TY - JOUR AB - Using a combination of high pressure wide angle X-ray scattering exper-iments and molecular dynamics simulations, we probe the e ect of thearchetypal general anaesthetic halothane on the lipid hydrocarbon chainpacking and ordering in model bilayers and the variation in these parame-ters with pressure. Incorporation of halothane into the membrane causes anexpansion of the lipid hydrocarbon chain packing at all pressures but thee ect of halothane incorporation on the hydrocarbon chain order parameteris signi cantly reduced at elevated pressure. AU - McCarthy,NL AU - Brooks,NJ AU - Tyler,AII AU - ElGamacy,M AU - Welche,P AU - Payne,MC AU - Chau,PL DO - 10.1016/j.cplett.2016.12.041 EP - 27 PY - 2017/// SN - 0009-2614 SP - 21 TI - A combined X-ray scattering and simulation study of halothane in membranes at raised pressures T2 - Chemical Physics Letters UR - http://dx.doi.org/10.1016/j.cplett.2016.12.041 UR - http://www.sciencedirect.com/science/article/pii/S000926141630999X UR - http://hdl.handle.net/10044/1/43270 VL - 671 ER -