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Citation

BibTex format

@article{Lovell:2019:10.1002/9781118970195.ch5,
author = {Lovell, S and Sutherell, CL and Tate, EW},
doi = {10.1002/9781118970195.ch5},
pages = {127--158},
title = {Chemical probes for proteins and networks},
url = {http://dx.doi.org/10.1002/9781118970195.ch5},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Chemical probes are small molecules with well-defined, selective biological activity and good physiochemical properties and have become important tools for probing fundamental biology and disease. After outlining the breadth of applications in the field of chemical proteomics, this chapter describes two key technologies applied within the group: metabolically incorporated probes for global profiling of protein networks and tagged probes for target identification and profiling. Despite the variety of uses of chemical probes, there are important common features regarding probe design, validation, and application. The exemplars cover the use of metabolically incorporated chemical probes for the global profiling of lipidated protein networks and probes to aid the unbiased identification of the targets of small molecules. The chapter outlines a typical protocol for an experimental setup commonly used in the lab with the N-myristoylation metabolic probe YnMyr.
AU - Lovell,S
AU - Sutherell,CL
AU - Tate,EW
DO - 10.1002/9781118970195.ch5
EP - 158
PY - 2019///
SP - 127
TI - Chemical probes for proteins and networks
UR - http://dx.doi.org/10.1002/9781118970195.ch5
ER -