Key information

Dates:
20 September – 1 October, 2021

Virtual online course

Fees:
Imperial College London staff and students: £150
EIT-Health EpidemPrev PhD students: No fee
Other applicants: £500

Course organisers:
Dr Sara Ahmadi-Abhari
Professor Lefkos Middleton

How to apply:
Send a CV and a short statement (max 300 words) explaining reasons for attending the course via our registration page.

Register your place

Course overview

The aim of the advanced course on dementia prevention is to provide training on the methods and recent advances in population based epidemiological research on dementia. With ageing of the populations and increasing numbers of people living with dementia worldwide, there is growing interest in the academic and pharmaceutical industry sectors, as well as governmental and non-governmental organizations, in dementia research and prevention. The skills acquired by this course are highly relevant to employment in any such organizations where there is interest in research, consultancy, or policy setting related to ageing and dementia.

During the course an introduction to dementia pathophysiology and advances in diagnosis and management of the condition will be provided followed by extensive discussions on the research methods and up to date findings on the epidemiology, and lifestyle, biological, genomic and metabolomic risk factors for Alzheimer’s disease and dementia. Discussions will follow on recent advances in research on pharmaceutical and non-pharmaceutical interventions to prevent and treat dementia. The two weeks course includes two days of training in basic epidemiological concepts and biostatistics for attendees who do not have prior formal training in epidemiology/biostatistics.

Each day of the course is typically comprised of 3 to 4 lectures of 45 minutes to 1-hour duration by renowned experts in the field and at least one 2-hour interactive/practical training session. Students will be provided with reading material in advance through the Imperial College online secure platform (Blackboard) to prepare for the interactive/practical sessions. The interactive/practical sessions are designed to consolidate acquired knowledge, provide a forum to practice taught material, develop practical skills in applying the taught elements, to monitor student progress, provide and receive feedback on learning, course content and implementation.

Upon completion of the two week course you will be expected to gain a broad understanding of the biology and pathophysiology of dementia, to understand research methods applied to population based dementia research and critically appraise epidemiological research papers on the topic, gain an understanding of advances and challenges in epidemiological dementia research, to be able to identify gaps in dementia research and design a population based epidemiological or intervention study to answer a research question on the topic of dementia prevention and interpret the findings. A minimum of 80% attendance is required to receive certificate of attendance in the course.

Timetable

 DateTimeTitleLeacturer
Precourse 20th September 10:00 - 10:30  Introduction Prof. Lefkos Middleton (Imperial College London)
    10:30 - 11:30 Understanding Epidemiology (study design) Dr. Sara Ahmadi (Imperial College London)
    12:00 - 13:00 Understanding Epidemiology (measures of association and disease burden)  
    14:00 - 15:00 Understanding Epidemiology (confounding)  
    15:30 - 17:00 Interactive/Practical session  
  21st September 10:00 - 11:00 Understanding Epidemiology (bias) Dr Sara Ahmadi (Imperial College London)
    11:30 - 12:30 Understanding biostatistics (descriptive and analytic statistics)  
    13:30 - 14:30 Understanding biostatistics (P-value and confidence interval) Dr Sumali Bajaj (University of Oxford)
    14:45 - 15:45 Understanding biostatistics (Multivariable regression analysis Dr Sara Ahmadi (Imperial College London)
    16:00 - 17:30 Interactive/Practical Session  
Summary of the table's contents
 DateTimeTitleLeacturer
Week One 22nd September 10:00 - 11:00  Pathophysiology of dementia and dementia types from a clinical perspective Dr. Paresh Malhotra (Imperial College London)
    11:15 - 13:00 Late Onset Dementias and Alzheimer’s disease: Nosology, Classification & Staging Prof. Lefkos Middleton (Imperial College London)
    14:00 - 15:00 Biological mechanisms implicated in the development of dementia Dr. Magdalena Sastre (Imperial College London)
    15:30 - 16:30 Neuroinflammation and dementia Prof. Joao Malva (University of Coimbra)
  23rd September 9:30 - 10:30 Oxidative stress, mitochondrial process and dementia Prof. Lene Rasmussen (University of Copenhagen)
    11:00 - 13:00 Cognitive assessment Dr. Geraint Price / Dr. Celeste de Jager (Imperial College London
    14:00 - 15:30 Neuroimaging: Introduction to structural, functional and molecular imaging in dementia research and clinical practice Dr. David Scott (Bioclinica, Oakland, USA)
    16:00 - 17:30 Neuroimaging: Disentangling the biology underlying Alzheimer's disease through novel PET methodologies Dr. Heather Wilson (University of Exeter)
  24th September 10:00 - 11:00 Socioeconomic inequalities in development of dementia Prof. Mika Kivimaki (University College London)
    11:30 - 12:30 Global burden of dementia Dr. Sara Ahmadi (Imperial College London)
    14:00 - 15:00 Neuroimaging: Clinical perspective on applications of neuroimaging in dementia Prof. Gil Rabinovivi (University California San Francisco (UCSF))
    15:15 - 16:15 Advanced neuroimaging analytic methods Dr. Duygu Tosun (UCSF)
    16:30 - 17:30 Integration of neuroimaging in multi-dimensional Machine Learning studies: the future Prof. Maxine Descoteaux (Imeka/ Sherbrook, Canada)
    17:30 - 18:00 Q&A and discussion  
* There may be slight changes to the timetable. Any changes will be communicated to all applicants.
Summary of the table's contents
 DateTimeTitleLeacturer
Week Two 27nd September 10:00 - 17:00 

Modifiable risk factors for development of dementia

Risk Prediction Models
Interactive/Practical session

Prof. Alina Solomon (Karolinska Institute, University of Eastern Finland)

Dr. Shireen Sindi (Karolinska Institute)

  28th September 9:30 - 10:45 Genomics, Epigenomics and dementia Dr. Sarah Marzi (UK Dementia Research Institute at Imperial College London)
    11:00 - 12:00 Proteomics and dementia Dr. Anna Matton (Karolinska Institute)
    12:15 - 13:15 Metabolomics and dementia Dr. Oliver Robinson (Imperial College London)
    14:00 - 16:00 Fluid biomarkers and dementia Prof. Henrik Zetterberg (University of Gothenburg, University College London)
    17:00 - 18:00 nteractive/practical session  
  29th September 10:00 - 13:00 Cognitive reserve and resilience Dr. Chi Udeh-Momoh (Imperial College London)
    14:00 - 18:00 Interactive/practical session - designing a research study  
  30th September 9:30 - 11:00 Multimorbidity in Ageing Prof. Elio Riboli (Imperial College London)
    11:15 - 13:00

Pharmacological interventions

Non-pharmacological interventions in prevention and treatment of dementia

Prof. Miia Kivipelto (Karolinska Institute, Imperial College London)

Dr. Francesca Mangialasche (Karolinska Institute)

    14:30 - 16:00 Neuromodulation Dr. Nir Grossman (UK Dementia Research Institute at Imperial College London)
  1st October 10:00 - 11:00 Drug repurposing for prevention and treatment of dementia Prof. Mark Albers (Harvard University)
    11:30 - 12:30 Drug repurposing for prevention and treatment of dementia - Diabetes as an example Prof. Stan Finkelstein (Harvard University, MIT)
Dr. Bang Zheng (Imperial College London)
    13:30 - 16:00 Machine learning approaches for research in ageing and dementia Prof. Roy Welsch (MIT)
* There may be slight changes to the timetable. Any changes will be communicated to all applicants.
Summary of the table's contents

How to apply

Send a CV and a short statement (max 300 words) explaining reasons for attending the course via our registration form.