The Network aims to promote multi-disciplinary approaches to address challenging vaccine-related questions. This page contains a curated list of publications that highlight high-impact and collaborative approaches.
@article{Winskill:2017:10.1136/bmjgh-2016-000090,
author = {Winskill, P and Walker, P and Griffin, J and Ghani, A},
doi = {10.1136/bmjgh-2016-000090},
journal = {BMJ Global Health},
title = {Modelling the cost-effectiveness of introducing the RTS,S malaria vaccine relative to scaling up other malaria interventions in sub-Saharan Africa},
url = {http://dx.doi.org/10.1136/bmjgh-2016-000090},
volume = {2},
year = {2017}
}
TY - JOUR
AB - Objectives: To evaluate the relative cost-effectiveness of introducing the RTS,S malaria vaccine in sub-Saharan Africa compared with further scale-up of existing interventions.Design: A mathematical modelling and cost-effectiveness study.Setting: Sub-Saharan Africa.Participants: People of all ages.Interventions: The analysis considers the introduction and scale-up of the RTS,S malaria vaccine and the scale-up of long lasting insecticide treated bed nets (LLINs), indoor residual spraying (IRS) and seasonal malaria chemoprevention (SMC).Main outcome measure: The number of Plasmodium falciparum cases averted in all age groups over a ten year period.Results: Assuming access to treatment remains constant, increasing coverage of LLINs was consistently the most cost-effective intervention across a range of transmission settings and was found to occur early in the cost-effectiveness scale-up pathway. IRS, RTS,S and SMC entered the cost-effective pathway once LLIN coverage had been maximised. If non-linear production functions are included to capture the cost of reaching very high coverage, the resulting pathways become more complex and result in selection of multiple interventions.Conclusions: RTS,S was consistently implemented later in the cost-effectiveness pathway than the LLINs, IRS and SMC but was still of value as a fourth intervention in many settings to reduce burden to the levels set out in the international goals.
AU - Winskill,P
AU - Walker,P
AU - Griffin,J
AU - Ghani,A
DO - 10.1136/bmjgh-2016-000090
PY - 2017///
SN - 2059-7908
TI - Modelling the cost-effectiveness of introducing the RTS,S malaria vaccine relative to scaling up other malaria interventions in sub-Saharan Africa
T2 - BMJ Global Health
UR - http://dx.doi.org/10.1136/bmjgh-2016-000090
UR - http://hdl.handle.net/10044/1/43332
VL - 2
ER -