@article{Laeremans:2018:10.1016/j.envint.2018.04.040,
author = {Laeremans, M and Dons, E and Avila-Palencia, I and Carrasco-Turigas, G and Orjuela, JP and Anaya, E and Cole-Hunter, T and de, Nazelle A and Nieuwenhuijsen, M and Standaert, A and Van, Poppel M and De, Boever P and Panis, LI},
doi = {10.1016/j.envint.2018.04.040},
journal = {ENVIRONMENT INTERNATIONAL},
pages = {82--90},
title = {Short-term effects of physical activity, air pollution and their interaction on the cardiovascular and respiratory system},
url = {http://dx.doi.org/10.1016/j.envint.2018.04.040},
volume = {117},
year = {2018}
}

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TY  - JOUR
AB  - Physical activity (PA) in urban environments may lead to increased inhalation of air pollutants. As PA and air pollution (AP) have respectively beneficial and detrimental effects on the cardiorespiratory system, the responses to these exposures can interact. Therefore, we assessed the short-term effects of PA, AP and their interaction on a set of subclinical cardiovascular and respiratory outcomes in a panel of healthy adults: heart rate variability (HRV), retinal vessel diameters, lung function and fractional exhaled nitric oxide (FeNO).One hundred twenty two participants measured their PA level and exposure to black carbon (BC), a marker of AP exposure, with wearable sensors during an unscripted week in three different seasons. The study was part of the PASTA project in three European cities (Antwerp: 41 participants, Barcelona: 41 participants, London: 40 participants). At the end of each measurement week, the health outcomes were evaluated. Responses to PA, BC and their interaction were assessed with mixed effect regression models. Separate models were used to account for a 2-h and 24-h time window.During the 2-h time window, HRV and lung function changed statistically significantly in response to PA (METhours) and logarithmic BC (%change). Changes in HRV marked an increased sympathetic tone with both PA (logarithmic LF/HF: +7%; p<0.01) and BC (logarithmic HF: −19%; p<0.05). In addition, PA provoked bronchodilation which was illustrated by a significant increase in lung function (FEV1: +15.63mL; p<0.05). While a BC %increase was associated with a significant lung function decrease (PEF: −0.10mL; p<0.05), the interaction indicated a potential protective effect of PA (p<0.05). We did not observe a response of the retinal vessel diameters. Most subclinical outcomes did not change in the 24-h time window (except for a few minor changes in LF/HF, FeNO and PEF).Our results on the separate and combined effects of short-term PA and
AU  - Laeremans,M
AU  - Dons,E
AU  - Avila-Palencia,I
AU  - Carrasco-Turigas,G
AU  - Orjuela,JP
AU  - Anaya,E
AU  - Cole-Hunter,T
AU  - de,Nazelle A
AU  - Nieuwenhuijsen,M
AU  - Standaert,A
AU  - Van,Poppel M
AU  - De,Boever P
AU  - Panis,LI
DO  - 10.1016/j.envint.2018.04.040
EP  - 90
PY  - 2018///
SN  - 0160-4120
SP  - 82
TI  - Short-term effects of physical activity, air pollution and their interaction on the cardiovascular and respiratory system
T2  - ENVIRONMENT INTERNATIONAL
UR  - http://dx.doi.org/10.1016/j.envint.2018.04.040
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000436573400010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/61811
VL  - 117
ER  - 

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