TY - JOUR AB - Imaging the heart is central to cardiac phenotyping but in clinical practice this has been restricted to macroscopic interrogation. Diffusion tensor cardiovascular magnetic resonance (DT-CMR) is a novel, non-invasive technique which is beginning to unlock details of this microstructure in humans in-vivo. DT-CMR demonstrates the helical cardiomyocyte arrangement that drives rotation and torsion. Sheetlets (functional units of cardiomyocytes, separated by shear layers) have been shown to reorientate between diastole and systole, revealing how microstructural function facilitates cardiac thickening. Measures of tissue diffusion can also be made; fractional anisotropy (a measure of myocyte organisation) and mean diffusivity (a measure of myocyte packing). Abnormal myocyte orientation and sheetlet function has been demonstrated in congenital heart disease, cardiomyopathy and after myocardial infarction. It is too early to predict the clinical importance of DT-CMR, but such unique in-vivo information will likely prove valuable in early diagnosis and risk prediction of cardiac dysfunction and arrhythmias. AU - Khalique,Z AU - Ferreira,P AU - Scott,A AU - Nielles-Vallespin,S AU - Firmin,D AU - Pennell,D DO - 10.1016/j.jcmg.2019.07.016 EP - 1255 PY - 2020/// SN - 1936-878X SP - 1235 TI - Diffusion tensor cardiovascular magnetic resonance: a clinical perspective T2 - JACC: Cardiovascular Imaging UR - http://dx.doi.org/10.1016/j.jcmg.2019.07.016 UR - https://www.sciencedirect.com/science/article/pii/S1936878X19307259?via%3Dihub UR - http://hdl.handle.net/10044/1/72598 VL - 13 ER -