Citation

BibTex format

@article{Boddy:2019:10.1002/anie.201812925,
author = {Boddy, AJ and Affron, DP and Cordier, CJ and Rivers, EL and Spivey, AC and Bull, JA},
doi = {10.1002/anie.201812925},
journal = {Angew Chem Int Ed Engl},
pages = {1458--1462},
title = {Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle "Stitching" by N-H Insertion and Cyclization.},
url = {http://dx.doi.org/10.1002/anie.201812925},
volume = {58},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Methods that provide rapid access to new heterocyclic structures in biologically relevant chemical space provide important opportunities in drug discovery. Here, a strategy is described for the preparation of 2,2-disubstituted azetidines, pyrrolidines, piperidines, and azepanes bearing ester and diverse aryl substituents. A one-pot rhodium catalyzed N-H insertion and cyclization sequence uses diazo compounds to stitch together linear 1,m-haloamines (m=2-5) to rapidly assemble 4 -, 5 -, 6 -, and 7 -membered saturated nitrogen heterocycles in excellent yields. Over fifty examples are demonstrated, including examples with diazo compounds derived from biologically active compounds. The products can be functionalized to afford α,α-disubstituted amino acids and applied to fragment synthesis.
AU - Boddy,AJ
AU - Affron,DP
AU - Cordier,CJ
AU - Rivers,EL
AU - Spivey,AC
AU - Bull,JA
DO - 10.1002/anie.201812925
EP - 1462
PY - 2019///
SP - 1458
TI - Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle "Stitching" by N-H Insertion and Cyclization.
T2 - Angew Chem Int Ed Engl
UR - http://dx.doi.org/10.1002/anie.201812925
UR - https://www.ncbi.nlm.nih.gov/pubmed/30516342
UR - http://hdl.handle.net/10044/1/66668
VL - 58
ER -