@article{Vilar:2020:10.1039/d0dt00930j,
author = {Vilar, R and Torres, Huerta A and Chan, TG and White, AJP},
doi = {10.1039/d0dt00930j},
journal = {Dalton Transactions},
pages = {5939--5948},
title = {Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles},
url = {http://dx.doi.org/10.1039/d0dt00930j},
volume = {49},
year = {2020}
}

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TY  - JOUR
AB  - Metal-based anion receptors have several important applications in sensing, separation and transport of negatively charged species. Amongst these receptors, di-zinc(II) complexes are of particular interest for the recognition of oxoanions, in particular phosphate derivatives. Herein we report the synthesis of a di-zinc(II) receptor and show that it has high affinity and selectivity for bisphosphonates such as alendronate and etidronate – which are used to treat a number of skeletal disorders as well as showing interesting anticancer properties. The binding mode of the di-zinc(II) receptor with alendronate and etidronate has been unambiguously established by single crystal X-ray crystallography. In addition, by modifying the backbone of the receptor, we show that the drug-loaded receptor can be attached onto gold nanoparticles as potential drug-delivery vehicles.
AU  - Vilar,R
AU  - Torres,Huerta A
AU  - Chan,TG
AU  - White,AJP
DO  - 10.1039/d0dt00930j
EP  - 5948
PY  - 2020///
SN  - 1477-9226
SP  - 5939
TI  - Molecular recognition of bisphosphonate-based drugs by di-zinc receptors in aqueous solution and on gold nanoparticles
T2  - Dalton Transactions
UR  - http://dx.doi.org/10.1039/d0dt00930j
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2020/DT/D0DT00930J#!divAbstract
UR  - http://hdl.handle.net/10044/1/78158
VL  - 49
ER  - 

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