TY - JOUR AB - Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3ß as a important modulator of miR biogenesis at Microprocessor level. Repression of GSK3ß activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of mature pri-miRs without altering levels or cellular locations of miR biogenesis proteins... AU - Fletcher,CE AU - Godfrey,JD AU - Shibakawa,A AU - Bushell,M AU - Bevan,CL DO - nar/gkw938 EP - 2828 PY - 2017/// SN - 2159-3345 SP - 2809 TI - A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis T2 - Nucleic Acid Research UR - http://dx.doi.org/10.1093/nar/gkw938 UR - http://hdl.handle.net/10044/1/41279 VL - 45 ER -