFVYVL
QLIEGLQVVGGGR--
- Mouse PKD10
VVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPT---------------------ISYTFRSVGTFNIIVTAENEVGSAQDSIFIYVL
QFIEGLQVVGGDNGC
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Human PKD11 YFPTNHTVQLQAVVRDGTNVSYSWTAWRDRGPALAGSGKG-------------------FSLTVLEAGTYHVQLRATNMLGSAWADCTMDFV
EPVGWLMVAASPN
- Mouse PKD11
CFPTNYTLQLQAAVRDGTNISYSWTAQQEGSLITLFGSGKC------------------FSLTALKASTYYVHLRATNMLGSAAANRTIDFV
EPVESLILSASPN
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Human PKD12 PAAVNTSVTLSAELAGGSGVVYTWSLEEGLSWETSEPF---------------------TTHSFPTPGLHLVTMTAGNPLGSANATVEVDVQ
VPVSGLSIRASEPG
- Mouse PKD12
PAAVNMSLTLCAELAGGSGVVYTWYLEEGLSWKTSMPS---------------------TTHTFATPGLHLVRVTAENQLGSVNATVEVAIQ
VPVGGLSIRTSEPD
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Human PKD13 GSFVAAGSSVPFWGQLATGTNVSWCWAVPGGSSKRGPH---------------------VTMVFPDAGTFSIRLNASNAVSWVSATYNLTAE
EPIVGLVLWASSK
- Mouse PKD13
SIFVAAGSTLPFWGQLAEGTNVTWCWTLPGGSKDSQYI---------------------AVR-FSTAGSFSLQLNASNAVSWVSAMYNLTVE
EPIVNLMLWASSK
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Human PKD14 VVAPGQLVHFQILLAAGSAVTFRLQVGGANPEVLPGPR---------------------FSHSFPRVGDHVVSVRGKNHVSWAQAQVRIVVL
EAVSGLQVPNCCEP
- Mouse PKD14
VVAPGQPVHFEILLAAGSALTFRLQVGGSVPEVLPSPH---------------------FSHSFFRVGDHLVNVQAENHVSHAQAQVRILVL
EAVVGLQVPNCCEP
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Human PKD15 GIATGTERNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRD----------------VTYTPVAAGLLEIQVRAFNALGSENRTLVLEVQ
DAVQYVALQSGP
- Mouse PKD15
GMATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRD----------------VTYTPVAAGLLEIHVRAFNELGGVNLTLMVEVQ
DIIQYVTLQSGR
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Human PKD16 CFTNRSAQFEAATSPSPRRVAYHWDFGDGSPGQDTDEPR--------------------AEHSYLRPGDYRVQVNASNLVSFFVAQATVTVQ
VLA
- Mouse PKD16
CFTNRSARFEAATSPSPRCVTYHWDFGDGTPVQKTEEFW--------------------ADHYYLRPGDYHVEVNATNLVSFFVAQATVTVQ
VLA
CONSERVED RESIDUES
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REJ DOMAIN
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Human
CREPEVDVVLPLQVLMRRSQRNYLEAHVDLRDCVTYQTEYRWEVYRTASCQRPGRPARVALPGVDVSRPRLVLPRLALPVGHYCFVFVVSFGDTPLTQSIQANV
- Mouse
CREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEIYRTASCQRPGRMAQMVLPGVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANV
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Human
TVAPERLVPIIEGGSYRVWSDTRDLVLDGSESYDPNLEDGDQTPLSFHWACVASTQREAGGCALNFGPRGSSTVTIPRERLAAGVEYTFSLTVWKAGRKEEATN
- Mouse
TVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLEDGDQTPLNFHWACVASTQSETGGCVLNFGPRGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATN
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Human
QTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGRCLNCSSGSKRGRWAARTFSNKTLVLDETTTSTGSAGMRLVLRRGVLRDGEGYTFTLTVLGRSGEE
- Mouse
QTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGHCHNCSRGYKQGCWAARTFSNKTLVLNETTTSTGSTGMNLVVRPGALRDGEGYIFTLTVLGHSGEE
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Human
EGCASIRLSPNRPPLGGSCRLFPLGAVHALTTKVHFECTGWHDAEDAGAPLVYALLLRRCRQGHCEEFCVYKGSLSSYGAVLPPGFRPHFEVGLAVVVQDQLGA
- Mouse
EGCASIRLSPNRPPLGGSCRLFPLDSVRGLTTKVHFECTGWRDAEDGGAPLVYVLLLKRCRQSYCENFCIYKGSLSTYGAVLPPGFQPLFVVSLAVVVQDQLGA
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Human
AVVALNRSLAITLPEPNGSATGLTVWLHGLTASVLPGLLRQADPQHVIEYSLALVTVLNEYERALDVAAEPKHERQHRAQIRKNITETLVSLRVHTVDDIQQIA
- Mouse
AVVALNRSLTIVLPEPSGNPADLVPWLHSLTASVLPGLLKQADPQHVIEYSLALITVLNEYEQAPDVS-EPNVEQQLRAQMRKNITETLISLRVNTVDDIQQIT
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Human
AALAQCMGPSRELVCRSCLKQTLHKLEAMMLILQAETTAGTVTPTAIGDSILNITGDLIHLASSDVRAPQPSELGAESPSRMVASQAYNLTSALMRILMRSRVL
- Mouse
AALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILNITGDLIHLASLDMQGPQPLELGVEPPSLMVASKAYNLSSALMRILMRSRVL
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Human
NEEPLTLAGEEIVAQGKRSDPRSLLCYGGAPGPGCHFSIPEAFSGALANLSDVVQLIFLVDSNP
- Mouse
NEEPLTLAGEEIVALGKRSDPLSLLCYGKALGPSCHFSIPEAFSGALSNLSDVVQLIFLVDSNP
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LINKER
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Human
FPFGYISNYTVSTKVASMAFQTQAGAQIPIERLASERAITVKVPNNSDWAARGHRSSANSANSVVVQPQASVGAVVTLDSSNPAAGLHLQLNYTLLDGHYLSEE
- Mouse
FPFGYISNYTVSTKVASMAFQTQTGTQIPIEQLAAERAITVKVPNNSDQAAQ---SSHNPVGSTIVQPQTSVSAVVTADNSNPQAGLHLRITYTVLNERYLSAE
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Human
PEPYLAVYLHSEPRPNEHNCSASRRIRPESLQGADHRPYTFFISPGSRDPAGSYHLNLSSHFRWSALQVSVGL
- Mouse
PEPYLAVYLHSVSQPNEYNCSASRRISLEVLEGADHRLYTFFIAPGTGTLDRSYYLNLTSHFHWSALEVSVGL
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GPS DOMAIN
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Human
YTSLCQYFSEEDMVWRTEGLLPLEETSPRQAVCLTRHLTAFGASLFVPPS
- Mouse
YTSLCQYFSEEMMMWRTEGIVPLEETSPSQAVCLTRHLTAFGASLFVPPS
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MEMBRANE-SPANNING DOMAIN and
CYTOPLASMIC TAIL
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Human HVRFVFPEPTADVNYIVMLTCAVCLVTYMVMAAILHKLDQLDASRGRAIPFCGQRGRFKYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRAFHRNSLDIFRIATPHSL
- Mouse
HVQFIFPEPSASINYIVLLTCVICLVTYVVMAMILRKLDQLDVSRVRVIPFCGKGGRFKYEILVKTGWSRGSGTTAHVGIMLYGEDNRSGHRHLDGDRAFHRNSLDIFQIATPHSL
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Human
GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWLSVETEANGGLVEKEVLAASDAALLRFRRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRIQRATCCVLLICLFL
- Mouse
GSVWKIRVWHDNKGLSPAWFLQHIIVRDLQSARSTFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRVQRVTCCVLLLCLFL
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Human
GANAVWYGAVGDSAYSTGHVSRLSPLSVDTVAVGLVSSVVVYPVYLAILFLFRMSRSKVAGSPSPTPAGQQVLDIDSCLDSSVLDSSFLTFSGLHAEAFVGQMKSDLFLDDSKSLV
- Mouse
AANAVWYGVVRDTTYSMGPVSSLISPGVDTVAIGLVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPTGQQALDVDSYLDPSVLDSSLLTLSGL-TEAFAGQVKNDLFLEDAKSLV
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Human
CWPSGEGTLSWPDLLSDPSIVGSNLRQLARGQAGHGLGPEEDGFSLASPYSPAKSFSASDEDLIQQVLAEGVSSPAPTQDTHMETDLLSSLSSTPGEKTETLALQRLGELGPPSPG
- Mouse
CWPSSEGTLSWPDLLSDPSVVSSTLQRLTQGRPGCMLGSEEDGASLVSPSLPAKYLSASDEDLIHQVLADGANNLVPTQDTLLETDLLTSLSSVPGEKTETLILQTVGEERPASMG
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Human
LNWEQPQAARLSRTGLVEGLRKRLLPAWCASLAHGLSLLLVAVAVAVSGWVGASFPPGVSVAWLLSSSASFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSA
- Mouse
LSWEQSPVTRLSRTGLVEGFQKRLLPAWCAPLAHGLSLLLVAVAVAVSGWIGASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSE
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Human
RVPRVRPPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGHAYRLQSAIKQELHSRAFLAITRSEELWPWMAHVLLPYVHGNQSSPELGPPRLRQVRLQEA
- Mouse
RVPRVRPPHGFALFLAKEEARKVKRLHDMLKRLLVYMLFLLVTLLANYGDASCHGHAYRLQSAIKQELDSQAFLAITRSDEFWPWMSHVFLPYVHGNQSSPELGPPRLRQVRLQEA
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Human
LYPDPPGPRVHTCSAAGGFSTSDYDVGWESPHNGSGTWAYSAPDLLGAWSWGSCAVYDSGGYVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLEF
- Mouse
FCPDPSSSEHMCSAAGSLSTSDYGIGWQSVVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEF
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Human
PAAGRALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHREGRWRVLRLGAWARWLLVALTAATALVRLAQLGAADRQWTRFVRGRPRRFTSFDQVAQLSSAARG
- Mouse
PVAGHALAAFSVRPFALRRLSTGLSLPLLTSVCLLLFALYFSMAEVQTWRKDGCACTARPDTWARCLLVILTAATGLVRLAQLGIADRQWTHCVQDHPHHFTSFDQVAQLGSVARG
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Human
LAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWSVAQALLVLCPGTGLSTLCPAESWHLSPLLCVGLWALRLWGALRLGAVI
- Mouse
LAASLLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGADTLYNMARAFLVLCPGARVPTLCPSESWYLSPLLCVGLWALRVWGALRLGAIL
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Human
LRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSSRGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTRCEPEPSRLQAVFEA
- Mouse
LRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFSKVKEFRHKVRFEGMDPLPSRSSRGSKSSPVVLPPSSGSEASHPSTSSSQPDGPSASLSRSTLKLEPEPSRLHAVFES
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Human
LLTQFDRLNQATEDVYQLEQQLHSLQGRRSSRAPAGSSRGPSPGLRPALPSRLARASRGVDLATGPSRTPLRAKNKVHPSST
- Mouse
LLVQFDRLNQATEDVYQLEQQLQSLRGHGHNGPPSSPSPGCFPGSQPALPSRLSRASQGLDQTVGPNRVSLWPNNKVHPSST
PREDICTED TRANSMEMBRANE REGIONS
PLAT DOMAIN
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___________________________________________________________________________________________________________
- This page last updated:
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Thursday, 09 March 2006
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Animal
lectins home
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This site is
supported by: |
-
- Kurt Drickamer
- Division of Molecular Biosciences
- Faculty of Natural Sciences
- Imperial College London
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- Email:
k.drickamer@imperial.ac.uk
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