TY - JOUR AB - Background: Fermentable carbohydrates (FCHO) have beenshown to improve insulin sensitivity in normoglycaemic andinsulin-resistant subjects. However, there are no data onsubjects with prediabetes. We aimed to investigate the effectof the FCHO inulin, on glucose homeostasis in subjectswith prediabetes. Methods: In a double-blind and placebocontrolledcrossover study, 40 volunteers with prediabeteswere randomly allocated to take 30 g/day of inulin or cellulosefor 2 weeks in a crossover trial, following a 4-week doseescalationrun-in. Fasting insulin and glucose were measuredfor all subjects. Fifteen of the 40 subjects also underwenta meal tolerance test to assess insulin sensitivity, freefatty acids and glucagon-like peptide-1 concentrations. Asubanalysis was carried out to examine any differences betweenthe prediabetes subtypes. Results: Inulin was associatedwith a significant increase in (0–30 min) incremental AUC(iAUC) for insulin (treatment: p < 0.04) and (0–60 min) iAUC forinsulin (treatment: p < 0.04) compared to control. There wasa significant reduction in insulin resistance measured by thehomeostatic model assessment in the isolated-impairedfasting glucose (p < 0.05) but not in the isolated-impaired glucose tolerance groups (p = 0.59). Conclusion: The FCHO,inulin, may have unique metabolic effects that are of particularbenefit to people at risk of diabetes, which warrantfurther investigation. AU - Guess,ND AU - Dornhorst,A AU - Oliver,N AU - Frost,GS DO - 10.1159/000441626 EP - 34 PY - 2015/// SN - 1421-9697 SP - 26 TI - A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes T2 - Annals of Nutrition and Metabolism UR - http://dx.doi.org/10.1159/000441626 VL - 68 ER -