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@article{Wu:2019:10.1364/BOE.10.002457,
author = {Wu, P-J and Masouleh, MI and Paterson, C and Dini, D and Török, P and Overby, DR and Kabakova, IV},
doi = {10.1364/BOE.10.002457},
journal = {Biomedical Optics Express},
pages = {2457--2466},
title = {Detection of proteoglycan loss from articular cartilage using Brillouin microscopy, with applications to osteoarthritis},
url = {http://dx.doi.org/10.1364/BOE.10.002457},
volume = {10},
year = {2019}
}
TY - JOUR
AB - The degeneration of articular cartilage (AC) occurs in osteoarthritis (OA), which is a leading cause of pain and disability in middle-aged and older people. The early disease-related changes in cartilage extra-cellular matrix (ECM) start with depletion of proteoglycan (PG), leading to an increase in tissue hydration and permeability. These early compositional changes are small (<10%) and hence difficult to register with conventional non-invasive imaging technologies (magnetic resonance and ultrasound imaging). Here we apply Brillouin microscopy for detecting changes in the mechanical properties and composition of porcine AC. OA-like degradation is mimicked by enzymatic tissue digestion, and we compare Brillouin microscopy measurements against histological staining of PG depletion over varying digestion times and enzyme concentrations. The non-destructive nature of Brillouin imaging technology opens new avenues for creating minimally invasive arthroscopic devices for OA diagnostics and therapeutic monitoring.
AU - Wu,P-J
AU - Masouleh,MI
AU - Paterson,C
AU - Dini,D
AU - Török,P
AU - Overby,DR
AU - Kabakova,IV
DO - 10.1364/BOE.10.002457
EP - 2466
PY - 2019///
SN - 2156-7085
SP - 2457
TI - Detection of proteoglycan loss from articular cartilage using Brillouin microscopy, with applications to osteoarthritis
T2 - Biomedical Optics Express
UR - http://dx.doi.org/10.1364/BOE.10.002457
UR - http://hdl.handle.net/10044/1/70296
VL - 10
ER -