Key information

Dates:
9 September - 20 September, 2019

Fees:
Full course (main course + pre-course): £1500
Main course only: £1300
Imperial College students and members reduced fee: £250

Course organisers:
Dr Sara Ahmadi-Abhari
Professor Lefkos Middleton
Dr Geraint Price

How to apply:
Send a CV and a short statement (max 300 words) explaining reasons for attending the course via our registration page.

Register

Course overview

The aim of the advanced course on dementia prevention is to provide training on the methods and recent advances in population based epidemiological research on dementia. With ageing of the populations and increasing numbers of people living with dementia worldwide, there is growing interest in the academic and pharmaceutical industry sectors, as well as governmental and non-governmental organizations, in dementia research and prevention. The skills acquired by this course are highly relevant to employment in any such organizations where there is interest in research, consultancy, or policy setting related to ageing and dementia.

During the course an introduction to dementia pathophysiology and advances in diagnosis and management of the condition will be provided followed by extensive discussions on the research methods and up to date findings on the epidemiology, and lifestyle, biological, genomic and metabolomic risk factors for Alzheimer’s disease and dementia. Discussions will follow on recent advances in research on pharmaceutical and non-pharmaceutical interventions to prevent and treat dementia. The two weeks course includes two days of training in basic epidemiological concepts and biostatistics for attendees who do not have prior formal training in epidemiology/biostatistics.

Each day of the course is typically comprised of 3 to 4 lectures of 45 minutes to 1-hour duration by renowned experts in the field and at least one 2-hour interactive/practical training session. Students will be provided with reading material in advance through the Imperial College online secure platform (Blackboard) to prepare for the interactive/practical sessions. The interactive/practical sessions are designed to consolidate acquired knowledge, provide a forum to practice taught material, develop practical skills in applying the taught elements, to monitor student progress, provide and receive feedback on learning, course content and implementation.

Upon completion of the two week course you will be expected to gain a broad understanding of the biology and pathophysiology of dementia, to understand research methods applied to population based dementia research and critically appraise epidemiological research papers on the topic, gain an understanding of advances and challenges in epidemiological dementia research, to be able to identify gaps in dementia research and design a population based epidemiological or intervention study to answer a research question on the topic of dementia prevention and interpret the findings. A minimum of 80% attendance is required to receive certificate of attendance in the course.

Timetable

This is a two-weeks course running from 9:00am – 5:00pm each day. Students are expected to do an additional estimated 20 hours of independent study to prepare for the interactive practical sessions and do further reading for the topic covered in the course.

Tentative timetable

Pre-Course Day 1
9/9 
AM 9:00-10:00 Introduction
10:15-11.15 Understanding Epidemiology (study design)
11:45-12:45 Understanding Epidemiology (measures of association and disease burden)
    PM 13:30-14:30 Understanding Epidemiology (confounding)
15:00-17:00 Interactive/Parctical session
  Day 2
10/9
AM 9:00-10:00 Understanding Epidemiology (bias)
10:15-11:15 Understanding biostatistics (descriptive and analytic statistics)
11:45-12:45 Understanding biostatistics (P-value and confidence interval)
    PM 13:30-14:30 Understanding biostatistics (Multivariable regression analysis)
15:00-17:00 Interactive/Practical session
Week 1 Day 3
11/9
AM 9:00-10:00 Pathophysiology of dementia and dementia types from a clinical perspective
10:15-11:15 Dementia nosology: deciphering complexity and heterogeneity
11:45-12:45 Diagnosis of dementia and evolving concepts 1 (assessment of cognitive function)
    PM 13:30-14:30 Diagnosis of dementia and evolving concepts  2 (staging/biomarkers/imaging)
15:00-17:00 Interactive/Practical session
  Day 4
12/9
AM 9:00-10:00 Inflammation and dementia
10:15-11:15 Amyloid Cascade, inflammation and dementia
11:45-12:45 Oxidative stress, mitochondrial process and dementia
    PM 13:30-14:30 Socioeconomic inequalities in dementia
15:00-17:00 Interactive/Practical session
  Day 5
13/9
AM 9:00-10:00 Multimorbidity in old age
10:15-11:15 Global burden of dementia
11:45-12:45 Fluid biomarkers and dementia
    PM 13:30-14:30 Cognitive reserve
15:00-17:00 Interactive/Practical session
Week 2 Day 6
16/9
  9:00-17:00 Modifiable risk factors
Interactive/Practical session
  Day 7
17/9
AM 9:00-10:00 Genetic and non-modifiable risk factors
10:15-11:15 Risk Prediction Models
11:45-12:45 Interactive/Practical session
    PM 13:30-14:30 Immunotherapies in dementia
15:00-17:00 Interactive/Practical session
  Day 8
18/9
AM 9:00-10:00 Introduction to genomics
10:15-11:15 Introduction to metabolomics
11:45-12:45 genomics and metabolomic findings related to dementia
    PM 13:30-14:30 genomics and metabolomic findings related to dementia
15:00-17:00 Interactive/Practical session
  Day 9
19/9
  9:00-17:00 Prevention and treatment of dementia and related challenges
Chariot Register
  Day 10
20/9
AM 9:00-12:00 Big data and machine learning approaches to dementia
    PM 13:00-17:00 Design of an epidemiological or intervention study practical group session
* There may be changes to the timetable. Any changes will be communicated to all applicants
Summary of the table's contents

Faculty

Prof Lefkos Middleton (Imperial College London)
Prof. Miia Kivipelto (Imperial College London and Karolinska Institute)
Prof Elio Riboli (Imperial College London)
Prof. Henrik Zetterberg (UCL)
Prof. Joao Malva (University of Coimbra)
Prof. Lene Rasmussen (University of Copenhagen)
Prof Stan Finkelstein (Harvard University and MIT)
Prof Roy Welsch (MIT)
Prof Mika Kivimaki (UCL)
Prof. Robert Perneczky (Ludwig Maximilian University of Munich)
Dr Abbas Dehghan (Imperial College London)
Dr Alina Solomon (University of Eastern Finland and Karolinska Institute)
Dr Magdalena Sastre (Imperial College London)
Dr Paresh Malhotra (Imperial College London)
Dr Rui Pinto (Imperial College London)
Dr Raha Pazoki (Imperial College London)
Dr Jian Huang (Imperial College London)
Dr Ibrahim Karaman (Imperial College London)
Dr Shireen Sindi (Karolinska Institute)
Dr Chinedu Udeh-Momoh (Imperial College London)
Dr Francesca Mangialasche (Karolinska Institute)
Dr Catherine Robb (Imperial College London)
Mrs Emily Pickering (Imperial College London)
Dr Julien Delireu (University of Toulouse)
Dr Celeste de Jager (Imperial College London)
Dr Geraint Price (Imperial College London)
Dr Sara Ahmadi-Abhari (Imperial College London).

* Some lecturers might change from year to year and might not be able to teach due to unforeseen circumstances. Please get in touch with course organizers if you would like to confirm if any particular lecturer will be teaching on the course. 

How to apply

Send a CV and a short statement (max 300 words) explaining reasons for attending the course via our registration form.