@article{Cordero:2007:10.1016/j.jchromb.2006.12.021,
author = {Cordero, R and Paterson, S},
doi = {10.1016/j.jchromb.2006.12.021},
journal = {J Chromatogr B Analyt Technol Biomed Life Sci},
pages = {423--431},
title = {Simultaneous quantification of opiates, amphetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC-MS.},
url = {http://dx.doi.org/10.1016/j.jchromb.2006.12.021},
volume = {850},
year = {2007}
}

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TY  - JOUR
AB  - A method is described for the simultaneous identification and quantification of opiates, amphetamines, cocainics, diazepam and nordiazepam from one hair extract (typically 10-50mg hair). After decontamination by washing with shampoo, dichloromethane, isopropanol and acetone, drugs were extracted using 0.1M HCl followed by SPE clean-up using mixed-mode extraction cartridges. The SPE extracts were submitted to a two-step derivatisation using MBTFA and MSTFA+1% TCMS and analysis was performed by GC-MS using both SIM and scan modes. Four deuterated standards were used to monitor 14 compounds. The limit of quantification was the total drug detected from the sample. This was 5 ng for amphetamines and 10 ng for remaining drugs which is equivalent to 0.1 and 0.2 ng/mg from a 50mg sample. Standard curves for the range 5-400 ng total drug concentration for all drugs had regression coefficients greater than 0.98. An authentic hair sample was used to validate the method and gave R.S.D.s <25% for both inter and intra-day reproducibility. The results of the analysis of hair taken from four patients attending a drug treatment clinic and six hair samples including head hair, pubic hair, axial hair and beard taken at post-mortem are presented.
AU  - Cordero,R
AU  - Paterson,S
DO  - 10.1016/j.jchromb.2006.12.021
EP  - 431
PY  - 2007///
SN  - 1570-0232
SP  - 423
TI  - Simultaneous quantification of opiates, amphetamines, cocaine and metabolites and diazepam and metabolite in a single hair sample using GC-MS.
T2  - J Chromatogr B Analyt Technol Biomed Life Sci
UR  - http://dx.doi.org/10.1016/j.jchromb.2006.12.021
UR  - https://www.ncbi.nlm.nih.gov/pubmed/17210273
VL  - 850
ER  - 

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