TY - JOUR AB - A robust dithiocarbamate tether allows novel gadolinium units based on DOTAGA (q = 1) to be attached to the surface of gold nanoparticles (2.6 4.1 nm diameter) along with functional units offering biocompatibility, targeting and photodynamic therapy. A dramatic increase in relaxivity (r1) per Gd unit from 5.01 mM−1 s−1 in unbound form to 31.68 mM−1 s−1 (10 MHz, 37 °C) is observed when immobilised on the surface due to restricted rotation and enhanced rigidity of the Gd complex on the nanoparticle surface. The singlestep synthetic route provides a straightforward and versatile way of preparing multifunctional gold nanoparticles, including examples with conjugated zinctetraphenylporphyrin photosensitizers. The lack of toxicity of these materials (MTT assays) is transformed on irradiation of HeLa cells for 30 minutes (PDT), leading to 75% cell death. In addition to passive targeting, the inclusion of units capable of actively targeting overexpressed folate receptors illustrates the potential of these assemblies as targeted theranostic agents. AU - Chabloz,N AU - Perry,H AU - Yoon,I-C AU - Coulson,A AU - White,A AU - Stasiuk,G AU - Botnar,R AU - Wilton-Ely,J DO - 10.1002/chem.201904757 EP - 4566 PY - 2020/// SN - 0947-6539 SP - 4552 TI - Combined magnetic resonance imaging and photodynamic therapy using polyfunctionalised nanoparticles bearing robust gadolinium surface units T2 - Chemistry – A European Journal UR - http://dx.doi.org/10.1002/chem.201904757 UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201904757 UR - http://hdl.handle.net/10044/1/76438 VL - 26 ER -