TY - JOUR AB - IEEE Objective: Inappropriate dosing of patients with antibiotics is a driver of antimicrobial resistance, toxicity, and poor outcomes of therapy. In this paper, we investigate, in silico, the hypothesis that the use of a closed-loop control system could improve the attainment of pharmacokinetic-pharmacodynamic targets for antimicrobial therapy, where wide variations in target attainment have been reported. This includes patients in critical care, patients with renal disease and patients with obesity. AU - Herrero,P AU - Rawson,TM AU - Philip,A AU - Moore,LSP AU - Holmes,AH AU - Georgiou,P DO - 10.1109/TBME.2017.2787423 EP - 2236 PY - 2018/// SN - 0018-9294 SP - 2231 TI - Closed-loop control for precision antimicrobial delivery: an In silico proof-of-concept T2 - IEEE Transactions on Biomedical Engineering UR - http://dx.doi.org/10.1109/TBME.2017.2787423 UR - http://hdl.handle.net/10044/1/56020 VL - 65 ER -