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Journal articleLemmer M, Inkpen MS, Kornysheva K, et al., 2016,
Unsupervised vector-based classification of single-molecule charge transport data
, Nature Communications, Vol: 7, Pages: 1-10, ISSN: 2041-1723The stochastic nature of single-molecule charge transport measurements requires collection of large data sets to capture the full complexity of a molecular system. Data analysis is then guided by certain expectations, for example, a plateau feature in the tunnelling current distance trace, and the molecular conductance extracted from suitable histogram analysis. However, differences in molecular conformation or electrode contact geometry, the number of molecules in the junction or dynamic effects may lead to very different molecular signatures. Since their manifestation is a priori unknown, an unsupervised classification algorithm, making no prior assumptions regarding the data is clearly desirable. Here we present such an approach based on multivariate pattern analysis and apply it to simulated and experimental single-molecule charge transport data. We demonstrate how different event shapes are clearly separated using this algorithm and how statistics about different event classes can be extracted, when conventional methods of analysis fail.
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Journal articleInkpen MS, Scheerer S, Linseis M, et al., 2016,
Oligomeric ferrocene rings
, Nature Chemistry, Vol: 8, Pages: 825-830, ISSN: 1755-4330Cyclic oligomers comprising strongly interacting redox-active monomer units represent an unknown, yet highly desirable class of nanoscale materials. Here we describe the synthesis and properties of the first family of molecules belonging to this compound category—differently sized rings comprising only 1,1′-disubstituted ferrocene units (cyclo[n], n = 5–7, 9). Due to the close proximity and connectivity of centres (covalent Cp–Cp linkages; Cp = cyclopentadienyl) solution voltammograms exhibit well-resolved, separated 1e– waves. Theoretical interrogations into correlations based on ring size and charge state are facilitated using values of the equilibrium potentials of these transitions, as well as their relative spacing. As the interaction free energies between the redox centres scale linearly with overall ring charge and in conjunction with fast intramolecular electron transfer (∼107 s−1), these molecules can be considered as uniformly charged nanorings (diameter ∼1–2 nm).
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Journal articleQiao L, Shougee A, Albrecht T, et al., 2016,
Oxide-coated silicon nanowire array capacitor electrodes in room temperature ionic liquid
, Electrochimica Acta, Vol: 210, Pages: 32-37, ISSN: 0013-4686Improved performance of Si nanowire arrays for capacitor electrodes in ionic liquid [Bmim][NTf2], is obtained by spin-on-doping the nanowires followed by hot, concentrated nitric acid oxidation. n- and p-type Si nanowire arrays are fabricated via a 2-step metal-assisted chemical etch process to increase the effective surface area. Spin-on-doping increases the doping density of the nanowires, enhancing the current by a factor of more than 3. The well-controlled HNO3 oxidation defines a thin, dense oxide layer on the Si nanowires increasing chemical stability, both expanding the electrochemical window and increasing the current further by a factor >2. Specific capacitances of 238 μF cm−2 (∼0.4 F g−1, 159 mF cm−3) and 404 μF cm−2 (∼0.7 F g−1, 269 mF cm−3) are obtained for n- and p-type Si nanowire arrays, respectively.
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Journal articleFraccari RL, Carminati M, Piantanida G, et al., 2016,
High-bandwidth detection of short DNA in nanopipettes.
, Faraday Discussions, ISSN: 1364-5498Glass or quartz nanopipettes have found increasing use as tools for studying the biophysical properties of DNA and proteins, and as sensor devices. The ease of fabrication, favourable wetting properties and low capacitance are some of the inherent advantages, for example compared to more conventional, silicon-based nanopore chips. Recently, we have demonstrated high-bandwidth detection of double-stranded (ds) DNA with microsecond time resolution in nanopipettes, using custom-designed electronics. The electronics design has now been refined to include more sophisticated control features, such as integrated bias reversal and other features. Here, we exploit these capabilities and probe the translocation of short dsDNA in the 100 bp range, in different electrolytes. Single-stranded (ss) DNA of similar length are in use as capture probes, so label-free detection of their ds counterparts could therefore be of relevance in disease diagnostics.
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Journal articleAlbrecht T, Godfrey D, Bannock JH, et al., 2016,
A robotic platform for high-throughput electrochemical analysis of chalcopyrite leaching
, Green Chemistry, Vol: 18, Pages: 1930-1937, ISSN: 1463-9262Cu extraction from chalcopyrite ores is typically a slow process that involves aggressive chemical reagents with significant environmental impact. Ionic liquids (IL) have been proposed as a potentially more benign solution, but the sheer number of IL variants complicates the search for the most efficient solvent systems. Here, we present an automated electrochemical platform that allows for screening of 180 and more leaching samples in parallel with minimal solvent consumption. In a proof-of-concept study, we screen 25 samples with different IL and water contents, and find two orders of magnitude difference in leaching performance within this array. The best performing system is then applied in a tank leaching configuration, with real-time electrochemical monitoring of Cu evolution in solution. All electrochemical data is found to be in excellent agreement with off-line ICP-AES data.
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Conference papershougee A, Konstantinou F, Albrecht T, et al., 2016,
Silicon nanowire arrays for high capacitance electrodes in room temperature ionic liquid electrolyte
, 229th ECS Meeting -
Journal articleAlbrecht T, Fraccari R, Ciccarella P, et al., 2016,
High-speed detection of DNA Translocation in Nanopipettes
, Nanoscale, Vol: 8, Pages: 7604-7611, ISSN: 2040-3372We present a high-speed electrical detection scheme based on a custom-designed CMOS amplifier which allows the analysis of DNA translocation in glass nanopipettes on a microsecond timescale. Translocation of different DNA lengths in KCl electrolyte provides a scaling factor of the DNA translocation time equal to p = 1.22, which is different from values observed previously with nanopipettes in LiCl electrolyte or with nanopores. Based on a theoretical model involving electrophoresis, hydrodynamics and surface friction, we show that the experimentally observed range of p-values may be the result of, or at least be affected by DNA adsorption and friction between the DNA and the substrate surface.
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Conference paperFraccari RL, Ciccarella P, Bahrami A, et al., 2016,
Probing DNA Translocations in Nanopipettes using High-Speed Detection Electronics
, 60th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 655A-655A, ISSN: 0006-3495 -
Journal articleVilar Compte R, Shivalingam A, Vysniauskas A, et al., 2016,
Trianguleniums as optical probes for G-quadruplexes: A photophysical, electrochemical and computational study
, Chemistry - A European Journal, Vol: 22, Pages: 4129-4139, ISSN: 0947-6539Nucleic acids can adopt non-duplex topologies such as G-quadruplexes in vitro. Yet it hasbeen challenging to establish their existence and function in vivo due to a lack of suitabletools. Recently, we identified the triangulenium compound DAOTA-M2 as a uniquefluorescence probe for such studies. This probe’s emission lifetime is highly dependent onthe topology of the DNA it interacts with opening up the possibility of carrying out live cellimaging studies. Herein we describe the origin of its fluorescence selectivity for Gquadruplexes.Cyclic voltammetry predicts that the appended morpholino groups can act asintra-molecular photo-induced electron transfer (PET) quenchers. Photophysical studies showthat a delicate balance between this effect and inter-molecular PET with nucleobases is key tothe overall fluorescence enhancement observed upon nucleic acid binding. We utilisedcomputational modelling to demonstrate a conformational dependence of intra-molecularPET. Finally, we performed orthogonal studies with a triangulenium compound where themorpholino groups were removed and demonstrate that this change inverts trianguleniumfluorescence selectivity from G-quadruplex to duplex DNA, thus highlighting the importanceof fine-tuning the molecular structure not only for target affinity but also for fluorescenceresponse.
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Conference paperShougee A, Konstantinou F, Albrecht T, et al., 2016,
Silicon nanowire arrays for high capacitance electrodes in room temperature ionic liquid electrolyte
, 229th ECS Meeting -
Journal articleNuttall P, Lee K, Ciccarella P, et al., 2016,
Single-Molecule Studies of Unlabeled Full-Length p53 Protein Binding to DNA.
, Journal of Physical Chemistry B, Vol: 120, Pages: 2106-2114, ISSN: 1520-6106p53 is an antitumor protein that plays an important role in apoptosis, preserving genomic stability and preventing angiogenesis, and it has been implicated in a large number of human cancers. For this reason it is an interesting target for both fundamental studies, such as the mechanism of interaction with DNA, and applications in biosensing. Here, we report a comprehensive study of label-free, full length p53 (flp53) and its interaction with engineered double-stranded DNA in vitro, at the single-molecule level, using atomic force microscopy (AFM) imaging and solid-state nanopore sensing. AFM data show that dimeric and tetrameric p53 bind to the DNA in a sequence-specific manner, confirming previously reported relative binding affinities. The statistical significance is tested using both the Grubbs test and stochastic simulations. For the first time, ultralow noise solid-state nanopore sensors are employed for the successful differentiation between bare DNA and p53/DNA complexes. Furthermore, translocation statistics reflect the binding affinities of different DNA sequences, in accordance with AFM data. Our results thus highlight the potential of solid-state nanopore sensors for single-molecule biosensing, especially when labeling is either not possible or at least not a viable option.
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Journal articleInkpen MS, White AJP, Albrecht T, et al., 2016,
Complexes comprising ‘dangling’ phosphorus arms and tri(hetero)metallic butenynyl moieties
, Journal of Organometallic Chemistry, Vol: 812, Pages: 145-150, ISSN: 1872-8561Trans-RuCl2(PP3)2 (1a) (PP3 = tris[2-(diphenylphosphino)ethyl]phosphine) was prepared by reaction of RuCl2(PPh3)3 with 2 eq. PP3. Through coordination of two potentially tetradentate ligands in a bidentate arrangement, four uncoordinated phosphine moieties remain readily available for subsequent reaction. This is demonstrated through their facile oxidation with hydrogen peroxide, providing trans-RuCl2(PP[Pdouble bond; length as m-dashO]2)2 (1b) (PP[Pdouble bond; length as m-dashO]2 = bis[2-(diphenylphosphine oxide)ethyl][2-(diphenylphosphino)ethyl]phosphine). Whilst chloride abstraction reactions from 1a appear slow (typical for trans dichlorides), cis-RuCl2(PP3) is shown to react rapidly with ethynylferrocene under ‘Dixneuf’ conditions (CH2Cl2, NaPF6, NEt3), providing the tri(hetero)metallic butenynyl complex [(PP3)Ru(η3–FcC3CHFc)]PF6 (2, Fc = ferrocenyl). The pendant groups of 1a-b offer great potential for future coordination studies (for example, to prepare mixed transition metal/lanthanide materials), whereby the facile synthetic route to 2 suggests a path towards examination of complex mixed-valence systems comprising multiple redox-active centres.
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Journal articleCheung KCM, Chen X, Albrecht T, et al., 2016,
Principles of a Single-Molecule Rectifier in Electrolytic Environment
, Journal of Physical Chemistry C, Vol: 120, Pages: 3089-3106, ISSN: 1932-7455The idea of gating the electrical current across a single-chain molecule, confined between and linking two electrodes in electrolytic solution, in order to achieve an asymmetric current–voltage plot, was first put forward and substantiated with a detailed theory by Kornyshev and Kuznetsov (ChemPhysChem, 2006), and Kornyshev, Kuznetsov, and Ulstrup (PNAS, 2006). However, not all aspects of that effect have been studied in those papers. Its experimental confirmation, published by Capozzi et al. (Nature Nanotech., 2015), enthused us to revisit that theory, extending it and exploring all the regimes of system operation. In this article we present such comprehensive analysis, which reveals a set of new features. An important finding is that the introduction of more refined models of the electric double layer (beyond linear response) results in stronger rectification effects, already for relatively dilute electrolyte concentrations. The theory equally applies to electrode systems with and without full electrochemical potential control and highlights important differences for these two scenarios, for example, with regard to the effect of electrode surface area.
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Journal articleInkpen MS, Du S, Hildebrand M, et al., 2015,
The unusual redox properties of fluoroferrocenes revealed through a comprehensive study of the haloferrocenes
, Organometallics, Vol: 34, Pages: 5461-5469, ISSN: 1520-6041We report the synthesis and full characterization of the entire haloferrocene (FcX) and 1,1′-dihaloferrocene (fcX2) series (X = I, Br, Cl, F; Fc = ferrocenyl, fc = ferrocene-1,1′-diyl). Finalization of this simple, yet intriguing set of compounds has been delayed by synthetic challenges associated with the incorporation of fluorine substituents. Successful preparation of fluoroferrocene (FcF) and 1,1′-difluoroferrocene (fcF2) were ultimately achieved using reactions between the appropriate lithiated ferrocene species and N-fluorobenzenesulfonimide (NFSI). The crude reaction products, in addition to those resulting from analogous preparations of chloroferrocene (FcCl) and 1,1′-dichloroferrocene (fcCl2), were utilized as model systems to probe the limits of a previously reported “oxidative purification” methodology. From this investigation and careful solution voltammetry studies, we find that the fluorinated derivatives exhibit the lowest redox potentials of each of the FcX and fcX2 series. This counterintuitive result is discussed with reference to the spectroscopic, structural, and first-principles calculations of these and related materials.
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Journal articleNguyen BN, Adrio LA, Albrecht T, et al., 2015,
Electronic structures of cyclometalated palladium complexes in the higher oxidation states
, Dalton Transactions, Vol: 44, Pages: 16586-16591, ISSN: 1477-9226The electronic and redox properties of a series of cyclometalated Pd complexes with oxidation states of +2, +3 and +4 were examined using a range of currently available spectroscopic and electrochemical techniques. Changes in metal–ligand bond lengths were established by X-ray crystallography and correctly predicted by DFT calculations, from which the frontier orbitals and partial atomic charges can be obtained. X-ray absorption spectroscopy (XAS) revealed interesting XANES features that suggest a synergistic relationship between metal–ligand interactions. The electrochemical study of the Pd(II) dimer was found to contain two sequential oxidative potentials indicative of a weak metal–metal interaction.
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Journal articleAlbrecht T, Inkpen MS, Lemmer M, et al., 2015,
New insights into single-molecule junctions using a robust, unsupervised approach to data collection and analysis
, Journal of the American Chemical Society, ISSN: 1520-5126 -
Journal articleMathwig K, Albrecht T, Goluch ED, et al., 2015,
Challenges of Biomolecular Detection at the Nanoscale: Nanopores and Microelectrodes
, Analytical Chemistry, Vol: 87, Pages: 5470-5475, ISSN: 1086-4377 -
Journal articlePitchford WH, Kim H-J, Ivanov AP, et al., 2015,
Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform
, ACS NANO, Vol: 9, Pages: 1740-1748, ISSN: 1936-0851 -
Journal articleLee DJO, Wynveen A, Albrecht T, et al., 2015,
Which way up? Recognition of homologous DNA segments in parallel and antiparallel alignments
, Journal of Chemical Physics, Vol: 142, ISSN: 1089-7690Homologous gene shuffling between DNA molecules promotes genetic diversity and is an important pathway for DNA repair. For this to occur, homologous genes need to find and recognize each other. However, despite its central role in homologous recombination, the mechanism of homology recognition has remained an unsolved puzzle of molecular biology. While specific proteins are known to play a role at later stages of recombination, an initial coarse grained recognition step has, however, been proposed. This relies on the sequence dependence of the DNA structural parameters, such as twist and rise, mediated by intermolecular interactions, in particular, electrostatic ones. In this proposed mechanism, sequences that have the same base pair text, or are homologous, have lower interaction energy than those sequences with uncorrelated base pair texts. The difference between the two energies is termed the “recognition energy.” Here, we probe how the recognition energy changes when one DNA fragment slides past another, and consider, for the first time, homologous sequences in antiparallel alignment. This dependence on sliding is termed the “recognition well.” We find there is a recognition well for anti-parallel, homologous DNA tracts, but only a very shallow one, so that their interaction will differ little from the interaction between two nonhomologous tracts. This fact may be utilized in single molecule experiments specially targeted to test the theory. As well as this, we test previous theoretical approximations in calculating the recognition well for parallel molecules against MC simulations and consider more rigorously the optimization of the orientations of the fragments about their long axes upon calculating these recognition energies. The more rigorous treatment affects the recognition energy a little, when the molecules are considered rigid. When torsional flexibility of the DNA molecules is introduced, we find excellent agreement between the
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Journal articleRutkowska A, Freedman KJ, Skalkowska J, et al., 2015,
Electrodeposition and bipolar effects in metallized nanopores and their use in the detection of insulin
, Analytical Chemistry, ISSN: 1086-4377 -
Journal articleInkpen MS, White AJP, Albrecht T, et al., 2014,
Avoiding problem reactions at the ferrocenyl-alkyne motif: a convenient synthesis of model, redox-active complexes for molecular electronics
, DALTON TRANSACTIONS, Vol: 43, Pages: 15287-15290, ISSN: 1477-9226 -
Journal articleJaprung D, Bahrami A, Nadzeyka A, et al., 2014,
SSB Binding to Single-stranded DNA Probed Using Solid-state Nanopore Sensors
, Journal of Physical Chemistry B, Vol: 118, Pages: 11605-11612, ISSN: 1520-6106Single-stranded DNA (ssDNA) binding protein plays an important role in the DNA replication process in a wide range of organisms. It binds to ssDNA to prevent premature reannealing and to protect it from degradation. Current understanding of SSB/ssDNA interaction points to a complex mechanism, including SSB motion along the DNA strand. We report on the first characterization of this interaction at the single-molecule level using solid-state nanopore sensors, namely without any labeling or surface immobilization. Our results show that the presence of SSB on the ssDNA can control the speed of nanopore translocation, presumably due to strong interactions between SSB and the nanopore surface. This enables nanopore-based detection of ssDNA fragments as short as 37 nt, which is normally very difficult with solid-state nanopore sensors, due to constraints in noise and bandwidth. Notably, this fragment is considerably shorter than the 65 nt binding motif, typically required for SSB binding at high salt concentrations. The nonspecificity of SSB binding to ssDNA further suggests that this approach could be used for fragment sizing of short ssDNA.
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Journal articlePanich S, Wilson KA, Nutall P, et al., 2014,
Label Free Pb(II) Whispering Gallery Mode Sensing Using Self-Assembled Glutathione modified Gold Nanoparticles on an Optical Microcavity
, Analytical Chemistry -
Conference paperNuttall P, Lam E, Albrecht T, 2014,
Label-Free Detection of the P53-DNA Complex Philippa Nuttall
, 58th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 18A-18A, ISSN: 0006-3495 -
Conference paperBahrami A, Lam EW, Albrecht T, 2014,
Probing DNA Methylation in Breast Cancer Cell Lines Using Solid-State Nanopores
, 58th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 18A-18A, ISSN: 0006-3495- Author Web Link
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- Citations: 2
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Journal articleIvanov AP, Freedman KJ, Kim MJ, et al., 2014,
High Precision Fabrication and Positioning of Nanoelectrodes in a Nanopore
, ACS Nano -
Journal articleGibb TR, Ivanov AP, Edel JB, et al., 2014,
Single Molecule Ionic Current Sensing in Segmented Flow Microfluidics
, Analytical Chemistry -
Journal articleInkpen MS, Albrecht T, Long NJ, 2013,
Branched Redox-Active Complexes for the Study of Novel Charge Transport Processes
, ORGANOMETALLICS, Vol: 32, Pages: 6053-6060, ISSN: 0276-7333- Author Web Link
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- Citations: 21
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Journal articleRutkowska A, Edel JB, Albrecht T, 2013,
Mapping the Ion Current Distribution in Nanopore/Electrode Devices
, ACS Nano -
Journal articleInkpen MS, Du S, Driver M, et al., 2013,
Oxidative purification of halogenated ferrocenes
, Dalton Transactions, Vol: 42, Pages: 2813-2816 -
Journal articleJaprung D, Dogan J, Freedman KJ, et al., 2013,
Single Molecule Studies of Intrinsically Disordered Proteins Using Solid-State Nanopores
, Analytical Chemistry -
Journal articleInkpen MS, White AJP, Albrecht T, et al., 2013,
Rapid Sonogashira cross-coupling of iodoferrocenes and the unexpected cyclo-oligomerization of 4-ethynylphenylthioacetate
, Chem. Commun. -
Journal articleCecchini MP, Wiener A, Turek V, et al., 2013,
Rapid Ultra-Sensitive Single Particle Surface Enhanced Raman Spectroscopy using Metallic Nanopores
, Nano Letters -
Journal articleCarminati M, Ferrari G, Ivanov AP, et al., 2013,
Design and characterization of a current sensing platform for silicon-based nanopores with integrated tunneling nanoelectrodes
, Analog Integrated Circuits and Signal Processing, Pages: 1-11 -
Journal articleBahrami A, Dogan F, Japrung D, et al., 2012,
Solid-state nanopores for biosensing withsubmolecular resolution
, Biochemical Society Transactions, Vol: 40, Pages: 624-628Biological cell membranes contain various types of ion channels and transmembrane pores in the 1–100 nm range, which are vital for cellular action. Individual channels can be probed electrically, as demonstrated by Neher and Sakmann in 1976 using the patch-clamp technique [Neher and Sakmann (1976) Nature 260, 799–802]. Since the 1990s, this work has inspired the use of protein or solid-state nanopores as inexpensive and ultrafast sensors for the detection of biomolecules, including DNA, RNA and proteins, but with particular focus on DNA sequencing. Solid-state nanopores in particular have the advantage that the pore size can be tailored to the analyte in question and that they can be modified using semi-conductorprocessing technology. This establishes solid-state nanopores as a new class of single-molecule biosensor devices, in some cases with submolecular resolution. In the present review, we discuss a few of the most important recent developments in this field and how they might be applied to studying protein–protein and protein–DNA interactions or in the context of ultra-fast DNA sequencing.
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Journal articleAlbrecht T, 2012,
Electrochemical Tunnelling Sensors and Their Potential Applications
, Nature Communications -
Journal articleChansin GAT, Hong J, Dusting J, et al., 2011,
Resizing Metal-Coated Nanopores Using a Scanning Electron Microscope
, SMALL, Vol: 7, Pages: 2736-2741, ISSN: 1613-6810- Author Web Link
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- Citations: 5
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Journal articleAlbrecht T, 2011,
How to Understand and Interpret Current Flow in Nanopore/Electrode Devices
, ACS NANO, Vol: 5, Pages: 6714-6725, ISSN: 1936-0851 -
Journal articleAlbrecht T, 2011,
NANOBIOTECHNOLOGY A new look for nanopore sensing
, NATURE NANOTECHNOLOGY, Vol: 6, Pages: 195-196, ISSN: 1748-3387- Author Web Link
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- Citations: 16
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Journal articleCecchini MP, Hong J, Lim C, et al., 2011,
Ultra-Fast Surface Enhanced Resonance Raman Scattering (SERRS) Detection in Droplet-Based Microfluidic Systems
, Analytical Chemistry -
Journal articleCecchini MP, Stapountzi MA, McComb DW, et al., 2011,
Flow-Based Autocorrelation Studies for the Detection and Investigation of Single-Particle Surface-Enhanced Resonance Raman Spectroscopic Events
, Analytical Chemistry -
Journal articleInkpen MS, Albrecht T, 2011,
Probing Electron Transport in Proteins at Room Temperature with Single-Molecule Precision
, ACS nano, Vol: 6, Pages: 13-16 -
Journal articleIvanov AP, Instuli E, McGilvery C, et al., 2010,
DNA tunneling detector embedded in a nanopore
, Nano Letters, Vol: 11, Pages: 279-285, ISSN: 1530-6992We report on the fabrication and characterization of a DNA nanopore detector with integrated tunneling electrodes. Functional tunneling devices were identified by tunneling spectroscopy in different solvents and then used in proof-of-principle experiments demonstrating, for the first time, concurrent tunneling detection and ionic current detection of DNA molecules in a nanopore platform. This is an important step toward ultrafast DNA sequencing by tunneling.
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Journal articlePerkin S, Albrecht T, Klein J, 2010,
Layering and shear properties of an ionic liquid, 1-ethyl-3-methylimidazolium ethylsulfate, confined to nano-films between mica surfaces
, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 12, Pages: 1243-1247, ISSN: 1463-9076- Author Web Link
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- Citations: 250
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Journal articleAyub M, Hong J, Albrecht T, et al., 2010,
Fabrication of Metallised Solid-State Nanopores Using Electrodeposition with Ionic Current Feedback
, BIOPHYSICAL JOURNAL, Vol: 98, Pages: 598A-598A, ISSN: 0006-3495 -
Journal articleAlbrecht T, Edel JB, Winterhalter M, 2010,
New developments in nanopore research—from fundamentals to applications (Preface)
, Journal of Physics: Condensed Matter, Vol: 22 -
Journal articleAyub M, Ivanov A, Instuli E, et al., 2010,
Nanopore/electrode structures for single-molecule biosensing
, Electrochimica Acta, Vol: 55, Pages: 8237-8243 -
Journal articleIvanov A, Instuli E, Hong J, et al., 2010,
Novel Nanoscale Tunneling Architectures for DNA Analysis
, Biophysical Journal, Vol: 98, Pages: 422-422 -
Journal articleAyub M, Ivanov A, Hong J, et al., 2010,
Precise electrochemical fabrication of sub-20 nm solid-state nanopores for single-molecule biosensing
, Journal of Physics: Condensed Matter, Vol: 22, Pages: 454128-454128 -
Journal articleZhang J, Kuznetsov AM, Medvedev IG, et al., 2008,
Single-molecule electron transfer in electrochemical environments
, CHEMICAL REVIEWS, Vol: 108, Pages: 2737-2791, ISSN: 0009-2665- Author Web Link
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- Citations: 245
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