Testing a participant of a dementia study at Imperial College London's School of Public Health

What type of studies are being conducted?

Studies may vary from simple questionnaires to clinical trials investigating new preventative treatments. Those on the register will be given full details of each study and will have time to consider whether they would like to get involved. You are under no obligation to take part in any study just because you have agreed to be on the register.

Current Studies

The CHARIOT: PRO Substudy 2

Participants that were excluded from the CHARIOT: PRO Substudy in a randomised process are being invited to attend a one-off visit at the Research Hub at Charing Cross Hospital. They will complete further testing and samples.

This study is no longer seeking new volunteers

Generation Programme

Generation 1 and 2

The Generation study was sponsored by Novartis and Amgen as part of the Alzheimer’s prevention initiative. An anti-amyloid drug was being assessed for safety and efficacy in the prevention or delay of the onset of Alzheimer's in people at risk for developing symptoms based on their age and genetic status. This study was discontinued across all sites worldwide on 11th July due to safety concerns. The AGE Research Unit screened many volunteers for inclusion in the trial; however, only a small number were actually started on treatment. Thus, we are pleased that not many of our participants were exposed to potential risks to their safety. People who were on treatment are being followed up for 6 months to provide information on their health and cognitive status.

Press Release

 

The CHARIOT: PRO Substudy

An observational study examining changes in cognition over time, and how we can best identify these at an early stage. Involves a medical health check, physical and neurological examinations and cognitive assessments.

Previous research studies

CHARIOT: PRO Main Study

An observational study examining changes in cognition over time, and how we can best identify these at an early stage. Involves medical health check, physical and neurological examinations and cognitive assessments.

MULTIMODE Study

A pilot study to gather feedback on using a mobile phone app to receive a dementia risk score and guidance on how to lower this risk score.

 

Previous Studies

Neurovision

This study involves research into changes in the eye that might accompany the early development of Alzheimer’s Disease. We use an experimental imaging technique to highlight plaques in the back of the eye.  

The UK Prescreening Study

A study to assess memory function in individuals who feel they have noticed recent changes in their memory and to identify people interested in being involved in preventative trials.

Previous Studies

TOMMORROW

An international clinical trial to determine whether a genetic biomarker can predict an individual’s risk of developing memory problems and determine whether a specific treatment would help delay the onset of memory problems in people who are at high risk.

Volunteers who have consented to join the CHARIOT register are invited to participate in our research studies.

Please visit our Get involved page to find out more.