Computational models show that functional remodeling, not anatomy, reshapes physiological determinants of cardiac performance in hypertrophic cardiomyopathy. - Rodero, C; Curran, L; Lanyon, CW; Inglese, P; Qayyum, A; Barrows, RK; Solis-Lemus, JA; Rahmani, S; Strocchi, M; Lee, AWC; Baptiste, TMG; Cicci, L; et al. (J Mol Cell Cardiol, 2026)