TY - JOUR AB - Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes. AU - Edwards,MR AU - Saglani,S AU - Schwarze,J AU - Skevaki,C AU - Smith,JA AU - Ainsworth,B AU - Almond,M AU - Andreakos,E AU - Belvisi,MG AU - Chung,KF AU - Cookson,W AU - Cullinan,P AU - Hawrylowicz,C AU - Lommatzsch,M AU - Jackson,D AU - Lutter,R AU - Marsland,B AU - Moffatt,M AU - Thomas,M AU - Virchow,JC AU - Xanthou,G AU - Edwards,J AU - Walker,S AU - Johnston,SL AU - members,of the EARIP WP2 working group DO - 10.1183/13993003.02448-2016 PY - 2017/// SN - 1399-3003 TI - Addressing unmet needs in understanding asthma mechanisms: From the European Asthma Research and Innovation Partnership (EARIP) Work Package (WP)2 collaborators T2 - European Respiratory Journal UR - http://dx.doi.org/10.1183/13993003.02448-2016 UR - http://www.ncbi.nlm.nih.gov/pubmed/28461300 UR - http://hdl.handle.net/10044/1/45616 VL - 49 ER -