@article{Lightman:2015:10.1136/annrheumdis-2014-205571,
author = {Lightman, S and Taylor, SRJ and Bunce, C and Longhurst, H and Lynn, W and Moots, R and Stanford, M and Tomkins-Netzer, O and Yang, D and Calder, VL and Haskard, DO},
doi = {10.1136/annrheumdis-2014-205571},
journal = {Annals of the Rheumatic Diseases},
pages = {1138--1144},
title = {Pegylated interferon-alpha-2b reduces corticosteroid requirement in patients with Behcet's disease with upregulation of circulating regulatory T cells and reduction of Th17},
url = {http://dx.doi.org/10.1136/annrheumdis-2014-205571},
volume = {74},
year = {2015}
}

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TY  - JOUR
AB  - Objective To determine whether the addition of 26weeks of subcutaneous peginterferon-α-2b could reduce the requirement for systemic corticosteroids and conventional immunosuppressive medication in patients with Behçet's disease (BD).Methods We conducted a multicentre randomised trial in patients with BD requiring systemic therapy. Patients were randomised to 26weeks of peginterferon-α-2b in addition to their standard care or to standard care only and followed 6-monthly for 3years with BD activity scores and quality of life questionnaires. Patients at one centre had blood taken to measure regulatory T cells (Tregs) and Th17 cells.Results 72 patients were included. At months 10–12, while among the entire patient population there was no difference in the corticosteroid dose or immunosuppression use between the treatment groups (adjusted OR 1.04, 95% CI 0.34 to 3.19), post hoc analysis revealed that in patients who were on corticosteroids at baseline the corticosteroid requirement was significantly lower in the peginterferon-α-2b (6.5 (5–15) mg/day) compared with the non-interferon group (10 (8.25–16.5) mg/day, p=0.039). Furthermore, there was a trend towards an improved quality of life that became significant by 36months (p=0.008). This was associated with a significant rise in Tregs and a decrease in Th17 cells which was still present at 1year and 6months after the interferon was stopped. The safety profile was similar with adverse events in 10% in both groups.Conclusions The addition of peginterferon-α-2b to the drug regime of BD patients did not significantly reduce their corticosteroid dose required at 1year. However, in those on corticosteroids at baseline post hoc analysis demonstrated that the addition of peginterferon-α-2b did result in a significant reduction in corticosteroid dose with a significantly improved quality of life and trend to reduce other required immunosuppressive agents. This effect
AU  - Lightman,S
AU  - Taylor,SRJ
AU  - Bunce,C
AU  - Longhurst,H
AU  - Lynn,W
AU  - Moots,R
AU  - Stanford,M
AU  - Tomkins-Netzer,O
AU  - Yang,D
AU  - Calder,VL
AU  - Haskard,DO
DO  - 10.1136/annrheumdis-2014-205571
EP  - 1144
PY  - 2015///
SN  - 0003-4967
SP  - 1138
TI  - Pegylated interferon-alpha-2b reduces corticosteroid requirement in patients with Behcet's disease with upregulation of circulating regulatory T cells and reduction of Th17
T2  - Annals of the Rheumatic Diseases
UR  - http://dx.doi.org/10.1136/annrheumdis-2014-205571
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000354371200028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://ard.bmj.com/content/74/6/1138
UR  - http://hdl.handle.net/10044/1/18383
VL  - 74
ER  - 

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