Animal lectins - References

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Calnexin   M-type   L-type   P-type  

Calnexin Family
Parodi, A.J. (2000) Role of N-oligosaccharides endoplasmic reticulum processing reactions in glycoprotein folding and degradation. Biochem. J., 348, 1-13.
Trombetta, E.S. and Helenius, A. (1998) Lectins as chaperones in glycoprotein folding. Cur. Opin. Struct. Biol., 8, 587-592.
Schrag, J.D., Bergeron, J.J., Li, Y., Borisova, S., Hahn, M., Thomas, D.Y., Cygler, M. (2001)  The structure of calnexin, an ER chaperone involved in quality control of protein folding.  Mol. Cell, 8, 633-644.
Thomson, S.P., Williams, D.B. (2005) Delineation of the lectin site of the molecular chaperone calreticulin.  Cell Stress Chaperones, 10, 242-251.
Watanabe, D., Yamada, K., Nishina, Y., Tajima, Y., Koshimizu, U., Nagata, A., Nishimune, Y. (1994)  Molecular cloning of a novel Ca2+-binding protein (calmegin) specifically expressed during meiotic germ cell development.  J. Biol. Chem., 269, 7744-7749.
Ohsako, S., Hayashi, Y., Bunick, D. (1994)  Molecular cloning and sequencing of calnexin-t.  An abundant male germ cell-specific calcium-binding protein of the endoplasmic reticulum.  J. Biol. Chem., 269, 14140-14148.
Tanaka, H., Ikawa, M., Tsuchida, J., Nozaki, M., Suzuki, M., Fujiwara, T., Okabe, M., Nishimune, Y. (1997)  Cloning and characterization of the human calmegin gene encoding putative testis-specific chaperone.  Gene, 204, 156-163.
Ikawa, M., Wada, I., Kominami, K., Watanabe, D., Toshimori, K., Nishimune, Y., Okabe, M. (1997)  The putative chaperone calmegin is required for sperm fertility.  Nature, 387, 607-611.
Persson, S., Rosenquist, M., Sommarin, M. (2002)  Identification of a novel calreticulin isoform (Crt2) in human and mouse.  Gene, 297, 151-158.
Williams, D.B. (2006) Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum.  J. Cell Sci., 119, 615-623.
M-type lectins
Braakman, I. (2001) A novel lectin in the secretory pathway: an elegant mechanism for glycoprotein elimination. EMBO Reports 2, 666-668.
Hosokawa, N., Wada, I., Hasegawa, K., Yorihuzi, T., Tremblay, L.O., Herscovics, A. and Nagata, K. (2001) A novel ER a-mannosidase-like protein accelerates ER-associated degradation. EMBO Reports 2, 415-422.
Jakob, C.A., Bodmer, D., Spirig, U., Battig, P., Marcil, A., Dignard, D., Bergeron, J.J.M., Thomas, D.Y. and Aebi, M. (2001) Htm1p, a mannosidase-like protein, is involved in glycoprotein degradation in yeast. EMBO Reports 2, 423-430.
Nakatsukasa, K., Nishikawa, S., Hosokawa, N., Nagata, K. and Endo, T. (2001) Mnl1p, an a-mannoside-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins. J. Biol. Chem. 276, 8635-8638
Mast, S.W., Diekman, K., Karaveg, K., Davis, A., Sifers, R.N., Moremen, K.W. (2005) Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.  Glycobiology, 15, 421-436.  Erratum: 15, 13G.
Olivari, S., Galli, C., Alanen, H., Ruddock, L., Molinari, M (2005) A novel stress-induced EDEM varient regulating endoplasmic reticulum-associated glycoprotein degradation.  J. Biol. Chem., 280, 2424-2428.
Hirao, K., Natsuka, Y., Tamura, T., Wada, I., Morito, D., Natsuka, S., Romero, P., Sleno, B., Tremblay, L.O., Herscovics, A., Nagata, K., Hosokawa, N. (2006) EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming.  J. Biol. Chem., 218, 9650-9658.
L-type lectins
Sharon, N. and Lis, H. (1990) Legume lectins: a large family of homologous proteins. FASEB J., 4, 3198-3208.
Fiedler, K. and Simons, K. (1994) A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins. Cell, 77, 625-626.
Itin, C., Roche, A.C., Monsigny, M. and Hauri, H.P. (1996) ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins. Mol. Biol. Cell, 7, 483-493.
Rini, J.M. (1995) Lectin structure. Annu. Rev. Biophys. Biomol. Struct., 24, 551-577.
Sharma, V. and Surolia, A. (1997) Analyses of carbohydrate recognition by legume lectins: size of the combining site loops and their primary specificity. J. Mol. Biol., 267, 433-445.Yerushalmi, N., Keppler-Hafkemeyer, A., Vasmatzis, G., Liu, X.F., Olsson, P., Bera, T.K., Duray, P., Lee, B., Pastan, I. (2001) ERGL, a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues.  Gene, 265, 55-60.
Nufer, O., Mitrovic, S., Hauri, H-P. (2003) profile-based data base scanning for manimal L-type lectins and characterization of VIPL, a novel VIP36-like endoplasmic reticulum protein. J. Biol. Chem., 278, 15886-15896.
Kamiya, Y., Yamaguchi, Y., Takahashi, N., Arata, Y., Kasai, K., Ihara, Y., Matsuo, I., Ito, Y., Yamamoto, K., Kato, K. (2005) Sugar-binding properties of VIP36, an intracellular animal lectin operating as a cargo receptor. J. Biol. Chem., 280, 37178-37182.
Satoh, T., Sato, K., Kanoh, A., Yamashita, K., Yamada. Y., Igarashi, N., Kato, R., Nakano, A., Wakatsuki, S. (2006) Structures of the carbohydrate recognition domain of Ca2+-independent cargo receptors Emp46p and Emp47p.  J. Biol. Chem., 281, 10410-10419.
P-type lectins
Dahms, N.M., Lobel, P. and Kornfeld, S. (1989) Mannose 6-phosphate receptors and lysosomal enzyme targeting. J. Biol. Chem., 264, 12115-12118.
Roberts, D.L., Weix, D.J., Dahms, N.M. and Kim, J.-J.P. (1998) Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor. Cell, 93, 639-648.
Munro, S. (2001) The MRH domain suggests a shared ancestry for the mannose 6-phosphate receptors and other N-glycan-recognising proteins. Current Biology, 11, R499-501.
Whyte, J.R.C., Munro, S. (2001) A yeast homologue of the mammalian mannose 6-phosphate rceptors contributes to the sorting of vacuolar hydrolases.  Current Biology, 11, 1074-1078.
Cormier, J.H., Pearse, B.R., Hebert, D.N. (2005) Yos9p: A sweet-toothed bouncer of the secretory pathway.  Mol. Cell, 19, 717-726.
Bhamidipati, A., Denic, V., Quan, E.Q., Weissman, J.S. (2005) Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen.  Mol. Cell, 19, 741-751.
Kim, W., Spear, E.D., Ng, D.T.W. (2001) Yos9p detects and targets misfolded glycoproteins for ER-associated degradation. Mol. Cell, 19, 753-764.
Szathmary, R., Bielmann, R., Nita-Lazar, M., Burda, P., Jakob, C.A. (2005) Yos9 protein is essential for degradation of misfolded glycoproteins and may function as a lectin in ERAD.  Mol. Cell, 19, 765-775.
Cruciat, C-M., Hassler, C., Niehrs, C. (2006) The MRH protein erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.  J. Biol. Chem., 281, 12986-12993.
Barondes, S.H., Cooper, D.N.W., Gitt, M.A. and Leffler, H. (1994) Galectins structure and function of a large family of animal lectins. J. Biol. Chem., 269, 20807-20810.
Cooper, D.N.W. and Barondes, S.H. (1999) God must love galectins; He made so many of them. Glycobiology, 9, 979-984.
Leonidas, D.D., Vatzaki, E.H., Vorum, H., Celis, J.E., Madsen, P. and Acharya, K.R. (1998) Structural basis for the recognition of carbohydrates by human galectin-7. Biochemistry, 37, 13930-13940.
Liao, D.-I., Kapadia, G., Ahmed, H., Vasta, G.R. and Herzberg, O. (1994) Structure of S-lectin, a developmentally regulated vertebrate a-galactoside-binding protein. Proc. Natl. Acad. Sci. U.S.A., 91, 1428-1432.
Lobsanov, Y.D., Gitt, M.A., Leffler, H., Barondes, S.H. and Rini, J.M. (1993) X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9- resolution. J. Biol. Chem., 268, 27034-27038.
Swaminathan, G.J., Leonidas, D.D., Savage, M.P., Ackerman, S.J. and Acharya, K.R. (1999) Selective recognition of mannose by the human eosinophil Charcot-Leydon crystal protein (Galectin 10): a crystallographic study at 1.8 resolution. Biochemistry, 38, 13837-13843.
I-type lectins
Crocker, P., Clark, E.A., Filbin, M., Gordon, S., Jones, Y., Kehrl, J.H., Kelm, S., Le Douarin, N., Powell, L., Roder, J., Schnaar, R.L., Sgroi, D.C., Stamenkovic, K., Schauer, R., Schachner, M., van den Berg, T.K., van der Merwe, P.A., Watt, S.M. and Varki, A. (1998) Siglecs: a family of sialic-acid binding lectins. Glycobiology, 8, v.
Crocker, P.R. and Varki, A. (2001) Siglecs in the immune system.  Immunology, 103, 137-145.
Crocker, P.R. and Varki, A. (2001) Siglecs, sialic acid and innate immunity.  Trends in Immunology, 22, 337-342.
Nitchke, L. (2005) The role of CD22 and other inhibitory co-receptors in B-cell activation.  Curr. Opin. Immunol., 17, 290-297.
R-type lectins
Clausen, H. and Bennett, E.P. (1996) A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin type O-linked glycosylation. Glycobiology, 6, 635-646.
Fiete, D.J., Beranek, M.C. and Baenziger, J.U. (1998) A cysteine-rich domain of the "mannose" receptor mediates GalNAc-4-SO4 binding. Proc. Natl. Acad. Sci. U.S.A., 95, 2089-2093.
Fujimoto, Z., Kuno, A., Kaneko, S., Yoshida, S., Kobayashi, H., Kusakabe, I. and Mizuno, H. (2000) Crystal structure of Streptomyces olivaceoviridis E-86 b-xylanase containing xylan-binding domain. J. Mol. Biol., 300, 575-585.
Liu, Y., Chirino, A.J., Misulovin, Z., Leteux, C., Feizi, T., Nussenzweig, M.C. and Bjorkman, P.J. (2000) Crystal structure of the cysteine-rich domain of mannose receptor complexed with a sulfated carbohydrate ligand. J. Exptl. Med., 191, 1105-1115.
Hassan, H., Reis, C.A., Bennett, E.P., Mirgorodskaya, E., Roepstorff, P., Hollingsworth, M.A., Burchell, J., Taylor-Papadimitiou, J. and Clausen, H. (2000) The lectin domain of UDP-N-acetyl-D-galactosmine:polypeptide N-acetylgalactosaminyltransferase-T4 direct its glycopeptide specificities. J. Biol. Chem., 275, 38197-38205.
Murzin, A.G., Lesk, A.M. and Chothia, C. (1992) Beta-trefoil fold patterns of structure and sequence in the Kunitz inhibitors, interleukins-1b and 1a and fibroblast growth factors. J. Mol. Biol., 223, 531-543.
Rutenber, E., Ready, M. and Robertus, J.D. (1987) Structure and evolution of ricin B chain. Nature, 326, 624-626.
Rutenber, E. and Robertus, J.D. (1991) Structure of ricin B-chain at 2.5 resolution. Proteins, 10, 260-269.
Taylor, M.E. (1997) Evolution of a family of receptors containing multiple motifs resembling carbohydrate-recognition domains. Glycobiology, 7, R5-R8.
F-box lectins
Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T., Tanaka, K. (2004)  Structural basis of sugar-recognizing ubiquitin ligase.  Nat. Struct. Mol. Biol., 11, 365-370.
Yoshida, Y., Tokunaga, F., Chiba, T., Iwai, K., Tanaka, K., Tai, T. (2003) Fbs2 a new member of the E3 ubiquitin ligase family that recognizes sugar chains.  J. Biol. Chem., 278, 43877-43884.
Yoshida, Y., Adachi, E., Fukiya, K., Iwai, K., Tanaka, K. (2005)  Glycoprotein-specific ubiquitin ligases recognize N-glycans in unfolded substrates.  EMBO Rep, 6, 239-244.
Ohashi, T., Erickson, H.P. (1997) Two oligomeric forms of plasma ficolin have differential lectin activity.  J. Biol. Chem., 272, 14220-14226.
Matsushita, M., Fujita, T. (2001) Ficolins and the lectin complement pathway.  Immunological Reviews, 180, 78-85.
Ohashi, T., Erickson, H.P. (2004) The disulfide bonding pattern in ficolin mutlimers.  J. Biol. Chem., 279, 6534-6539.
Ma, Y.G., Cho, M.Y, Zhao, M., Park, J.W., Matsushita, M., Fujita, T., Lee, B.L. (2004)  Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement.  J. Biol. Chem., 279, 25307-25312.
Krarup, A., Thiel, S., Hansen, A., Fujita, T., Jensenius, J.C. (2004)  L-ficolin is a pattern recognition molecule specific for acetyl groups.  J. Biol. Chem., 279, 47513-47519.
Gokudan, S., Muta, T., Tsuda, R., Koori, K., Kawahara, T., Seki, N., Mizunoe, Y., Wai, S.W., Iwanaga, S., Kawabata, S-I. (1999)  Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen.  Proc. Natl. Acad. Sci. USA, 96, 10086-10091.
Chitinase-like lectins
Chang, N-C.A., Hung, S-I., Hwa, K-Y., Kato, I., Chen, J-E., Liu, C-H., Chang, A.C. (2001) A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin.  J. Biol. Chem., 276, 17497-17506.
Sun, Y-J., Chang, N-C.A., Hung, S-I., Chang, A.C., Chou, C-C., Hsiao, C-D. (2001) The crystal structure of a novel mammalian lectin, Ym1, suggests a saccharide binding site.  J. Biol. Chem., 276, 17507-17514.
Tsai, M.L., Liaw, S.H., Chang, N.C. (2004) The crystal structure of Ym1 at 1.31 A resolution.  J. Struct. Biol., 148, 290-296.
Fusetti, F., von Moeller, H., Houston, D., Rozeboom, H.J., Dijkstra, B.W., Boot, R.G., Aerts, J.M.F.G, van Aalten, D.M.F. (2002) Structure of human chitotriosidase.  J. Biol. Chem., 277, 25537-25544.
Fusetti, F., Pijning, T., Kalk, K.H., Bos, E., Dijkstra, B.W. (2003) Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39.  J. Biol. Chem., 278, 37753-37760.
Bigg, H.F., Wait, R., Rowan, A.D., Cawston, T.E. (2006) The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation.  J. Biol. Chem., 281, 21083-21095.
F-type lectins (fucolectins)
Saito, T., Hatada, M., Iwanaga, S., Kawabata, S. (1997)  A newly identified horseshoe crab lectin with binding specificity to O-antigen of bacterial lipopolysaccharides.  J. Biol. Chem., 272, 30703-30708.
Honda, S., Kashiwagi, M., Miyamoto, K., Takei, Y., Hirose, S. (2000) Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins.  J. Biol. Chem., 275, 33151-33157.
Bianchet, M.A., Odom, E.W., Vasta, G.R., Amzel, L.M. (2002)  A novel fucose recognition fold involved in innate immunity.  Nature. Struct. Biol., 9, 628-634.
Vasta, G.R., Ahmed, H., Odom, E.W. (2004)  Structural and functional diversity of lectin repertoires in invertebrates, protochordates and ectothermic vertebrates.  Curr. Op. Struct. Biol., 14, 617-630.
Vasta, G.R., Odom, E.W. (2006) Characterization of a binary tandem domain F-type lectin from striped bass (Morone saxatilis).  J. Biol. Chem., 281, 1698-1713.
Boraston, A.B., Wang, D., Burke, R.D. (2006)  Blood group antigen recognition by a Streptococcus pneumoniae virulence factor.  J. Biol. Chem., in press.
Nagata, S., Nakanishi, M., Nanba, R., Fujita, N. (2003)  Developmental expression of XEEL, a novel molecule of the Xenopus oocyte cortical granule lectin family.  Dev. Genes Evol., 213, 368-370.
Chang, B.Y., Peavy, T.R., Wardrip, N.J., Hedrick, J.L. (2004)  The Xenopus laevis cortical granule lectin: cDNA cloning, developmental expression, and identification of the eglectin family of lectins.  Comp. Biochem. Physiol. A. Mol. Integr. Physiol., 137, 115-129.
Abe, Y., Tokuda, M., Ishimoto, R., Azumi, K., Yokosawa, H. (1999)  A unique primary structure, cDNA cloning and function of a galactose-specific lectin from ascidian plasma.  Eur. J. Biochem., 261, 33-39.
Komiya, T., Tanigawa, Y., Hirohashi, S. (1998) Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice.  Biochem. Biophys. Res. Commun., 251, 759-762.
Pemberton, A.D., Knight, P.A., Gamble, J., Colledge, W.H., Lee, J.K., Pierce, M., Miller, H.R. (2004)  Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice.  J. Immunol., 173, 1894-1901.
Tsuji, S., Uehori, J., Matsumoto, M., Suzuki, Y., Matsuhisa, A., Toyoshima, K., Seya, T. (2001)  Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall.  J. Biol. Chem., 276, 23456-23463.
Suzuki, Y.A., Shin, K., Lonnerdal, B. (2001)  Molecular cloning and functional expression of a human intestinal lactoferrin receptor.  Biochemistry, 40, 15771-15779.
Lee, J.K, Schnee, J., Pang, M., Wolfert, M., Baum, L.G., Moremen, K.W., Pierce, M. (2001) Human homologs of the Xenopus oocyte cortical granule lectin XL35.  Glycobiology, 11, 65-73.
Schaffler, A., Neumeier, M., Herfarth, H., Furst, A., Scholmerich, J., Buchler, C. (2005)  Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.  Biochim. Biophys. Acta., 1723, 96-102.
Wrackmeyer, U., Hansen, G.H., Seya, T., Danielsen, E.M. (2006)  Intelectin: a novel lipid raft-associated protein in the enterocyte brush border.  Biochemistry, 45, 9188-9197.
Lee, J.K., Baum, L.G., Moremen, K., Pierce, M. (2004)  The X-lectins: a new family with homology to the Xenopus laevis oocyte lectin XL-35.  Glycoconj. J., 21, 443-450.
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This page last updated:
Wednesday, 01 January 2014
Animal lectins home
Contact information: This site is supported by:
Kurt Drickamer
Division of Molecular Biosciences
Faculty of Natural Sciences
Imperial College London