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Synthetic Biology underpins advances in the bioeconomy
Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.
As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.
@article{Stopnitzky:2019:10.1103/PhysRevE.99.042115,
author = {Stopnitzky, E and Still, S and Ouldridge, TE and Altenberg, L},
doi = {10.1103/PhysRevE.99.042115},
journal = {Physical Review E},
title = {Physical limitations of work extraction from temporal correlations.},
url = {http://dx.doi.org/10.1103/PhysRevE.99.042115},
volume = {99},
year = {2019}
}
TY - JOUR
AB - Recently proposed information-exploiting systems extract work from a single heat bath by using temporal correlations on an input tape. We study how enforcing time-continuous dynamics, which is necessary to ensure that the device is physically realizable, constrains possible designs and drastically diminishes efficiency. We show that these problems can be circumvented by means of applying an external, time-varying protocol, which turns the device from a "passive," free-running machine into an "actively" driven one.
AU - Stopnitzky,E
AU - Still,S
AU - Ouldridge,TE
AU - Altenberg,L
DO - 10.1103/PhysRevE.99.042115
PY - 2019///
SN - 1539-3755
TI - Physical limitations of work extraction from temporal correlations.
T2 - Physical Review E
UR - http://dx.doi.org/10.1103/PhysRevE.99.042115
UR - https://www.ncbi.nlm.nih.gov/pubmed/31108699
UR - http://hdl.handle.net/10044/1/70526
VL - 99
ER -