@article{Flack:2019:10.1021/acs.orglett.9b01115,
author = {Flack, T and Romain, C and White, A and Haycock, P and Barnard, A},
doi = {10.1021/acs.orglett.9b01115},
journal = {Organic Letters},
pages = {4433--4438},
title = {Design, synthesis and conformational analysis of oligobenzanilides as multi-facial alpha-helix mimetics},
url = {http://dx.doi.org/10.1021/acs.orglett.9b01115},
volume = {21},
year = {2019}
}

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TY  - JOUR
AB  - The design, synthesis, and conformationalanalysis of an oligobenzanilide helix mimetic scaffold capableof simultaneous mimicry of two faces of an α-helix is reported.The synthetic methodology provides access to diversemonomer building blocks amenable to solid-phase assemblyin just four synthetic steps. The conformational flexibility ofmodel dimers was investigated using a combination of solidand solution state methodologies supplemented with DFTcalculations. The lack of noncovalent constraints allows forsignificant conformational plasticity in the scaffold, thuspermitting it to successfully mimic residues i, i+2, i+4, i+6, i+7, and i+9 of a canonical α-helix.
AU  - Flack,T
AU  - Romain,C
AU  - White,A
AU  - Haycock,P
AU  - Barnard,A
DO  - 10.1021/acs.orglett.9b01115
EP  - 4438
PY  - 2019///
SN  - 1523-7052
SP  - 4433
TI  - Design, synthesis and conformational analysis of oligobenzanilides as multi-facial alpha-helix mimetics
T2  - Organic Letters
UR  - http://dx.doi.org/10.1021/acs.orglett.9b01115
UR  - https://pubs.acs.org/doi/10.1021/acs.orglett.9b01115
UR  - http://hdl.handle.net/10044/1/71702
VL  - 21
ER  - 

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