TY - JOUR AB - Interferon regulatory factor 5 (IRF5) is a key transcription factor involved in the control of theexpression of pro-inflammatory cytokine and responses to infection, however its role in regulatingpulmonary immune responses to allergen is unknown. We used genetic ablation, adenoviralvector-driven overexpression and adoptive transfer approaches to interrogate the role of IRF5 inpulmonary immunity and during challenge with the aero-allergen, house dust mite. Global IRF5deficiency resulted in impaired lung function and extracellular matrix (ECM) deposition. IRF5was also essential for effective responses to inhaled allergen, controlling airway hyper-responsiveness, mucus secretion and eosinophilic inflammation. Adoptive transfer of IRF5-deficient alveolar macrophages into the WT pulmonary milieu was sufficient to drive airwayhyper-reactivity, at baseline or following antigen challenge. These data identify IRF5-expressingmacrophages as a key component of the immune defence of the airways. Manipulation of IRF5activity in the lung could therefore be a viable strategy for the redirection of pulmonary immuneresponses and thus, the treatment of lung disorders. AU - Byrne,AJ AU - Weiss,M AU - Mathie,SA AU - Walker,S AU - Eames,HL AU - Saliba,D AU - Udalova,IA AU - Lloyd,CM DO - 10.1038/mi.2016.92 EP - 726 PY - 2016/// SN - 1935-3456 SP - 716 TI - A critical role for IRF5 in regulating allergic airway inflammation T2 - Mucosal Immunology UR - http://dx.doi.org/10.1038/mi.2016.92 UR - http://hdl.handle.net/10044/1/41192 VL - 10 ER -