TY - JOUR AB - <jats:title>Abstract</jats:title><jats:p>There has been increasing interest in the development of small molecules that can selectively bind to Gquadruplex DNA structures. The latter have been associated with a number of key biological processes and therefore are proposed to be potential targets for drug development. Herein, we report the first example of a reductionactivated Gquadruplex DNA binder. We show that a new octahedral platinum(IV)–salphen complex does not interact with DNA in aqueous media at pH7.4; however, upon addition of bioreductants such as ascorbic acid or glutathione, the compound is readily reduced to the corresponding square planar platinum(II) complex. In contrast to the parent platinum(IV) complex, the insitu generated platinum(II) complex has good affinity for Gquadruplex DNA.</jats:p> AU - Bandeira,S AU - GonzalezGarcia,J AU - Pensa,E AU - Albrecht,T AU - Vilar,R DO - 10.1002/ange.201709968 EP - 319 PY - 2018/// SN - 0044-8249 SP - 316 TI - A RedoxActivated GQuadruplex DNA Binder Based on a Platinum(IV)–Salphen Complex T2 - Angewandte Chemie UR - http://dx.doi.org/10.1002/ange.201709968 VL - 130 ER -