@article{Azzarito:2016:10.1002/cbic.201500504,
author = {Azzarito, V and Rowell, P and Barnard, A and Edwards, TA and Macdonald, A and Warriner, SL and Wilson, AJ},
doi = {10.1002/cbic.201500504},
journal = {Chembiochem},
pages = {768--773},
title = {Probing Protein Surfaces: QSAR Analysis with Helix Mimetics},
url = {http://dx.doi.org/10.1002/cbic.201500504},
volume = {17},
year = {2016}
}

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TY  - JOUR
AB  - α-Helix-mediated protein–protein interactions (PPIs) are important targets for small-molecule inhibition; however, generic approaches to inhibitor design are in their infancy and would benefit from QSAR analyses to rationalise the noncovalent basis of molecular recognition by designed ligands. Using a helix mimetic based on an oligoamide scaffold, we have exploited the power of a modular synthesis to access compounds that can readily be used to understand the noncovalent determinants of hDM2 recognition by this series of cell-active p53/hDM2 inhibitors.
AU  - Azzarito,V
AU  - Rowell,P
AU  - Barnard,A
AU  - Edwards,TA
AU  - Macdonald,A
AU  - Warriner,SL
AU  - Wilson,AJ
DO  - 10.1002/cbic.201500504
EP  - 773
PY  - 2016///
SN  - 1439-7633
SP  - 768
TI  - Probing Protein Surfaces: QSAR Analysis with Helix Mimetics
T2  - Chembiochem
UR  - http://dx.doi.org/10.1002/cbic.201500504
VL  - 17
ER  - 

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