Key information

Dates:
31 August - 11 September, 2020

Virtual online course

Fees:
Imperial College London staff and students: £100
EIT-Health EpidemPrev PhD students: No fee
Other applicants: £500

Course organisers:
Dr Sara Ahmadi-Abhari
Professor Lefkos Middleton
Dr Geraint Price

How to apply:
Send a CV and a short statement (max 300 words) explaining reasons for attending the course via our registration page.

Register

Course overview

The aim of the advanced course on dementia prevention is to provide training on the methods and recent advances in population based epidemiological research on dementia. With ageing of the populations and increasing numbers of people living with dementia worldwide, there is growing interest in the academic and pharmaceutical industry sectors, as well as governmental and non-governmental organizations, in dementia research and prevention. The skills acquired by this course are highly relevant to employment in any such organizations where there is interest in research, consultancy, or policy setting related to ageing and dementia.

During the course an introduction to dementia pathophysiology and advances in diagnosis and management of the condition will be provided followed by extensive discussions on the research methods and up to date findings on the epidemiology, and lifestyle, biological, genomic and metabolomic risk factors for Alzheimer’s disease and dementia. Discussions will follow on recent advances in research on pharmaceutical and non-pharmaceutical interventions to prevent and treat dementia. The two weeks course includes two days of training in basic epidemiological concepts and biostatistics for attendees who do not have prior formal training in epidemiology/biostatistics.

Each day of the course is typically comprised of 3 to 4 lectures of 45 minutes to 1-hour duration by renowned experts in the field and at least one 2-hour interactive/practical training session. Students will be provided with reading material in advance through the Imperial College online secure platform (Blackboard) to prepare for the interactive/practical sessions. The interactive/practical sessions are designed to consolidate acquired knowledge, provide a forum to practice taught material, develop practical skills in applying the taught elements, to monitor student progress, provide and receive feedback on learning, course content and implementation.

Upon completion of the two week course you will be expected to gain a broad understanding of the biology and pathophysiology of dementia, to understand research methods applied to population based dementia research and critically appraise epidemiological research papers on the topic, gain an understanding of advances and challenges in epidemiological dementia research, to be able to identify gaps in dementia research and design a population based epidemiological or intervention study to answer a research question on the topic of dementia prevention and interpret the findings. A minimum of 80% attendance is required to receive certificate of attendance in the course.

Timetable

This is a two-weeks course running from 9:00am – 5:00pm each day. Students are expected to do an additional estimated 20 hours of independent study to prepare for the interactive practical sessions and do further reading for the topic covered in the course.

Tentative timetable

Week 1 Monday 31 August Introduction
Understanding Epidemiology (study design)
Understanding Epidemiology (measures of association and disease burden)
Understanding Epidemiology (confounding)
Interactive/Practical session
  Tuesday 1 September  Understanding Epidemiology (bias)
Understanding biostatistics (descriptive and analytic statistics)
Understanding biostatistics (P-value and confidence interval)
Understanding biostatistics (Multivariable regression analysis)
Interactive/Practical session
  Wednesday 2 September Nosology of Late Onset Dementia
Diagnosis of Alzheimer's disease (staging/biomarkers/imaging)
Pathophysiology of dementia and dementia types from a clinical perspective
Fluid biomarkers and dementia
  Thursday 3 September  Amyloid cascade in the pathophysiology of dementia
Neuroinflammation and dementia
Assessment of cognitive function
Interactive/Practical session
  Friday 4 September Modifiable and non-modifiable risk factors for dementia
Risk prediction models
Week 2 Monday 7 September Interactive/pracitcal session
Global burden of dementia
Multimorbidities in ageing
  Tuesday 8 September Oxidative stress, mitochondrial process and dementia
TBC
Cognitive reserve
Interactive/practical session
  Wednesday 9 September Metabolomics and dementia
Proteomics and dementia
Genomics and dementia
Interactive/practical session
  Thursday 10 September Socioeconomic inequalities in development of dementia
Prevention and treatment of dementia and related challenges
Non-pharmacological interventions
Data sources for population based dementia research
  Friday 11 September Pharmacological interventions
Drug Repurposing for treatment and prevention of dementia
Big data and machine learning approaches to dementia
* There may be changes to the timetable. Any changes will be communicated to all applicants
Summary of the table's contents

Confirmed speakers

Prof Lefkos Middleton (Imperial College London)
Prof. Miia Kivipelto (Imperial College London and Karolinska Institutet)
Prof. Elio Riboli (Imperial College London)
Prof. Henrik Zetterberg (UCL)
Prof. Stan Finkelstein (Harvard University and MIT)
Prof. Roy Welsch (MIT)
Prof. Mark Albers (Harvard University)
Prof. Joao Malva (University of Coimbra)
Prof. Lene Rasmussen (University of Copenhagen)
Prof. Mika Kivimaki (UCL)
Prof. Julian Griffin (Imperial College London)
Dr Paresh Malhotra (Imperial College London)
Dr Magdalena Sastre (Imperial College London)
Dr Alina Solomon (University of Eastern Finland and Karolinska Institutet)
Dr Shireen Sindi (Karolinska Instituten)
Dr Amanda Heslegrave (UCL)
Dr Rui Pinto (Imperial College London)
Dr Raha Pazoki (Brunel University and Imperial College London)
Dr Sumali Bajaj (Imperial College London)
Dr Chinedu Udeh-Momoh (Imperial College London)
Dr Celeste de Jager (Imperial College London)
Dr Geraint Price (Imperial College London)
Dr Sara Ahmadi-Abhari (Imperial College London)

How to apply

Send a CV and a short statement (max 300 words) explaining reasons for attending the course via our registration form.