The group is highly multidisciplinary, with researchers working on synthesis and structural biology, proteomics and cell biology, on in vitro and in vivo systems, often undertaking work in collaboration with labs at Imperial in Medicine, Engineering and Natural Sciences, and groups at institutes and companies across the UK and worldwide. Group membership is also highly diverse - more than 145 researchers have worked in our group over the years, encompassing 28 nationalities.

Staff

Dr Sebastian Andrei

Doctor Sebastian Andrei

Dr Sebastian Andrei
Marie Skłodowska-Curie research associate, structure & role of hedgehog acyltransferase (62)

Dr Edward Bartlett

Edward Bartlett

Dr Edward Bartlett
Research associate and lab manager (chemical biology)

Dr Fangyuan Cao

Fangyuan Cao

Dr Fangyuan Cao
Pfizer research associate in chemical proteomics

Dr Daniel Conole

Dr Daniel Conole

Dr Daniel Conole
Pfizer research associate in chemical proteomics

Dr Elena De Vita

Elena De Vita

Dr Elena De Vita
Marie Skłodowska-Curie research fellow in medicinal chemistry & covalent drug design (14, 54)

Dr Patrycja Michalska Dziama

Patrcyja Dziama

Dr Patrycja Michalska Dziama
Marie Curie Fellow in chemical biology and novel probe discovery technology

Dr Janine Gray

Dr Janine Gray

Dr Janine Gray
Research associate in antimicrobial resistance (68)

Dr Jack Houghton

Dr Jack Houghton

Dr Jack Houghton
Research associate in chemical proteomics

Dr Wouter Kallemeijn

Wouter

Dr Wouter Kallemeijn
EPSRC IAA fellow in chemical biology

Dr Daniel Lucy

Dr Daniel Lucy

Dr Daniel Lucy
WWCR research associate in chemical biology - unlocking the KLK activome

Dr Milon Mondal

Milon Mondal

Dr Milon Mondal
Marie Skłodowska-Curie fellow in chemical proteomics

Dr Tony Ocasio

Dr Tony Ocasio

Dr Tony Ocasio
Senior laboratory research scientist at The Francis Crick Institute

Dr Folake Orafidiya

Folake

Dr Folake Orafidiya
Myricx research scientist, cancer biology (60)

Dr Rita Petracca

Dr Rita Petracca

Dr Rita Petracca
Marie Skłodowska-Curie fellow in chemical biology

Dr Masha Shchepinova

Dr Masha Shchepinova

Dr Masha Shchepinova
BBSRC research associate in GPCR chemical biology (34-36)

Dr Ravi Singh

Doctor Ravi Singh

Dr Ravi Singh
Lab manager and research associate in medicinal chemistry (39, 62, 67-71)

Dr James Sipthorp

Dr James Sipthorp

Dr James Sipthorp
CRUK research associate in chemical biology, protein S-acylation

Dr Lior Soday

Dr Lior Soday

Dr Lior Soday
Research associate in chemical proteomics

Christelle Soudy

Christelle Soudy

Christelle Soudy
Senior research scientist at The Francis Crick Institute (synthetic organic chemistry)

Dr Jemima Thomas

Jemima Thomas

Dr Jemima Thomas
CRUK Convergence Science Centre research associate in multidisciplinary cancer therapeutics

Dr Archie Wall

Dr Archie Wall

Dr Archie Wall
EPSRC research associate in chemical biology, with Dr Anna Barnard

Dr Josephine Walton

Josephine Walton

Dr Josephine Walton
Myricx research scientist, cancer cell biology (60)

Dr Zhangping Xiao

Zhangping Xiao

Dr Zhangping Xiao
BBSRC research associate, towards novel inhibitors of hedgehog acyltransferase (62, 69)


PhD students

Cyrille Koundé

Cyrille Kounde

Cyrille Koundé
4th year GSK/EPSRC CASE PhD student, next generation PROTACs (41, 42)

Leran Zhang

Leran Zhang

Leran Zhang
4th year CRUK PhD student, unlocking the KLK activome in drug-resistant cancer (43-45)

Roxani Nikoloudaki

Roxani Nikoloudaki

Roxani Nikoloudaki
4th year ICB/Nestlé PhD student, new chemical probes for GPCRs involved in appetite regulation (36)

Henry Benns

Henry Benns

Henry Benns
4th year ICB PhD student, redox regulation of signalling in Toxoplasma gondii (46)

Simeon Draganov

Simeon Draganov

Simeon Draganov
4th year ICB PhD student, chemical proteomics of poly ADP ribosylation in inflammation (47, 61)

Ana Losada de la Lastra

Ana Losada de la Lastra

Ana Losada de la Lastra
4th year CRUK PhD, targeting protein acylation in cancer (50)

Miruna Androniciuc

Miruna Androniciuc

Miruna Androniciuc
4th year Imperial/Crick PhD, understanding Wnt acylation in development and disease (48)

Emma Couves

Emma Couves

Emma Couves
4th year CRUK PhD, structural biology/pharmacological modulation of the membrane attack complex (30)

Joe Tuersley

Joe Tuersley

Joe Tuersley
4th year PhD, pharmacological prevention of snake venom cytotoxicity (51)

Josh Linfoot

Josh Linfoot

Josh Linfoot
3rd year Syngenta EPSRC CASE PhD, metabolic pathways for pesticides (53)

Delia Brustur

Delia Brustur

Delia Brustur
3rd year PhD, immunomodulation in metastatic cancer using covalent fragment drug discovery

Sarah Hassan

Sarah Hassan

Sarah Hassan
3rd year President's Scholar ICB CDT PhD, protein prenylation in cancer

Qisi Zhang

Qisi Zhang

Qisi Zhang
3rd year ICB CDT PhD, PROTACs for conditional protein degradation

Robert Gray

Robert Gray

Robert Gray
3rd year Crick/Imperial clinical fellow, lipid metabolism in tuberculosis (38)

Michael Gruet

Michael Gruet

Michael Gruet
3rd year CRUK/EPSRC PhD student, PARP chemical biology (55)

Tom Jackson

Tom Jackson

Tom Jackson
3rd year ICB CDT PhD, photoswitchable peptide libraries (56, 57)

Jack Williams

Jack Williams

Jack Williams
3rd year Crick/Imperial joint PhD, cyclic peptides as chemical probes (56)

Chotima Seripracharat

Chotima

Chotima Seripracharat
2nd year PhD, Royal Thai Government, probe synthesis & identifying target of necroptosis inhibitors

Ammar Ahmed

Ammar Ahmed

Ammar Ahmed
2nd year PhD, synthesis and development of peptide inhibitors

James Zhang

James Zhang

James Zhang
2nd year PhD, CRUK Convergence Centre, NMT as a cancer target (63)

Vincent Saverat

Vincent Saverat

Vincent Saverat
2nd year PhD + MRes, ICB and Merck Sharp & Dohme CDT, developing novel biofunctional probes (64)

Frederic Buemi

Frederic Buemi

Frederic Buemi
2nd year PhD student, hydrolytic enzymes driving colorectal cancer development (65)

Zuzanna Jablonska

Zuzanna Jablonska

Zuzanna Jablonska
2nd year PhD student, BHF Centre, new therapeutic targets in ischemic heart disease (66)

Shreyas Bhatt

Shreyas Bhatt

Shreyas Bhatt
2nd year ICB CDT PhD, Gut-on-a-chip 4.0 (34, 35, 72)

Matt White

Matt White

Matt White
1st year CRUK/ICB PhD student, chemical proteomics and mechanisms of senescence (73)

Thomas Maher

Thomas Maher

Thomas Maher
1st year ICB CDT PhD student, development of probes to investigate G4 interacting proteins (74, 75)

Amina Nigmatulina

Amina Nigmatulina

Amina Nigmatulina
1st year PhD, chemical biology of biomolecule condensates

Shradda Vadodaria

Shradda Vadodaria

Shradda Vadodaria
1st year ICB CDT PhD student, covalent inhibition of a small GTPase

Gaseitsiwe Lame Senatla

Gaseitsiwe Lame Senatla

Gaseitsiwe Lame Senatla
1st year PhD student, Botswana Government scholar, inhibitors of hedgehog acyltransferase (62, 69)

Abigail Iles

Abigail Iles

Abigail Iles
1st year EPSRC/MSD ICB CDT PhD student, proximity-based drug-target identification (39, 76)

Amrita Date

Amrita Date

Amrita Date
1st year PhD student, President's Scholar, target profiling of hDM2 inhibitors (with Anna Barnard)


MRes in Drug Discovery and Development students

Beatrice Bizzotto

Beatrice Bizzotto

Beatrice Bizzotto
Small molecule inhibition of a small GTPase (14, 54)

Fabiana Ferreira Duarte

Fabiana Ferreira Duarte

Fabiana Ferreira Duarte
Novel inhibitors of necroptosis (39, 58)

Yaru Meng

Yaru Meng

Yaru Meng
Novel protease chemical probes for imaging and diagnostics

Aaron Mothersole

Aaron Mothersole

Aaron Mothersole
Novel treatments for Visceral Leishmaniasis (67)

Olivia Ramsay

Olivia Ramsay

Olivia Ramsay
Deciphiring the mode of action of NMT inhibitors (60)

Haozhe Xiao

Haozhe Xiao

Haozhe Xiao
Synthesis of novel bifunctionals

Minao Zhang

Minao Zhang

Minao Zhang
Towards novel inhibitors of hedgehog acyltransferase (62, 69)


Other members

Sharlin Patel

Sharlin Patel

Sharlin Patel
PhD student, writing up

Joshua Hope

Joshua Hope

Joshua Hope
4th year Crick/Imperial PhD, structural characterisation of the retroviral preintegration complex

Dr Marc Morgan

Marc Morgan

Dr Marc Morgan
Protein Crystallography Facility Manager

Dr Rishi Shah

Rishi Shah

Dr Rishi Shah
Visiting researcher, GlaxoSmithKline, PROTAC development

Anna Kukushkina

Anna Kukushkina

Anna Kukushkina
MSci student, disruption of a small GTPase (14)

Minqi Pan

Minqi Pan

Minqi Pan
MSci student, towards novel inhibitors of hedgehog acyltransferase (62, 69)


Alumni

Postdoctoral researchers: 2008: Sasala Wickramasinghe. 2010: Lucia de la Riva Perez. 2011: Dmitry Stetsenko, Vicki Barker, Matt Selby, Ute Brassat. 2012: Will Heal, Victor Goncalves. 2013: Victoria Albrow, Mark Rackham, Zhiyong Yu. 2014: Antonio Konitsiotis, Jennie Hutton. 2015: Goska Broncel, Soo Mei Chee, Kalesh. 2017: Rhiannon Beard, Julia Morales Sanfrutos, Markus Ritzefeld, Inma Perez Dorado. 2018: Remi Serwa, Charlotte Sutherell, Chiara Recchi, Chiara Fabbro. 2019: Aurélien Godinat, Anna Neodo, Scott Lovell, Marc Baggelaar. 2020: Monica Faronato, Tom Lanyon-Hogg. 2021: Ateequllah Hayat, Andrea Goya Grocin, Montse Tersa, Jennie Hutton, Ayesha Tejura (RA), Jasmine Bickel, Andrii Gorelik.

PhD students: 2009: Panumart Thongyoo. 2010: Gillian Rosenberg. 2011: Jemima Thomas, Tam Dang. 2012: Tayo Olaleye, Lucy Rayner, Alex Berry, Jenny Frueh. 2013: Megan Wright, Manue Thinon. 2014: Chris Douse. 2015: Naoko Masumoto, Paulina Ciepla, Tom Charlton, James Clulow, Andy Bell. 2016: Louis Perdios, Siak Lim, Lisa Storck Saha, Rhiannon Beard, Jenny Ward, Ernie So. 2017: Yunyun Sun, Mostafa Jamshidiha, Greg Craven. 2018: Wenye Zhao, Roman Fedoryshchak, Foteini Tzakoniati, Shao-Ju (Ryan) Lu. 2019: Jessica Shen, Charlie Saunders, Theo Flack, Mladen Stojanovic, Scott Lovell, Eloise Morecroft, Will Joyce, Anja Schlott, Gregor Lueg. 2020: Jasmine Bickel, Kate Hadavizadeh, Nattawadee Panyain, Andrea Goya Grocin, Miha Homsak, Ryan Howard, Cassandra Kennedy.

MRes students: 2008: Pinar Tulay, Martyna Snopek, Kavita Ramji. 2009: Antoine Delmotte. 2010: Kim Williams, Lucy Esteve, Janet Tsang. 2011: Dani Monteil. 2012: Tiffany Teng, Nino Gaphrindashivili. 2013: Liji Huang, George Bodakh, June Lim, Xiaoyi Wang, Eric Lee. 2014: Yuchen Zhao. 2015: Larissa See, Runzhong Fu, Jason Mak, Sandi Botonjic, Giovanna Morsiani. 2016: Juan Cuadrado, Lerui Guo, Zuzana Hodakova, Miriam Lyons, Niall McLoughlin, Sebastian Soh, Congyi Xu, Handa Zhang. 2017: Rania Al Janabi, Daniel Fernandez Llaneza, Isabella Kaczmarczyk, Sebastian Oehler, Carine Lim, Leran Zhang, Chiara Cecconello. 2018: Irphane Ariff, Sofia Chalkiadaki, Declan Cook, Nicole Deacon-Smith, Sarah Hassan, Kai Hove, Caitlin Jie, Sofia Lachiondo, Bowen Ma, Pasin Mapaisansin, Balazs Pogranyi, Xinzhu Wang. 2019: Billy Baxter, M. Juncal Calvo, Jonathan Davies, Leigh-Anne Gavin, Arzish Haqqee, Thomas Jackson, Callum Johnston, Javier Molina-Bermejo, Jingxing Qiu, Tilly Shackley, Ceire Wincott, Jinwang Yuan. 2020: Debraj Chowdhury, Amrita Date, Lisa Dollhopf, Mathias Fagbemi, Jeff Guo, Ming Huang, Qinxue Kong, Yuxin Liu, Nelli Morgulchik, Nikitas Ostrovitsa, Esther Perez-Barreiro, Panagiota Sarri, Emilia Taylor, Ayesha Tejura, Ioanna Thanasi, Pinqi Wang. 2021: Konstantina Arvaniti, Audrey Dausse, Matthew Dooley, Anusha Gupta, Abigail Iles, Aristo Kong, Caitlin Leo, Xiwen Ma, Amina Nigmatulina, Max Phillips, Jonathan Rockman, Gaseitsiwe Lame Senatla, David Sharp, Shradda Vadodaria, Xinyue Zhang, Peihao Zhao.

Undergraduate project/placement students: 2006: Helen Mcleod. 2007: Will Tomlinson, Katherine Elvira, Camille Bonomelli. 2008: James Sudlow. 2009: Irvine Howson, Vlad Turek, Sara Bessin. 2010: Aled Williams, Amanda Cheung, Sascha Yousefi, Genshi Chen. 2011: Machi Panteli, Brian Wilson, Timo Voelker, Wenlin Zhang, Nina Vrielink, Julia Gonzales Hernandes, Sibyl Sheppard. 2012: Enrico Fantoni, Jenny  Mizen, Solene Batut, Klaudia Cybulska, Boon Kiat Lee. 2013: Wai Peng Leong, Alice Huynh, Ben Chappell, Sabrina Maas, Chrystalla Constantinou, Will Whitehurst, Saphia Matthew. 2014: Olivia Boyd, James Davies, Xavier Wezen, Shuang Liu, Wouter Mooij, Niall McLoughlin. 2015: Tiffany Chan, Shuang Liu, Markus Artelsmair, Joel Fauser. 2016: Yuen Chow, Michelle Tan, Jenny Samphire, Suk Tan, Annina Burhop, Edward Ou, Alex Bakker, Christine Wu. 2017: Aditya Raymond Thawani, Rhian Hendley, Ana Losada de la Lastra, Dongxun Lyu, Angela Sun 2019: Stef Bannink, Edward Will, Jianjun (JJ) Ren, Alana Dastous, Camilla Ferro. 2020: Tristan Kovacic, Joshua Newington. 2021: Yongyin (Dorene) Chen, Yicheng Wang.

Visiting researchers: 2015: Dr Kasia Blewska (Lodz, COST network), Dany Pechalrieu (Toulouse, COST network). 2016: Daniela Glatzova (University of Prague, RSC mobility award). 2018: Wenhua Chen (CSC Scholarship), Elena De Vita (DKFZ, German Cancer Research Center). 2019: Michael Baek (University of Copenhagen). 2020: Jing Han (Institute of Chemistry, Chinese Academy of Sciences), Danai Kati (UCL). 2021: Dr María Maneiro Rey (Xunta de Galicia Fellow).


Collaborating labs and organisations

1. Peter O'Hare (Virology); 2. The Francis Crick Institute; 3. Tony Magee (NHLI); 4. Pfizer Neusentis; 5. Medicines for Malaria Venture; 6. Imperial Innovations; 7. Matilda Katan (UCL); 8. Paul French (Laser Physics); 9. Beata Wojciak-Stothard (Medicine); 10. Gad Frankel (Molecular Microbiology); 11. Tony Gee (KCL); 12. Colin Turnbull (Plant Physiology); 13. David Mann (Life Sciences); 14. Ernesto Cota (Structural Biology); 15. Institute of Cancer Research; 16. David Klug (Chemistry); 17. Reiko Tanaka (Bioengineering); 18. Syngenta; 19. Alan Armstrong (Chemistry); 20. Jamie Scott, Jeffrey Johannes (AstraZeneca); 21. Oscar Ces (Chemistry); 22. Jake Baum (Parasitology); 23. Xiaodong Zhang (Structural Biology); 24. Chiara Recchi (Oncology); 25. Keith Willison (Chemistry); 26. Hani Gabra (Oncology); 27. Tony Holder (Crick); 28. Dinis Calado (Crick); 29. Anna Barnard (Chemistry); 30. Doryen Bubeck (Structural Biology); 31. Charlotte Dodson (Biophysics); 32. Edgar Deu (Crick); 33. Alex Lyons (Medicine, NHLI); 34. Gary Frost (Medicine); 35. Aylin Hanyaloglu (Medicine); 36. Nestlé; 37. Susana Godinho (The Barts Cancer Institute, London); 38. Luiz Pedro Carvalho (Crick); 39. Avinash Shenoy (Microbiology); 40. Genentech; 41. John Harling (GSK); 42. Marcel Muelbaier (Cellzome/GSK); 43. Eric Aboagye (Surgery and Cancer); 44. Charlotte Bevan (Surgery and Cancer); 45. Hani Gabra (Surgery and Cancer); 46. Matt Child (Life Sciences); 47. Pete DiMaggio (Chemical Engineering); 48. Jean-Paul Vincent (Crick); 49. Evgen Pharma; 50. Julian Downward (Crick); 51. Vania Braga (Medicine); 52. Heptares; 53. Alan Spivey (Chemistry); 54. Jim Norman (CRUK, Beatson Institute, Glasgow); 55. Hector Keun (Surgery and Cancer); 56. Louise Walport (Crick); 57. Matthew Fuchter (Chemistry); 58. Rui Moreira, Cecília M. P. Rodrigues (Universidade de Lisboa); 59. Iain McNeish (Surgery and Cancer); 60. Myricx Pharma Ltd; 61. Dorian Haskard (Medicine); 62. Christian Siebold (Oxford); 63. Lou Chesler (ICR); 64. Mark Rackham (MSD); 65. Rachael Barry (Medicine); 66. Michela Noseda (Medicine); 67. Ben Perry (DNDi); 68. Andrew Edwards (Medicine); 69. Tom Lanyon-Hogg (Oxford); 70. David Gray (Dundee); 71. Steve Matthews (Structural Biology); 72. Joshua Edel (Chemistry); 73. Jesús Gil (Medicine); 74. Ramón Vilar Compte (Chemistry); 75. Marco Di Antonio (Chemistry); 76. James Bull (Chemistry).