@article{Cole-Hunter:2017:10.1016/j.envint.2017.11.024,
author = {Cole-Hunter, T and de, Nazelle A and Donaire-Gonzalez, D and Kubesch, N and Carrasco-Turigas, G and Matt, F and Foraster, M and Martínez, T and Ambros, A and Cirach, M and Martinez, D and Belmonte, J and Nieuwenhuijsen, M},
doi = {10.1016/j.envint.2017.11.024},
journal = {Environment International},
pages = {247--259},
title = {Estimated effects of air pollution and space-time-activity on cardiopulmonary outcomes in healthy adults: A repeated measures study.},
url = {http://dx.doi.org/10.1016/j.envint.2017.11.024},
volume = {111},
year = {2017}
}

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TY  - JOUR
AB  - BACKGROUND: Exposure to air pollution is known to affect both short and long-term outcomes of the cardiopulmonary system; however, findings on short-term outcomes have been inconsistent and often from isolated and long-term rather than coexisting and short-term exposures, and among susceptible/unhealthy rather than healthy populations. AIMS: We aimed to investigate separately the annual, daily and daily space-time-activity-weighted effect of ambient air pollution, as well as confounding or modification by other environmental (including noise) or space-time-activity (including total daily physical activity) exposures, on cardiopulmonary outcomes in healthy adults. METHODS: Participants (N=57: 54% female) had indicators of cardiopulmonary outcomes [blood pressure (BP), pulse (HR) and heart rate variability (HRV {SDNN}), and lung function (spirometry {FEV1, FVC, SUM})] measured on four different mornings (at least five days apart) in a clinical setting between 2011 and 2014. Spatiotemporal ESCAPE-LUR models were used to estimate daily and annual air pollution exposures (including PM10, PMCoarse, but not Ozone {derived from closest station}) at participant residential and occupational addresses. Participants' time-activity diaries indicated time spent at either address to allow daily space-time-activity-weighted estimates, and capture total daily physical activity (total-PA {as metabolic-equivalents-of-task, METs}), in the three days preceding health measurements. Multivariate-adjusted linear mixed-effects models (using either annual or daily estimates) were adjusted for possible environmental confounders or mediators including levels of ambient noise and greenness. Causal mediation analysis was also performed separately considering these factors as well as total-PA. All presented models are controlled by age, height, sex and season. RESULTS: An increase in 5μg/m3 of daily space-time-activity-weighted PMCoarse exposure was statistically significantly associated with
AU  - Cole-Hunter,T
AU  - de,Nazelle A
AU  - Donaire-Gonzalez,D
AU  - Kubesch,N
AU  - Carrasco-Turigas,G
AU  - Matt,F
AU  - Foraster,M
AU  - Martínez,T
AU  - Ambros,A
AU  - Cirach,M
AU  - Martinez,D
AU  - Belmonte,J
AU  - Nieuwenhuijsen,M
DO  - 10.1016/j.envint.2017.11.024
EP  - 259
PY  - 2017///
SN  - 0160-4120
SP  - 247
TI  - Estimated effects of air pollution and space-time-activity on cardiopulmonary outcomes in healthy adults: A repeated measures study.
T2  - Environment International
UR  - http://dx.doi.org/10.1016/j.envint.2017.11.024
UR  - http://hdl.handle.net/10044/1/56552
VL  - 111
ER  - 

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