We are pleased to announce that the following members of staff will be undertaking attachments at the Crick:
Wendy Barclay (Department of Medicine) and Peter Openshaw (NHLI) - Professors Barclay and Openshaw will be establishing an influenza hub at the Crick, bringing together experts in influenza virus research from Imperial and the Crick to create a group with expertise in molecular virology, immunology and respiratory disease. The aim is to develop an understanding of the molecular and cellular pathways that underlie disease, in order to guide future therapeutic interventions with confidence.
Morgan Beeby (Life Sciences) - Dr Beeby will be leading a group to undertake high‐resolution in situ visualization of the molecular machinery involved in infection and of the infection process in gastroenteritis. The group will use the Crick's state-of-the-art electron cryo-tomography facilities to visualise the molecular basis of secretion and to visualise infection, and it is hoped that the mechanistic insights into the molecular basis of infection by two important bacterial causes of gastroenteritis will ultimately form a foundation for translational development of therapeutic strategies.
Paul French (Physics) - The Photonics Group at Imperial is developing a multidimensional fluorescence imaging platform that provides quantitative fluorescent readouts of protein interactions, cellular metabolic processes and tissue matrix components implemented in optical instrumentation ranging from super-resolved microscopes and automated plate readers, through preclinical tomographic imaging of intact live disease models, to label-free clinical imaging and metrology (e.g. of cancer, heart disease and osteoarthritis). Professor French's satellite group will provide Crick scientists with access to cutting edge imaging technologies that are not commercially available, and will give the Imperial team access to world-leading biologists to enable them to better focus the technology development and beta test it at the Crick, potentially greatly aiding the demonstration of proof of concept of the technology and enhancing dissemination to the wider research community.
Cristina Lo Celso (Life Sciences) - Dr Lo Celso will be leading a group to build on work conducted at the College investigating the relationship between haematopoietic stem cells, leukaemia and their bone marrow microenvironment to identify the stem-cell stroma interactions associated with haematopoietic stem cell fate changes, and to test the cause-effect relationship of these interactions. The work undertaken at the Crick will use cutting-edge imaging technology and image analysis to address these currently challenging questions in stem-cell biology, drawing on the unique expertise of Crick researchers in mammalian cell biology.
Molly Stevens (Bioengineering) - Professor Stevens' satellite group at the Crick will be collaborating with Crick scientists in the exploration of materials for cell applications. Research areas will include using nanoneedle technology to investigate the role of T-cells, macrophages and dendritic cells in inducing specific patterns cytokines; and using cell/tissue engineering technology to address questions from across the spectrum of basic to more applied biology.
Ed Tate (Chemistry) - Professor Tate's group will be working on the development, validation and application of highly selective, functional, and novel chemical tools that open up new directions in cell and whole-organism biology. A particular focus is in understanding the full spectrum of protein targets of small molecule inhibitors and peptides/peptidomimetics at a quantitative level, with the objective of delivering well-validated tool molecules that enable new approaches in cell biology, and taking compounds into collaborative translational studies with the aim of validating targets and pathways for future drug discovery.
Gunnar Pruessner (Mathematics) - Dr Pruessner will be undertaking a year-long sabbatical to undertake research in the field of microtubules. The microtubule cytoskeleton provides a eukaryotic cell with structure and skeletal support, and with a network for cellular transport processes, and Dr Pruessner's research will focus on microtubule nucleation, microtubule dynamics, and the spatiotemporal regulation of these events, using sophisticated, field-theoretic techniques to analyse data, model the system and propose relevant experimental observables. Since microtubules are present at virtually every stage of the life cycle of a cell, this research has significant implications at a fundamental level, and because homologues exist across the living world, insights into the microbiology of microtubules may also translate to other areas.